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Neuroscience and Mental Health: a clinical and molecular perspective
 
May 9 - 13
Coordinators: Ana Cristina Rego (arego@fmed.uc.pt; a.cristina.rego@gmail.com) and António Freire (afreireg@hotmail.com)
Neuroscience and Mental Health: a clinical and molecular perspective
(Neurociências e Saúde Mental: uma perspetiva clínica e molecular)
[2015-2016 edition]

The PhD Programme in Health Sciences (PhDHS), Interuniversitary PhD Programme in Aging and
Chronic Diseases (PhDOC) and Doctoral Program in Experimental Biology and Biomedicine (PDBEB)

Faculty of Medicine & Center for Neuroscience and Cell Biology, University of Coimbra

Dates (1 week): May 9-13, 2016

Local: IBILI Auditorium (Pólo III – Pólo das Ciências da Saúde, Azinhaga de Santa Comba, Celas)

Coordinators: Ana Cristina Rego (arego@fmed.uc.pt; a.cristina.rego@gmail.com) and António Freire
(afreireg@hotmail.com)

Programme:

Monday (May 9)
14:00 – 14:15 Welcome and Introduction to the course (Ana Cristina Rego & António Freire)
14:15 – 14:45 Psychiatric diseases and behavior – a genetic approach (António de Macedo, FMUC)
14:45 – 15:00 Discussion
15:00 – 15:30 Translational research in neurodevelopmental disorders – the case of autism
(Guiomar Oliveira, FMUC and CHUC)
15:30 – 15:45 Discussion
15:45 – 16:00 Break
16:00 – 16:45 Synaptic dysfunction in schizophrenia and autism (João Peça, CNC-IBILI)
16:45– 17:15 Imaging in neuropsychiatric diseases (Miguel Castelo-Branco, FMUC & CNC-IBILI)
17:15 – 17:30 Discussion

Tuesday (May 10)
13:15– 13:35 Student´s assignment: Presentation of paper #1 (Group 1)
13:35 – 13:45 Discussion
14:00 – 14:45 Acidente Vascular Cerebral (Luís Cunha, FMUC & CHUC)
14:45 – 15:30 Molecular basis of ischemia (Carlos B. Duarte, FCTUC & CNC-IBILI)
15:30 – 15:45 Discussion
15:45 - 16:00 Break
16:00 – 16:30 Clinical aspects of demyelinating diseases – the case of multiple sclerosis (Lívia Sousa)
16:30 – 17:00 Body fluid biomarkers in multiple sclerosis (Inês Baldeiras)
17:00 - 17:45 Regulation of myelination and remyelination of the central nervous system (João
Bettencourt-Relvas, IBMC & i3S)
17:45 – 18:00 Discussion

Wednesday (May 11)
13:15– 13:35 Student´s assignment: Presentation of paper #2 (Group 2)
13:35 – 13:45 Discussion
14:00 – 15:00 Common molecular and cellular basis of neurodegenerative diseases (Catarina R.
Oliveira, FMUC & CNC-IBILI)
15:00-15:15 Discussion
15:15 – 16:00 Molecular mechanisms underlying pathogenesis in Huntington´s disease (Flaviano
Giorgini, Univ Leicester, UK)
16:00 – 16:30 Modulation of sirtuins in models of Huntington´s disease – a focus on mitochondrial
function and dynamics (A. Cristina Rego, FMUC & CNC-IBILI)
16:30 – 17:15 Challenging animal models of Machado-Joseph disease (Patrícia Maciel, ICVS-Univ.
Minho)
17:15 – 17:30 Discussion

