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Synapses, Neuronal Circuits and Behavior - Supported by FENS/IBRO-PERC
 
April 9 - 20
FENS and IBRO-PERC provides 4 stipends of 750 EUR for master and/or PhD students interested in attending this course.

This course is modular; students in the PDBEB and MBCM programs may opt to attend one of the weeks only (April 9-13: Molecular and Cellular Neuroscience; April 16-20: Neuronal Circuits and Behavior)
Synapses, neuronal circuits and behavior

FENS and IBRO-PERC
provides 4 stipends of 750 EUR for master and/or PhD students interested in attending this course.

Through these stipends FENS and IBRO-PERC aim to encourage and promote international experience of students; hence, students that are currently residing or studying in Portugal are not eligible for a FENS and IBRO-PERC stipend for this course. Apply here.



Date:
April 9-20, 2018

Location: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

Coordinators:

Ana Luísa Carvalho (alc@cnc.uc.pt); CNC, University of Coimbra
Carlos B. Duarte (cbduarte@ci.uc.pt); CNC, University of Coimbra
João Peça (jpeca@cnc.uc.pt); CNC, University of Coimbra

Lecturers
Albino Maia, Champalimaud Foundation, Lisbon, Portugal ORCID; Lab
Ana Luísa Cardoso, CNC, University of Coimbra, Portugal ORCID;
Ana Luísa Carvalho, CNC, University of Coimbra, Portugal ORCID; Lab
Ana M. Oliveira, Department of Neurobiology, University of Heidelberg, Germany ORCID; Lab
Ana M. Sebastião, IMM, University of Lisbon, Portugal ORCID; Lab
Carlos Duarte, CNC, University of Coimbra, Portugal ORCID; Lab
Fernando Lopes da Silva, University of Amsterdam, The Netherlands
João Peça, CNC, University of Coimbra, Portugal ORCID; Lab
Joe Paton, Champalimaud Foundation, Portugal ORCID; Lab
Luísa Cortes, CNC, University of Coimbra, Portugal ORCID
Luisa Pinto, ICVS, University of Minho, Portugal ORCID; Lab
Miguel Remondes, IMM, University of Lisbon, Portugal ORCID; Lab
Patrícia Monteiro, ICVS, University of Minho, Portugal  Lab
Paulo Pinheiro, CNC, University of Coimbra, Portugal ORCID; Lab
Ramiro D. Almeida, CNC, University of Aveiro, Portugal ORCID
Ricardo Rodrigues, CNC, University of Coimbra, Portugal ORCID; Lab
Rui Ponte Costa, Univ. of Oxford, UK and Univ. of Bern, Switzerland ORCID; Lab
Susana Lima, Champalimaud Foundation, Portugal Lab
Vasco Galhardo, University of Porto, Portugal ORCID; Lab



Aims
The aim of this course is to provide an integrated view into the functioning of neuronal synapses and circuits, and the methodologies used to probe how neural networks assemble and communicate with one another. A second aim is to address questions related to how neuronal computations give rise to behavioral outputs and perceptions. Teaching will be based on lectures that focus on 1) synapse assembly, function and plasticity; 2) particular circuits or brain region and the underlying behavioral programs; and 3) disorders associated with synaptic dysfunction and circuits malfunction. The students will gain knowledge on how information in coded in the brain and how it is propagated, and will be introduced to the state of the art methodologies applied in the field of neuroimaging, neurophysiology and behavioral analysis. This will include discussion and exploration of practical examples on the application of techniques such as: in vivo recordings with multi-electrode arrays, local field potential analyses, brain imaging, optogenetics, genetic engineering or multi-photon microscopy.
At the University of Coimbra this course is offered to students in the Doctoral Program in Experimental Biology and Biomedicine and in the MIT-PT Bioengineering Doctoral Program, and to students in the Master Program in Molecular Cell Biology. The course is also offered to students supported by FENS and IBRO-PERC stipends.

