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Advanced Therapies
 
May 7 - 11
Coordinator: Luís P Almeida - luispa@cnc.uc.pt
PhD in Experimental Biology and Biomedicine
CNC - Center for Neuroscience and Cell Biology, University of Coimbra

Advanced Therapies 2018
May 7-11, 2018



Coordinators:
Luís Pereira de Almeida (luispa@cnc.uc.pt)
Lino da Silva Ferreira (Lino@biocant.pt)

Lecturers:

Lino Ferreira
Ricardo Neves
Hugo Fernandes
Mário Grãos
Irina Moreira
Miguel Mano
Susana Simões,
Vitor Francisco
Catarina Rebelo
Sonia Pinho
Miguel Lino
Patrícia Pitrez
Luís Estronca
Catarina Almeida
Akhilesh Rai
Tiago Rondão
Arnab Banerjee
Ana Cardoso
Olga Borges
Luis Pereira de Almeida
Ana Teresa Simões
Ana Rita Álvaro
Carlos Matos
Catarina Miranda
Liliana Mendonça
Magda Santana
Patrícia Albuquerque
Rita Perfeito
Rui Nobre
Sara Lopes
Sónia Duarte



COURSE SYLLABUS

May 7th Monday in Coimbra
9.30h-9:45h: Course Presentation
Luís Pereira de Almeida

9:45-10:30: Molecular therapy of brain disorders
Luís Pereira de Almeida

10:45- 11:30: Transplantation of Neural Stem Cells as a therapeutic strategy
Liliana Mendonça

11:30- 12:15: Mesenchymal stem cells in brain disorders
Catarina Miranda


14.30h-15:00h: Induced pluripotent stem cells to model neurodegeneration
Ana Rita Álvaro

16:00-16:30: Stem cells and exosomes: a bi-directional intercommunication
Rita Perfeito


May 8th Tuesday in Coimbra
9:30-10:15– Viral Vectors: from Production to Opportunities
Rui Nobre

10:30- 11:45h: Gene editing strategies in gene therapy
Sara Lopes and Carlos Matos

11:45-12:30: MicroRNA-mediated gene silencing in neurodegenerative disease
Sónia Duarte

12.30h-13.00h: LncRNAs as potential targets for cancer therapy
Ana Maria Cardoso

Lunch

14:30h-15:00 Exosomes as biomarkers and gene carriers to the brain
Patrícia Albuquerque

15:00- 15:30h: Inhibition of calpain-mediated proteolysis of mutant ataxin-3 as a therapeutic strategy in Machado-Joseph Disease
Ana Teresa Simões

15:30- 16:00h: Biomarkers
Magda Santana

16:15 – 17:00 Playing around with Vaccines
Olga Borges


May 9th in Cantanhede
9.00h-10.30h: Regenerative Medicine: from the bench to the bedside + stem cells and drug screening
Hugo Fernandes

11:00- 12:30h- Metabolic modulation can impact on stem cell physiology
Ricardo Neves

14.00h-15.30h- Biomaterials to modulate the activity of stem cells
Lino Ferreira

16:00h- 17:30h- Stem cells and mechanotransduction
Mário Grãos


May 10th in Cantanhede

9.00h-10.30h: “Exploring functional genomics for the development of RNA-based therapeutics”
Miguel Mano

Coffee break

11.00h-12.30h: “To be announced”
Irina Moreira

Lunch

14.00h-14.20h: High-throughput and high content screening
Susana Simões

14:20h-14:40h: Highlights of running projects I
Miguel Lino

14.40h-15.00h: Highlights of running projects II
Catarina Rebelo/Sonia Pinho

15:00- 15:20h: Highlights of running projects III
Vitor Francisco

15:20- 16:00h:  Coffee break

16:00- 16:20h: Highlights of running projects IV
Patricia Pitrez

16:20- 16:40h: Highlights of running projects V
Catarina Almeida

16:40-17:00h: Highlights of running projects VII
Akhilesh Rai

17:00- 17:20h: Highlights of running projects VI
Tiago Rondão/Arnab Banerjee


May 11th in Coimbra

9:00 – 12:30 Assignements - Presentation of papers


14:00 Seminar: Building the preclinical package towards clinical investigation of human neural stem cells in age related macular degeneration.
Alexandra Capela
Biotechnology Consultant; Former Senior Director of Research - StemCells inc, Palo Alto, USA.



Background Reading:


Palsson, B.Ø. and Bhatia, S.N., Tissue Engineering, Pearson Prentice Hall Bioengineering, 2004;
Vunjak-Novakovic, G. and Freshney, R., Culture of Cells for Tissue Engineering, Wiley, 2006;

Atala, A., Lanza, R., et al, Principles of Regenerative Medicine, Academic Press, 2007;

Schaffer, D., Bronzino J.D., Peterson, D.R., Stem Cell Engineering, Principles and Practices, CRC Press, 2013;

Xu, J, Du, Y., Deng, H. Direct Lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell 2015, 16, 119

Joana Saraiva, Rui Nobre and Luis Pereira de Almeida. Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9. Journal of Controlled Release. 2016 Nov 10;241:94-109. doi: 10.1016/j.jconrel.2016.09.011. IF 7.786.

Rufino-Ramos D, Albuquerque PR, Carmona V, Perfeito R, Nobre RJ, Pereira de Almeida L.Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases. J Control Release. 2017 Sep 28;262:247-258. doi: 10.1016/j.jconrel.2017.07.001. Epub 2017 Jul 4. Review.

Mendonça LS, Onofre I, Miranda CO, Perfeito R, Nóbrega C, de Almeida LP. Stem Cell-Based Therapies for Polyglutamine Diseases. Adv Exp Med Biol. 2018;1049:439-466. doi: 10.1007/978-3-319-71779-1_21.

Matos CA, Carmona V, Vijayakumar UG, Lopes S, Albuquerque P, Conceição M, Nobre RJ, Nóbrega C, de Almeida LP. Gene Therapies for Polyglutamine Diseases. Adv Exp Med Biol. 2018;1049:395-438. doi: 10.1007/978-3-319-71779-1_20.

Nóbrega C, Simões AT, Duarte-Neves J, Duarte S, Vasconcelos-Ferreira A, Cunha-Santos J, Pereira D, Santana M, Cavadas C, de Almeida LP.Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis. Adv Exp Med Biol. 2018;1049:349-367. doi: 10.1007/978-3-319-71779-1_18.


Global Assessment of Stem Cell Engineering
(http://scec.gatech.edu/sites/default/files/StemCellEngineering-CompleteReport.pdf).

Regenerative Medicine 2006
(can be downloaded at http://stemcells.nih.gov/info/scireport/2006report.htm).

StemBook, http://www.stembook.org/, Harvard Stem Cell Institute
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