Thursday (May 12)
12:00 – 12:25 Clinical aspects of polyglutamine-expansion disorders (Cristina Januário, FMUC &
CHUC)
12:25 – 12:50 Clinical aspects of Parkinson´s disease (António Freire, FMUC & CHUC)
13:15– 13:35 Student´s assignment: Presentation of paper #3 (Group 3)
13:35 – 13:45 Discussion
14:00 – 15:00 Seminar 1: Targeting the kynurenine pathway in neurodegenerative disease (Flaviano Giorgini, Univ. Leicester, U.K.)
15:00 – 15:15 Discussion
15:15– 15:30 Break
15:30 – 16:00 Genetic variability in Parkinson´s disease – a focus on LRRK2 (Sandra Cardoso, FMUC
& CNC-IBILI)
16:00 – 16:30 Novel targets for Parkinson´s disease: DJ-1 binding partners under oxidative stress
(Bruno Manadas, CNC-IBILI)
16:30 – 16:45 Break
16:45 – 17:30 Chronic stress and synaptic malfunction in Alzheimer´s disease - a gate along the
path from depression to dementia (Ioannis Sotiropoulos, ICVS & Univ. Minho)
17:30 – 18:00 Clinical aspects in dementia and Alzheimer´s disease (Isabel Santana, FMUC & CHUC)
18:00 – 18:15 Discussion

Friday (May 13)
13:15– 13:35 Student´s assignment: Presentation of paper #4 (Group 4)
13:35 – 13:45 Discussion
14:00 – 15:00 Seminar 2: Tauopathies and tau-based therapeutic strategies (Miguel Medina,
CiberNed, Madrid, Spain
)
15:00 –15:15 Discussion
15:15 – 16:15 Seminar 3: New advances in the therapy of multiple sclerosis (Lucienne Costa Frossar, Hospital Ramon y Cajal, Madrid, Spain)
1615 - 16:30 Discussion
16:30 – 17:00 Student´s assignment: Multiple-choice questionnaire

Student´s assignments and distribution in Groups:

The students (Groups 1-4) will be asked to present an original paper and critically analyze the data, as well as to propose additional relevant experiments and their specific rationale and objectives as a mini-project proposal (orally presented).
Each group will have up to 20 min for each presentation, which will be followed by ~10 min
discussion.

Original papers and student´s names (4 groups):

Group 1: Ana Cristina Duque, Luís Miguel Bajouco, Raquel Boia

Paper 1: Peixoto RT, Wang W, Croney D, Kozorovitskiy Y, Sabatini BL (2016) Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B-/- mice. Nat. Neurosci. [Epub
ahead of print] doi: 10.1038/nn.4260

Group 2: Sónia Moreira, Vasco Nogueira, Carla Henriques

Paper 2: Hill MD, Martin RH, Mikulis D, Wong JH, Silver FL, Terbrugge KG, Milot G, Clark WM,
Macdonald RL, Kelly ME, Boulton M, Fleetwood I, McDougall C, Gunnarsson T, Chow M, Lum C,
Dodd R, Poublanc J, Krings T, Demchuk AM, Goyal M, Anderson R, Bishop J, Garman D, Tymianski M; ENACT trial investigators (2012) Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 11: 942-950. doi: 10.1016/S1474-4422(12)70225-9.

Group 3: Carla Marques, Joana Perdigão

Paper 3: Babcock DT and Ganetzky B (2015) Transcellular spreading of huntingtin aggregates in the Drosophila brain. Proc Natl Acad Sci U S A. 112: E5427-33. doi: 10.1073/pnas.1516217112.

Group 4: Inês Mesquita, Joana Andrade, Ricardo Martins

Paper 4: Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI (2014) Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82(6): 1271-88.
doi: 10.1016/j.neuron.2014.04.047.

Evaluation:
Students will be evaluated based on the oral presentation and on the ability to establish an
interactive participation along the course, namely by frequently questioning the lecturers. The final
grade in the course will be also based on the mark obtained in the multiple choice questionnaire
(held in the last day of the course).

