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PDBEB 02/03

Santiago AR
, Garrido MJ, Cristóvão AJ, Duarte JM, Carvalho RA, Ambrósio AF. (2010) Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy. Curr Eye Res.  35(11):992-1001.

Pereira Tde O, da Costa GN, Santiago AR, Ambrósio AF, dos Santos PF. (2010) High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia. Brain Res.1316:129-38. Epub 2009 Dec 23.

Santiago AR, Gaspar JM, Baptista FI, Cristóvão AJ, Santos PF, Kamphuis W, Ambrósio AF. (2009) Diabetes changes the levels of ionotropic glutamate receptors in the rat
retina. Mol Vis. 15:1620-30.
 
Santiago AR, Carvalho CM, Carvalho AP, Ambrósio AF (2008). Differential  Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca2+]i Changes  Evoked by Kainate in Hippocampal Neurons. Neurochem Res; 33(8):1501-1508. 
 
Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO, Ambrósio AF (2008). Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res; 1198:153-159. 
 
Santiago AR, Santos PF, Cristóvão AJ, Carvalho CM, Ambrósio AF (2007).High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis; 25(3): 464-472.
 
Alvaro AR, Rosmaninho-Salgado J, Santiago AR, Martins J, Aveleira C, Santos PF, Pereira T, Gouveia D, Carvalho AL, Grouzmann E, Ambrósio AF, Cavadas C (2007). NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Muller cells. Neurochem Int; 50(5): 757-763.
 
Santiago AR, Rosa SC, Santos PF, Cristóvão AJ, Barber AJ, Ambrósio AF (2006). High glucose decreases Ca2+ permeability of AMPA receptors and alters calcium homeostasis in retinal neural cells. Invest Ophthalmol Vis Sci; 47(9): 4130-4137.
 
Santiago AR, Pereira TS, Garrido MJ, Cristóvão AJ, Santos PF, Ambrósio AF (2006). High glucose and diabetes increase the release of [3H]-D-aspartate in retinal cell cultures and in rat retinas. Neurochem Int; 48(6-7): 453-458.
 
EC Leal, Santiago AR, Ambrósio AF (2005). The old and new drug targets in Diabetic Retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord; 4(4):421-434
 
Bras-Pereira C, Casares F. (2008) An antennal-specific role of bowl in repressing wingless to ensure correct proximo-distal axis specification. Mech Dev. 125(9-10): 809-21.

Tena JJ, Neto A, de la Calle-Mustienes E, Bras-Pereira C, Casares F*,Gomez-Skarmeta JL*. (2007) Odd-skipped genes encode repressors that control kidney development. Dev Biol. 301(2):518-31.

Bras-Pereira C
, Bessa J, Casares F. (2006) Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila. Development 133(21): 4145-9.
 
Fleming CE, Saraiva MJ, Sousa MM. (2007) Transthyretin enhances nerve regeneration.  J Neurochem 103:831-9.

Fleming CE, Nunes AF, Sousa MM. (2009) Transthyretin: more than meets the eye.
Prog Neurobiol 89(3):266-76.

Mar FM, Franquinho F, Fleming CE, Sousa MM. (2009) Transthyretin in peripheral nerve regeneration. Int Rev Neurobiology 87:337-46

Fleming CE, Mar FM, Franquinho F, Sousa MM. (2009) Transthyretin: an enhancer of nerve regeneration. Int Rev Neurobiol, 87:337-46.

Fleming CE, Mar FM, Franquinho F, Saraiva MJ, Sousa MM. (2009) Transthyretin internalization by neurons is megalin-mediated and necessary for its neuritogenic activity. J Neurosci 29:3220-32.

Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik SC, Powers JC, Bogyo M and Sousa MM. (2009) Substrate specificity of transthyretin: identification of natural substrates in the nervous system. Biochem J 419:467-74.

