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Neurodegenerative disorders
 
April 23 - 27
Coordinator: A Cristina Rego & Claudia Pereira

acrego@cnc.uc.pt ; claudia.mf.pereira@gmail.com
PDBEB course “Neurodegenerative disorders”
CNC Auditorium
April 23-27, 2018


Organizers:
Ana Cristina Rego and Cláudia MF Pereira


Objectives:
This course will focus on the latest research in the field of neurodegenerative diseases, by converging on the study of basic mechanisms of neurodegeneration that occur in Alzheimer s disease (AD), Parkinson s disease (PD), and polyglutamine expansion diseases (Ataxias and Huntington s disease). Moreover, clinical and neuropathological aspects, as well as therapeutic strategies of these disorders will be addressed.


Daily Programme:

Monday (April 23) Mechanisms of neuronal dysfunction and Seminar 1

09:00-09:30    Presentation of students and speakers. Presentation of student s assignments.
Ana Cristina Rego and Cláudia MF Pereira

09:30-10:00    Proteostasis pathways
Cláudia MF Pereira

10:00-10:45    Neuroinflammation and synaptotoxicity: a focus on astrocytes
Paula Agostinho

10:45-11:00    Break

11:00-11:45    Neuronal mitochondrial (dys)function
Jorge Oliveira

11:45-12:30    Nitric oxide-mediated signaling in neurological diseases
João Laranjinha

12:30-14:00    Lunch

14:00-15:00    Seminar 1: Targeting the kynurenine pathway in neurodegenerative diseases
Flaviano Giorgini

15:00-15:30    Break

15:30-16:15    Dysregulation of GABAergic synapses and excitototoxic neuronal death
Carlos B. Duarte

16:15-17:00    Use of fly models to study neurodegenerative diseases
Flaviano Giorgini

17:00-17:30    Meet the expert with Flaviano Giorgini


Tuesday (April 24)    Alzheimer s disease (AD)


09:30-10:15    Dementia: clinical aspects and clinical trials
Isabel Santana

10:15- 11:00    “Machine learning” for AD diagnosis
Hugo Alexandre Ferreira

11:00-11:15- Break

11:15-12:00    The genetic component of AD
Rosário Almeida

12:00-12:30    Neurogenesis in AD
Elisabete Ferreiro

12:30-14:00    Lunch

14:00-14:45    Metabolic dysfunction in AD
Paula Moreira

14:45-15:30    Redox regulation and mitochondrial calcium handling in AD
Ana Cristina Rego

15:30-15:45    Break

15:45-16:30    Endoplasmic reticulum stress and AD
Cláudia MF Pereira

16:30-17:15    New therapeutic strategies with BACE1 inhibitors for AD
Armanda E. Santos


Wednesday (April 25) Holiday



Thursday (April 26)    Movement disorders


09:30-10:30    Clinical challenges in Parkinson s and polyglutamine-expansion disorders
Cristina Januário

10:30-11:15    Mitochondria as a trigger of Parkinson´s disease
Sandra Morais Cardoso

11:15-11:30- Break

11:30-12:15    Adenosine receptors in Parkinson s disease
Rodrigo Cunha

12:15-14:00- Lunch

14:00-14:45    Machado-Joseph disease: from models to reversibility
Luís P. Almeida

14:45-15:30    Mouse and worm models of Machado-Joseph disease: tools for therapy development
Patrícia Maciel

15:30-15:45    Break

15:45-16:30    Polyglutamine diseases:  lessons from disease pathogenesis and clues into therapy.
Clévio Nóbrega

16:30-17:15    Impact of modifying sirtuin-3 in Huntington s disease
Ana Cristina Rego


Friday (April 27) Student s assessment and Seminar 2


09:00-09:30    Multiple-choice questionnaire

09:30-09:45    Break

09:45-11:45    Paper Presentations (max. 20 min/group + discussion)

11:45-12:15    Meet the expert with Paola Pizzo

12:15-14:00    Lunch

14:00-15:00    Seminar 2: ER-mitochondria cross-talk in neurodegeneration: focus on Familial Alzheimer s disease
Paola Pizzo


Address:
CNC Auditorium, 2nd floor, Faculty of Medicine, Polo 1, Rua Larga, University of Coimbra





Affiliations – Lecturers/Faculty (in alphabetical order):

Armanda E. Santos (aesantos@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

Carlos B. Duarte (cbduarte@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

Rosário Almeida (mralmeida2008@gmail.com)
Center for Neuroscience and Cell Biology,
University of Coimbra, Coimbra, Portugal

Clévio Nóbrega (cdnobrega@ualg.pt)
Centre for Biomedical Research, University of Algarve, and
Center for Neuroscience and Cell Biology
University of Coimbra, Coimbra, Portugal

Cristina Januário (cristinajanuario@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC), and
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Elisabete Ferreiro (beferreiro@gmail.com)
Center for Neuroscience and Cell Biology
University of Coimbra, Coimbra, Portugal

Flaviano Giorgini (fg36@leicester.ac.uk)
Department of Genetics and Genome Biology
University of Leicester, Leicester, UK

Hugo Alexandre Ferreira (hugoferreira@campus.ul.pt)
Institute of Biophysics and Biomedical Engineering
Faculty of Sciences, University of Lisbon, Lisbon, Portugal

Isabel Santana (isabeljsantana@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC), and
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

João Laranjinha (laranjin@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

Jorge Ascenção Oliveira (jorgemao@ff.up.pt)
REQUIMTE, Dep. Drug Sciences, and
Faculty of Pharmacy, University of Porto, Portugal

Luís Pereira de Almeida (luispa@cnc.uc.pt; luispa@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

Patrícia Maciel (pmaciel@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho, Braga, Portugal

Paola Pizzo (paola.pizzo@unipd.it)
Department of Biomedical Sciences
University of Padova, Padova, Italy

Paula Agostinho (pmgagostinho@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Paula Isabel Moreira (pismoreira@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Rodrigo Cunha (cunharod@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Sandra M. Cardoso (cardoso.sandra.m@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal


Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal

Cláudia MF Pereira (claudia.mf.pereira@gmail.com; cpereira@cnc.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra, Coimbra, Portugal
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