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PDBEB 03/04

Gomes-da-Silva, L.C., Santos A.O., Bimbo, L.M., Moura, V., Ramalho, J.S., Pedroso de Lima, M.C., Simoes, S., and Moreira, J.N. (2012). Toward a siRNA-containing nanoparticle targeted to breast cancer cells   and the tumor microenvironment. Int. J. Pharm. 434, 9–19

Santos A.O., Pereira J. P., Pedroso de Lima M. C., Simões S. and Moreira J. N., In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability. Braz J Med Biol Res, 2010. 43(10):1001-1009.

Santos A.O., da Silva L. C., Bimbo L. M., de Lima M. C., Simões S. and Moreira J. N.,  Design of peptide-targeted liposomes containing nucleic acids. Biochim Biophys Acta, 2010. 1798(3):433-41. Epub 2009 Dec 11.

Santos A., Sarmento-Ribeiro A. B., de Lima M. C., Simões S. and Moreira J. N., Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer. Cytometry A, 2008. 73A(12): p. 1165-1172.

Moreira J. N., Santos A., Moura V., Pedroso de Lima, M. C. and Simões S., Non-viral lipid-based nanoparticles for targeted cancer systemic gene silencing. J Nanosci Nanotechnol, 2008. 8(5): p. 2187-204.

Moreira J. N., Santos A. and Simões S., Bcl-2-targeted antisense therapy (Oblimersen Sodium): towards clinical reality. Reviews on Recent Clinical Trials, 2006, 1, 217-235

Santos A., Pereira J. P., Pedroso de Lima M. C., Simões S. and Moreira J. N., SiRNA mediated downregulation of Bcl-2 in small cell lung cancer cell lines - impact on protein level and cell viability. European Journal of Cancer Supplements, 2008. 6(9): p. 74

Santos A., Simões S., Pedroso de Lima M. C. and Moreira J. N., Novel targeted non-viral lipid-based vector for the treatment of human Small Cell Lung Cancer: Intracellular delivery of antisense oligonucleotides. Revista Portuguesa de Farmácia, 2005. LII (nº2) supplement: p. 125, 126.

Capítulos de livros:
Moreira J. N., Santos A., Bimbo L. M., Gomes da Silva L. C., Pedroso de Lima M. C., Simões S., Gene silencing therapy in small cell lung cancer – which agents, targets, and delivery systems? , Jonathon G. Maldonado and Mikayla K. Cervantes (ed.), Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, Chapter 1, p. 1-51, (2009).  ISBN: 978-1-60741-787-3

Grskovic M, Chaivorapol C, Gaspar-Maia A, Li H, Ramalho-Santos M. (2007) Systematic identification of cis regulatory sequences active in mouse and human embryonic stem cells. PLoS Genetics 3(8): e145
 
Teles-Grilo ML, Duarte SM, Tato-Costa J, Gaspar-Maia A, Oliveira C, Rocha AA, Marques A, Cordeiro-da-Silva A, Azevedo C. (2007) Molecular karyotype analysis of Perkinsus atlanticus (Phylum Perkinsozoa) by pulsed field gel electrophoresis. Eur J Protistol. 43(4):315-8.
 
Teles-Grilo ML, Tato-Costa J, Duarte SM, Gaspar-Maia A, Casal G, Azevedo C. (2007) Is there a plastid in Perkinsus atlanticus (Phylum Perkinsozoa)? Eur J Protistol. 43(2):163-7.
 
Heidersbach A, Gaspar-Maia A, McManus M, Ramalho-Santos M. (2006) RNA interference in embryonic stem cells and the prospects for future therapies. Gene Therapy 13:478-86
 
Grandela C and Wolvetang E (2007) hESC Adaptation, Selection and Stability. Stem Cell Reviews. 2007. 3, 183-91.
 
Grandela C, Pera MF and Wolvetang EJ. p53 is required for etoposide-induced apoptosis of human embryonic stem cells. Stem Cell Res. 2007 Nov;1(2):116-28. doi: 10.1016/j.scr.2007.10.003. Epub 2007 Oct 22.
 
Dobbelaere J, Josué F, Suijkerbuijk S, Baum B, Tapon N and Raff J. (2008)
A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila PLoS Biol 6(9): e224 doi:10.1371/journal.pbio.0060224

Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Curr Biol. 2006 Jul 25;16(14):1453-8.
http://dx.doi.org/10.1016/j.cub.2006.05.059
 
Sequeira-Mendes J, Díaz-Uriarte R, Apedaile A, Huntley D, Brockdorff N, and Gomez M (2009). Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells. PLoS Genet 5(4): e1000446. doi:10.1371/journal.pgen.1000446 

Ferreira M, Fujiwara H, Morita K, Watt FM. An activating beta 1 integrin mutation increases conversion of benign to malignant skin tumours. Cancer Res 2009; 69(4): 1335-1342 .
 
Young ARJ, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JFJ, Tavaré S, Arakawa S, Shimizu S, Watt FM and Narita M. Genes Dev. 2009 Mar 11. [Epub ahead of print].
 
Santos SD, Iuliano O, Ribeiro L, Veran J, Ferreira JS, Rio P, Mulle C, Duarte CB and Carvalho AL. Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. J Biol Chem. 2012 Feb 24;287(9):6868-77. doi: 10.1074/jbc.M111.322909. Epub 2012 Jan 5.

Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J. (2010) Leptin regulates AMPA receptor trafficking via PTEN inhibition J Neurosci. 30(11):4088-101.

