CNC implemented the first high-throughput/high-content screening platform in Portugal, equipped with state-of-the-art instrumentation to perform genome-wide loss- and gain-of-function screenings using siRNA/miRNA/CRISPR libraries, as well as screenings using large-scale libraries of chemical compounds. This fully automated platform was specifically designed to promote flexibility and can thus accommodate cell-based screenings using diversified cell models that address a wide range of biological questions.
This unique platform is available to researchers within the CNC ecosystem, as well as to national and international collaborators. The screening platform is integrated into the PT - OPENSCREEN consortium, part of Portuguese Roadmap of Research Infrastructures, as well as the European Research Infrastructure Consortium EU - OPENSCREEEN., and the AccelBio Collaborative Laboratory.
In 2022, the platform was recognized as as a Partner Site (Specialised Screening site) of the European Research Infrastructure Consortium EU - OPENSCREEEN.