The evaluation criteria (max. 20 values) will include:
- Presence (0-1; 0 will be given to less than 70% course attendance)
- Participation – questions to lecturers (0-4)
- Paper discussion (0-10): *Data presentation (0-2); *Critical view (0-4); *Proposed experimental
research (0-4).
- MC Questionnaire (0-5)

Faculty names and affiliations:

External to the University of Coimbra

Flaviano Giorgini (PhD) - Department of Genetics, University of Leicester, Leicester, LE1 7RH, U.K. E-mail: fg36@leicester.ac.uk

Ioannis Sotiropoulos (PhD) – ICVS, at University of Minho, Braga, Portugal - E-mail: ioannis@ecsaude.uminho.pt

João Bettencourt Relvas (PhD) – IBMC and i3S, University of Porto, Porto, Portugal - E-mail: jrelvas@ibmc.up.pt

Lucienne Costa Frossar (MD, PhD) - Hospital Ramon y Cajal, Madrid
E-mail: lufrossard@yahoo.es


Miguel Medina (PhD) – Ciberned, Madrid, Spain - E-mail: mmedina@ciberned.es

Patrícia Maciel (PhD) - ICVS, at University of Minho, Braga, Portugal - E-mail: pmaciel@ecsaude.uminho.pt

From the University of Coimbra

Ana Cristina Rego (PhD) - Center for Neuroscience and Cell Biology, and Faculty of Medicine,
University of Coimbra, Coimbra, Portugal - E-mail: a.cristina.rego@gmail.com; acrego@cnc.uc.pt; arego@fmed.uc.pt

António de Macedo (MD, PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal
E-mail: amacedo@ci.uc.pt

António Freire (MD, PhD) - University Hospital of Coimbra (HUC), Neurology Service, Faculty of
Medicine, University of Coimbra, Coimbra, Portugal - E-mail: afreireg@hotmail.com

Bruno Manadas (PhD) - Center for Neuroscience and Cell Biology (CNC), University of Coimbra and UC Biotech - Parque Tecnológico de Cantanhede, Portugal - E-mail: bmanadas@gmail.com

Carlos B. Duarte (PhD) - Center for Neuroscience and Cell Biology (CNC), and Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal - E-mail: cbduarte@ci.uc.pt

Catarina R. Oliveira (MD, PhD) - Center for Neuroscience and Cell Biology (CNC), and Faculty of
Medicine, University of Coimbra, Coimbra, Portugal - E-mail: catarina.n.oliveira@gmail.com

Cristina Januário (MD, PhD) - University Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal - E-mail: cristinajanuario@gmail.com

Guiomar Oliveira (MD, PhD) - University Hospital of Coimbra (HUC), Faculty of Medicine, University of Coimbra, Coimbra, Portugal - E-mail: guiomar@chc.min-saude.pt

Inês Baldeiras (PhD) - Laboratory of Neurochemistry, University Hospital of Coimbra (HUC), and
Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal - E-mail: ines.baldeiras@sapo.pt

Isabel Santana (MD, PhD) - University Hospital of Coimbra (HUC), Neurology Service, Faculty of
Medicine, University of Coimbra, Coimbra, Portugal - E-mail: isabeljsantana@gmail.com

João Peça (PhD) - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal - E-mail: jmpessa@gmail.com

Lívia Sousa (MD) - University Hospital of Coimbra (HUC), Neurology Service, Coimbra, Portugal
E-mail: livia.sousa@netcabo.pt

Luís Cunha (MD, PhD) - Faculty of Medicine, University of Coimbra, and University Hospital of
Coimbra (HUC), Neurology Service, Coimbra, Portugal - E-mail: cunhaluis0@gmail.com

Miguel Castelo-Branco (MD, PhD) - Institute for Biomedical Imaging and Life Sciences, Faculty of
Medicine, University of Coimbra, Coimbra, Portugal - E-mail: mcbranco@fmed.uc.pt

Sandra M. Cardoso (PhD) - Center for Neuroscience and Cell Biology, and Faculty of Medicine,
University of Coimbra, Coimbra, Portugal - E-mail: cardoso.sandra.m@gmail.com
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