COURSE SYLLABUS

April 9
9.00h-9.15h: Structure of the course; Introduction of students and lecturers
9.15h-10.45h: Neuronal migration: inter- and intracellular signaling. Ricardo Rodrigues
11.00h-12.30h: Molecular triggers of synapse formation and maturation - Ramiro D. Almeida

14.00h-15.30h: Electrophysiology: a primer (I) - João Peça
16.00h-17.30h: Electrophysiology: a primer (II) - Paulo Pinheiro

April 10
9.00h-10.30h: Introduction to synapses: structure-function and molecular composition - Ana Luisa Carvalho
11.00h-12.30h: Presynaptic function - Paulo Pinheiro

14.00h-15.30h: Postsynaptic receptor function - Ana Luisa Carvalho
16.00 -17.00h: Synaptic plasticity & molecular mechanisms -Ana Luísa Carvalho

April 11
9.00h-10.30h: Modelling synaptic plasticity - Rui Ponte Costa
11.00h-12.30h: Modelling synaptic plasticity (practical session) - Rui Ponte Costa

14.00h-15.30h: Molecular mechanisms in long-term memory formation – Ana Oliveira
16.00h-17.30h: Synaptic sculpting by microglia in health and disease – Ana Luisa Cardoso

April 12

9:00h - 10.00h - Multi-photon microscopy: principles and applications; Live imaging of neurons and synapses in vivo - Luisa Cortes

10:30h - 17:30h: Practical sessions
(1) Electrophysiology - Measurement of synaptic parameters in rat hippocampal slices and in cultured rat hippocampal neurons - Paulo Pinheiro & João Peça/Joana Guedes
(2) Two-photon microscopy - Imaging spine dynamics in organotypic hippocampal slices - Luísa Cortes

April 13
9.00h-10.00h: The memory engram – Ana Oliveira
10.30h-12.00h: Neuromodulation - Carlos Duarte

14.00h - 15.00h - DNA methylation players in memory formation. Seminar by Ana M.M. Oliveira
15.30h - 16.30h: Principled views on synapses and circuits: statistical and deep learning – Seminar by Rui Ponte Costa
17.00h: Time to meet with tutors for grant proposal

April 16
9.30h-10.00h: Introduction to the second week of the course and objectives – João Peça
10.00-11.00h: Optogenetics and tools for neuronal circuit dissection – João Peça
11.15-12.15: Synaptic and circuitry mechanisms of basal ganglia dysfunction – Patricia Monteiro

14.00h-14.45h: Lab talks (talks from senior Postdoc or Student)
Studying human neurons in the lab – Catarina Seabra
15.00-16.00h: Brain Rhythms: networks, cognitive functions and multimodal functional imaging – Fernando Lopes da Silva
16.15-17.00h “Advise for Young Scientist” – Q&A with Fernando Lopes da Silva

April 17
9.30h-16.30h: Practical sessions
(1) Electrophysiology - Measurement of synaptic parameters in rat hippocampal slices and in cultured rat hippocampal neurons - Paulo Pinheiro & João Peça/Joana Guedes
(2) Two-photon microscopy - Imaging spine dynamics in organotypic hippocampal slices - Luísa Cortes

April 18
9.30h-10.30h: Neuropsychiatry and brain stimulation – Albino Maia
10.30h-11.30h: Brain maps for choice behaviors - Miguel Remondes
11.45h-12.45h: Dopaminergic Modulation of Cognitive Processing in Pain – Vasco Galhardo

14.00h-14.45h: Lab talks (talk from senior Postdoc or Student)
15.00-16.00h: Seminar by Joe Paton (A Neural population code for time in the striatum)

April 19
9.00h-10.00h: Synaptic dysfunction in neuropsychiatric disorders – Ana Luísa Carvalho
10.00h-11.00h: Modulation of GABAergic inhibitory inputs in the hippocampus – Ana Sebastião
11.15h-12.15h: Mate choice and hypothalamic circuits – Susana Lima

14.00h-14.45h: TBA
15.00-16.00h: Seminar by Luisa Lopes (Title TBA)

April 20
10.00h-10.45h: Genetic dissection of autism spectrum disorders – João Peça
11.00h-11.45h: Lab talks (talk from senior CNC Postdoc or PhD Student)

14.00h-14.45h: Seminar - TBA


Grant proposal Deadline – 22 April 2018

Student Assignments:
The students (in groups of 2-3) will write a grant proposal based on original papers that will be proposed to them. The grant proposal is 3 pages long and should include the following sections: a) State of the art; b) Objectives of proposal; 3) Proposed tasks and methodology. Throughout the course the students will meet with tutors for discussing the grant proposal.

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