PDBEB course “Neurodegenerative disorders”
CNC Auditorium
April 23-27, 2018
Organizers:
Ana Cristina Rego and Cláudia MF Pereira
Objectives:
This course will focus on the latest research in the field of neurodegenerative diseases, by converging on the study of basic mechanisms of neurodegeneration that occur in Alzheimer s disease (AD), Parkinson s disease (PD), and polyglutamine expansion diseases (Ataxias and Huntington s disease). Moreover, clinical and neuropathological aspects, as well as therapeutic strategies of these disorders will be addressed.
Daily Programme:
Monday (April 23) Mechanisms of neuronal dysfunction and Seminar 1
09:00-09:30 Presentation of students and speakers. Presentation of student s assignments.
Ana Cristina Rego and Cláudia MF Pereira
09:30-10:00 Proteostasis pathways
Cláudia MF Pereira
10:00-10:45 Neuroinflammation and synaptotoxicity: a focus on astrocytes
Paula Agostinho
10:45-11:00 Break
11:00-11:45 Neuronal mitochondrial (dys)function
Jorge Oliveira
11:45-12:30 Nitric oxide-mediated signaling in neurological diseases
João Laranjinha
12:30-14:00 Lunch
14:00-15:00 Seminar 1: Targeting the kynurenine pathway in neurodegenerative diseases
Flaviano Giorgini
15:00-15:30 Break
15:30-16:15 Dysregulation of GABAergic synapses and excitototoxic neuronal death
Carlos B. Duarte
16:15-17:00 Use of fly models to study neurodegenerative diseases
Flaviano Giorgini
17:00-17:30 Meet the expert with Flaviano Giorgini
Tuesday (April 24) Alzheimer s disease (AD)
09:30-10:15 Dementia: clinical aspects and clinical trials
Isabel Santana
10:15- 11:00 “Machine learning” for AD diagnosis
Hugo Alexandre Ferreira
11:00-11:15- Break
11:15-12:00 The genetic component of AD
Rosário Almeida
12:00-12:30 Neurogenesis in AD
Elisabete Ferreiro
12:30-14:00 Lunch
14:00-14:45 Metabolic dysfunction in AD
Paula Moreira
14:45-15:30 Redox regulation and mitochondrial calcium handling in AD
Ana Cristina Rego
15:30-15:45 Break
15:45-16:30 Endoplasmic reticulum stress and AD
Cláudia MF Pereira
16:30-17:15 New therapeutic strategies with BACE1 inhibitors for AD
Armanda E. Santos
Wednesday (April 25) Holiday
Thursday (April 26) Movement disorders
09:30-10:30 Clinical challenges in Parkinson s and polyglutamine-expansion disorders
Cristina Januário
10:30-11:15 Mitochondria as a trigger of Parkinson´s disease
Sandra Morais Cardoso
11:15-11:30- Break
11:30-12:15 Adenosine receptors in Parkinson s disease
Rodrigo Cunha
12:15-14:00- Lunch
14:00-14:45 Machado-Joseph disease: from models to reversibility
Luís P. Almeida
14:45-15:30 Mouse and worm models of Machado-Joseph disease: tools for therapy development
Patrícia Maciel
15:30-15:45 Break
15:45-16:30 Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy.
Clévio Nóbrega
16:30-17:15 Impact of modifying sirtuin-3 in Huntington s disease
Ana Cristina Rego
Friday (April 27) Student s assessment and Seminar 2
09:00-09:30 Multiple-choice questionnaire
09:30-09:45 Break
09:45-11:45 Paper Presentations (max. 20 min/group + discussion)
11:45-12:15 Meet the expert with Paola Pizzo
12:15-14:00 Lunch
14:00-15:00 Seminar 2: ER-mitochondria cross-talk in neurodegeneration: focus on Familial Alzheimer s disease
Paola Pizzo
Address:
CNC Auditorium, 2nd floor, Faculty of Medicine, Polo 1, Rua Larga, University of Coimbra
Affiliations – Lecturers/Faculty (in alphabetical order):
Armanda E. Santos (aesantos@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
Carlos B. Duarte (cbduarte@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal
Rosário Almeida (mralmeida2008@gmail.com)
Center for Neuroscience and Cell Biology,
University of Coimbra, Coimbra, Portugal
Clévio Nóbrega (cdnobrega@ualg.pt)
Centre for Biomedical Research, University of Algarve, and
Center for Neuroscience and Cell Biology
University of Coimbra, Coimbra, Portugal
Cristina Januário (cristinajanuario@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC), and
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Elisabete Ferreiro (beferreiro@gmail.com)
Center for Neuroscience and Cell Biology
University of Coimbra, Coimbra, Portugal
Flaviano Giorgini (fg36@leicester.ac.uk)
Department of Genetics and Genome Biology
University of Leicester, Leicester, UK
Hugo Alexandre Ferreira (hugoferreira@campus.ul.pt)
Institute of Biophysics and Biomedical Engineering
Faculty of Sciences, University of Lisbon, Lisbon, Portugal
Isabel Santana (isabeljsantana@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC), and
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
João Laranjinha (laranjin@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
Jorge Ascenção Oliveira (jorgemao@ff.up.pt)
REQUIMTE, Dep. Drug Sciences, and
Faculty of Pharmacy, University of Porto, Portugal
Luís Pereira de Almeida (luispa@cnc.uc.pt; luispa@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
Patrícia Maciel (pmaciel@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho, Braga, Portugal
Paola Pizzo (paola.pizzo@unipd.it)
Department of Biomedical Sciences
University of Padova, Padova, Italy
Paula Agostinho (pmgagostinho@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Paula Isabel Moreira (pismoreira@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Rodrigo Cunha (cunharod@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Sandra M. Cardoso (cardoso.sandra.m@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Cláudia MF Pereira (claudia.mf.pereira@gmail.com; cpereira@cnc.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
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