Schlahsa L, Jaimes Y, Blasczyk R, Figueiredo C. (2010) Granulocyte-colony-stimulatory factor: a strong inhibitor of natural killer cell function. Transfusion [Epub ahead of print]

Jaimes Y, Figueiredo C, Blasczyk R. (2010) RNAi-mediated silencing of PECAM-1 expression prevents T cell-mediated cytotoxicity. Transfusion. [Epub ahead of print]

Figueiredo C, Goudeva L, Eiz-Vesper B, Horn PA, Blasczyk R, Seltsam A. (2010) Generation of HLA-deficient platelets from hematopoietic progenitor cells. Transfusion 50(8):1690-701.

Figueiredo C, Wittmann M, Dressel R, Seltsam A, Blasczyk R, Eiz-Vesper B. (2009) Heat Shock Protein 70 (HSP70) induces cytotoxicity of T helper cells. Blood 26;113(13):3008-16

Figueiredo C, Seltsam A, Blasczyk R. (2009) Permanent silencing of NKG2A expression for cell-based therapeutics. J Mol Med 87(2):199-210

Seltsam A, Grüger D, Just B, Figueiredo C, Gupta CD, Deluca DS, Blasczyk R. (2008) Aberrant intracellular trafficking of a variant B glycosyltransferase. Transfusion.

Horn PA, Figueiredo C, Kiem HP. (2007) Gene therapy in the transplantation of allogeneic organs and stem cells. Curr Gene Ther  7:458-68

Figueiredo C, Horn PA, Blasczyk R, Seltsam A. (2007) Regulating MHC expression for cellular therapeutics. Transfusion 47: 18-27

Figueiredo C, Seltsam A, Blasczyk R. (2006) Class-, gene- and group-specific HLA silencing by lentiviral shRNA delivery. J Mol Med 84: 425-37

Bade-Doeding C, Eiz-Vesper B, Figueiredo C, Seltsam A, Elsner HA, Blasczyk R. (2005) Peptide-binding Motif of HLA-A*6603. Immunogenetics  56: 769-72

Leal EC
, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, Forrester JV, Ambrósio AF. (2009) High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway. Exp Eye Res.88(5):983-91.

Leal EC
, Aveleira CA, Castilho AF, Baptista FI, Ambrósio AF. (2008) Müller cells do not influence leukocyte adhesion to retinal endothelial cells. Ocul Immunol Inflamm. 16 (4):173-9.
 
Leal EC, Manivannan A, Hosoya K, Terasaki T, Cunha-Vaz J, Ambrósio AF, Forrester JV. (2007) Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 48(11):5257-65.
 
Leal EC, Santiago AR, Ambrósio AF. (2005) Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord.  4(4):421-34. Review.
 
Pereira GA, Ball L, SherryAD, Peters JA, Geraldes CFGC. (2009)NMR Characterization of Ln3+ Complexes of Tetraazaphosphinate and Phosphonate Ligands. Helvetica Chimica Acta. 92, 2532-2552.
 
Kotková Z, Pereira GA, Djanashvili K, Kotek J, Rudovský J, Hermann P, Elst LV, Muller RN, Geraldes CFGC, Luke I, Peters JA. (2009) Lanthanide(III) Complexes of Phosphorus Acid Analogues of H4DOTA as Model Compounds for the Evaluation of the Second-Sphere Hydration. Eur. J. Inorg. Chem. 9(1), 119-136.

Pereira GA, Ananias D, Rocha J, Amaral VS, Muller RN, Elst LV, Tóth É, Peters JA, Geraldes CFGC. (2005) NMR relaxivity of Ln3+-based zeolite-type materials. J. Mater. Chem.15, 3832-3837
 
Pereira GA, Norek M, Peters JA, Ananias D, Rocha J, Geraldes CFGC. (2008) NMR Transversal Relaxivity of Aqueous Suspensions of Particles of Ln3+-Based Zeolite Type Materials. Dalton Transactions. 2241-2247