Santos SD, Manadas B, Duarte CB and Carvalho AL. (2010) Proteomic analysis of an interactome for long-form AMPA receptor subunits. J Proteome Res. 9(4):1670-82

Santos SD, Carvalho AL, Caldeira MV, and Duarte CB. (2009). Regulation of AMPA receptors and synaptic plasticity. Neuroscience. 12;158(1):105-25
 
Carvalho AL, Caldeira MV, Santos SD and Duarte CB. (2008) Role of the brain-derivedneurotrophic factor at glutamatergic synapses Br J Pharmacol. 153 Suppl 1:S310-24.
 
Moreno AJ, Oliveira PJ, Nova CD, Alvaro AR, Moreira RA, Santos SM, Macedo, T. Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization. J Biochem Mol Toxicol. 2007;21(2):53-61.
 
Malva JO, Santos S, & Macedo TR. (2004) Neuroprotective properties of Valeriana officinalis extracts. Neurotoxicity Research 6(2):131-40
 
Pereira CF, Santos SD, Ribeiro CF, Ali SF, and Macedo TR. (2004) A single exposure to morphine induces long-lasting hyporreactivity of rat caudate putamen dopaminergic nerve terminals. Ann. N.Y. Acad. Sci 1025:414-23
 
Nobrega-Pereira S and Marín O. Transcriptional control of neuronal migration in the developing mouse brain. Cereb Cortex. 2009 Jul;19 Suppl 1:i107-13. doi: 10.1093/cercor/bhp044. Epub 2009 Apr 8. IF 6.979

Nobrega-Pereira S, Kessaris N, Du T, Kimura S, Anderson S, Marín O. Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors.
Neuron. 2008 Sep 11:59(5):733-45.
 
Lavreysen H, Wouters R, Bischoff F, Nobrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L and Lesage ASJ. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004 Dec: 47(7): 961-72.
 
Lavreysen H, Nobrega Pereira S, Leysen JE, Langlois X, Lesage ASJ. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr: 46(5): 609-19.

Maia-Lopes S1, Silva ED, Reis A, Silva MF, Mateus C, Castelo-Branco M.
Retinal Function in Best Macular Dystrophy: Relationship Between Electrophysiological, Psychophysical and Structural Measures of Damage. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5553-60. doi: 10.1167/iovs.08-2093. Epub 2008 Sep 4. PMID: 18775865 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Aguirre J, Riveiro-Alvarez R, Trujillo-Tiebas MJ, Ayuso C. Gene symbol: BEST1. Disease: Best macular dystrophy.Hum Genet. 2008 Feb;123(1):112. PMID: 18386373 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Aguirre-Lamban J, Riveiro-Alvarez R, Trujillo-Tiebas MJ, Ayuso C. Gene symbol: ABCA4. Disease: Stargardt disease. Hum Genet. 2008 Jun;123(5):555. PMID: 20960665 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Aguirre J, Riveiro-Alvarez R, Trujillo-Tiebas MJ, Ayuso C. Gene symbol: ABCA4. Disease: Macular dystrophy. Hum Genet. 2008 Feb;123(1):112. PMID: 18386369 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Aguirre J, Riveiro-Alvarez R, Trujillo-Tiebas MJ, Ayuso C.Gene symbol: ABCA4. Disease: Macular dystrophy. Hum Genet. 2008 Feb;123(1):111. PMID: 18386365 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Villaverde C, Aguirre J, Trujillo-Tiebas MJ, Ayuso C.
Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):111. PMID:18386360 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Villaverde C, Aguirre J, Trujillo-Tiebas MJ, Ayuso C.
Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):110-1. PMID:18386356 [PubMed - indexed for MEDLINE]

Maia-Lopes S1, Castelo-Branco M, Silva E, Villaverde C, Aguirre J, Trujillo-Tiebas MJ, Ayuso C.
Gene symbol: BEST1. Disease: Best macular dystrophy. Hum Genet. 2008 Feb;123(1):110. PMID:18386350 [PubMed - indexed for MEDLINE]

Maia-Lopes S, Silva ED, Silva MF, Reis A, Faria P, Castelo-Branco M. Evidence of widespread retinal dysfunction in patients with stargardt disease and morphologically unaffected carrier relatives. Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1191-9. doi: 10.1167/iovs.07-1051. PMID:18326749 [PubMed - indexed for MEDLINE]

Silva MF, Maia-Lopes S, Mateus C, Guerreiro M, Sampaio J, Faria P, Castelo-Branco M.
Retinal and cortical patterns of spatial anisotropy in contrast sensitivity tasks. Vision Res. 2008 Jan;48(1):127-35. Epub 2007 Dec 11.
PMID:18067943 [PubMed - indexed for MEDLINE]

Maia-Lopes S, Aguirre-Lamban J, Castelo-Branco M, Riveiro-Alvarez R, Ayuso C, Silva ED.
ABCA4 mutations in Portuguese Stargardt patients: identification of new mutations and their phenotypic analysis. Mol Vis. 2009;15:584-91. Epub 2009 Mar 25.
PMID:19365591 [PubMed - indexed for MEDLINE]

Vital AL, Tabernero MD, Castrillo A, Rebelo O, Tão H, Gomes F, Nieto AB, Resende Oliveira C, Lopes MC, Orfao A. (2010) Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology. Neuro Oncol. 12(9):991-1003.

Vital AL, Tabernero MD, Crespo I, Rebelo O, Tão H, Gomes F, Lopes MC, Orfao A. (2010) Intratumoral patterns of clonal evolution in gliomas. Neurogenetics,11(2): 227-39.

Crespo I, Vital AL, Nieto AB, Rebelo O, Tão H, Lopes MC, Oliveira CR, Orfao A, Tabernero MD. (2011) Detailed characterization of alterations of chromosomes 7, 9 and 10 in glioblastomas as assessed by single nucleotide polymorphism arrays. Journal of Molecular Diagnostics, 13(6):634-47.

 
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