Pereira GA, Geraldes CFGC. (2007) Design and Optimization of Gadolinium Based Contrast Agents for Magnetic Resonance Imaging. Ann. Magn. Reson. 6 (1,2), 1-33
 
Torres S, Martins JA, André,JP, Pereira GA, Kiraly R, Brücher E, Helm L, Tóth E, Geraldes CFGC. (2007) H5EPTPACH2OH: Synthesis, relaxometric characterization and 1H NMR studies of the solution dynamics of its Ln(III) complexes. Eur.J.Inorg.Chem. 35, 5489-5499

Norek M, Pereira GA, Geraldes CFGC, Denkova A, Zhou W, Peters JA. (2007) NMR Transversal relaxivity of suspensions of lanthanide oxide nanoparticles. J. Phys. Chem. C. 111, 10240-10246

Campelo MP, Lacerda S, Santos IC, Pereira GA, Geraldes CFGC, Kotek J, Hermann P, Vanek J, Lubal P, Kubícek V, Tóth É, Santos I. (2010) Lanthanide(III) Complexes of 4,10-Bis (phosphonomethyl)-1,4,7,10 tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in Solution and in the Solid State: Structural Studies Along the Series”, Chem. Eur. J.  16, 8446-8465.

Pereira GA, Peters JA, Paz FAA, Rocha J, Geraldes CFGC. (2010) Evaluation of [Ln(H2cmp)(H2O)] Metal Organic Framework Materials for Potential MRI Contrast Agents. Inorganic Chemistry. 49, 2969-2974

Pinho S. L, Pereira GA, Voisin P, Kassem J, Bouchaud V, Etienne L, Peters JA, Carlos L, Mornet S, Geraldes CFGC, Rocha J, Delville M-H, (2010) Fine Tuning of the Relaxometry of g-Fe2O3@SiO2 Nanoparticles by Tweaking the Silica Coating Thickness. ACS Nano 4(9), 5339-5349.

Empadinhas N, Pereira PJ, Albuquerque L, Costa J, Sá-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS. (2011) Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity. Molecular Microbiology. 79(1):76-93.

Costa J, Tiago I, da Costa MS, Veríssimo A. (2010) Molecular evolution of Legionella pneumophila dotA gene, the contribution of natural environmental strains. Environmental Microbiology. 12(10), 2711–2729.
 
Costa J, da Costa MS, Veríssimo A. (2010) Colonization of a therapeutic spa with Legionella spp: a public health issue. Research in Microbiology. 161(1):18-25.
 
Fernandes C, Mendes V, Empadinhas N, Costa J, Lamosa P, Borges N, Santos H, da Costa MS. (2010) Two alternative pathways for the synthesis of the rare compatible solute mannosyl-a-1,2-glucosylglycerate in Petrotoga mobilis. Journal of Bacteriology 192(6):1624-33.
 
Costa J, Empadinhas N, and da Costa MS. (2007) Glucosylglycerate biosynthesis in the deepest lineage of Bacteria:Characterization of the thermophilic GpgS and GpgP from Persephonella marina. Journal of Bacteriology. 189:1648-1654.
 
Costa J, Empadinhas N, Gonçalves L, Lamosa P, Santos H, da Costa MS. (2006) Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. Journal of Bacteriology. 183:1022-1030.
 
Costa J, Tiago I, da Costa MS, Veríssimo A. (2005) The presence and persistence of Legionella spp. in groundwaters. Applied and Environmental Microbiology. 71:663-671.
 
Costa J, Empadinhas N, and da Costa MS. Elucidation of the biosynthetic pathway of glucosylglycerate. Characterization of key-enzymes. Febs Journal.
 
Empadinhas N, Albuquerque L, Costa J, da Costa MS. (2005) A highly divergent MpgS accounts for the synthesis of mannosylglycerate in the gram-positive bacterium Rubrobacter xylanophilus
Febs Journal.
 
Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos M, Santos H, da Costa MS. (2004) A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase. Journal of Bacteriology. 186:4075-4084.
 
Santos P, Pinhal I, Rainey F, Empadinhas N, Costa J, Fields B, Benson R, Veríssimo A. da Costa MS. (2003) Gamma-Proteobacteria Aquicella lusitana gen. nov., sp. nov., and Aquicella siphonis sp. nov. Infect Protozoa and Require Activated Charcoal for Growth in Laboratory Media. Applied and Environmental Microbiology. 69:6533-6540.

Miguel Castelo-Branco, Mafalda Mendes, Fátima Silva, João Massano, Gustavo Januário, Cristina Januário, António Freire. (2008) “Motion integration deficits are independent of magnocellular impairment in Parkinson´s disease”

Castelo-Branco, M., Mendes M., Sebastião, A.R., Reis, A., Soares, M., Saraiva J., Bernardes, R., Flores, R., Pérez-Jurado, L., Silva, E. (2007) “A novel visual phenotype in Williams syndrome challenges magnocellular theories explaining neurodevelopmental visual cortical disorders” Journal of Clinical Investigation 117(12):3720-9. (Mafalda Mendes e Miguel Castelo-branco partilham a 1ª autoria)
 
Castelo-Branco M, Mendes M, Silva MF, Januário C, Machado E, Pinto A, Figueiredo P, Freire A. (2006) “Specific retinotopically based magnocellular impairment in a patient with medial visual dorsal stream damage” Neuropsychologia 44 (2):238-53.
 
Mendes M., Silva F., Simões L., Jorge M., Saraiva J., and Castelo-Branco M. (2005) "Visual magnocellular and structure from motion perceptual deficits in a neurodevelopmental model of dorsal stream function” Cognitive Brain Research 25(3):788-98.
 
Caldeira MV, Curcio M, Leal G, Santos AR , Melo CV, Pereira P, Canzoniero L and Duarte CB. (2011) Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons. Cell Death and Differentiation (submitted).

Baptista MS, Melo CV, Armelão M, Herrmann D, Pimentel DO, Leal G, Caldeira MV, Bahr BA, Bengtson M, Almeida RD, Duarte CB (2010) Role of the Proteasome in Excitotoxicity-Induced-Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons. PLos ONE, 5: e10139.

Santos SD, Carvalho AL, Caldeira MV and Duarte CB (2009) Regulation of AMPA receptors and synaptic plasticity. Neuroscience 158: 105-125.

Carvalho AL, Caldeira MV, Gomes AR, Carvalho AP and Duarte CB. (2008) Regulation of AMPA receptors by metabotropic receptors and receptor tyrosine kinases: mechanisms and physiological roles. In Handbook of Neurochemistry & Molecular Neurobiology, volume 2 (Neurotransmitter Systems; M. Hamon and E.S.Vizi eds.), 3rd edition, Kluwer.

Carvalho AL, Caldeira MV, Santos SD and Duarte CB. (2008) Role of BDNF at glutamatergic synapses. Br J Pharmacol 153:Suppl 1:S310-S324.

Caldeira MV, Melo CV, Pereira DB, Carvalho AL and Duarte CB. (2007) BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Molecular & Cellular Neuroscience 35: 208-219

Caldeira MV, Melo CV, Pereira DB, Carvalho R, Correia S, Backos DS, Carvalho AL, Esteban JA and Duarte CB. (2007) BDNF regulates the expression and the synaptic delivery of AMPA receptor subunits in hippocampal neurons. Journal of Biological Chemistry 282:12619-12628

Oliveira, R.A., Coelho, P.A. and Sunkel, C.E. (2005). The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. Mol Cell Biol, 25, 8971-8984.
 
Oliveira, R.A, Heidmann, S., and Sunkel, C.E. (2007). Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes. Chromosoma (published online on 27th February 2007).

Tadeu AMB, Ribeiro S, Johnston J, Goldberg I, Gerloff D, and Earnshaw WC. (2008) CENP-V is required for centromere organization, chromosome alignment and cytokinesis. EMBO J. 27, 2510–2522.

 
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