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Metabolism and Aging
April 4 - 8
João Ramalho-Santos, Paulo J. Oliveira
BEB Course “Metabolism and Aging”,

Organized by the Metabolism, Aging and Disease area
(João Ramalho-Santos, Paulo J. Oliveira)

Former Phisiology Auditorium, FMUC, POLO I, 1st floor

Monday, April 4
10:00 - Cláudia Cavadas (FFCU/CNC) Hypothalamus and aging
11:00 – Cláudia Cavadas (FFCU/CNC) Progeria: from pathophysiology to new therapeutic strategies
14:00 – Jose Vina (U. Valencia, Spain) Aging is normal: reflections of a gerontologist
15:00 – Jose Vina (U. Valencia, Spain) Nutritional approach to ApoE directed therapeutics in Alzheimer’s disease
16:00 – Interaction time

Tuesday, April 5
10:00 - Vilma Sardão (CNC) Cardiometabolic alterations during menopause
11:00 – Paula I. Moreira (FMUC/CNC) How does diabetes affect the brain?
14:00 – João Ramalho-Santos (FCTUC/CNC) Epigenetics, aging and infertility
15:00 – A. Sofia Rodrigues (CNC) Metabolic modulation of pluripotency as a possible tool to prevent aging
16:00 - Interaction time

Wednesday, April 6

10:00 – Paulo J. Oliveira (CNC) Delaying mitochondrial disruption in aging
11:00 - João Teodoro (CNC) Lipotoxicity, metabolism and aging: current and future prospects
14:00 – John Jones (CNC) Noninvasive measurements of metabolic fluxes in humans using NMR and stable isotope tracers
15:00 – Ana Burgeiro/Ermelindo Leal (CNC) Diabetes and its macro- and microvascular complications
16:00 - Alexandrina Mendes (FFUC/CNC) Aging and diabetes as risk factors for osteoarthritis or how diabetes accelerates chondrocyte aging and joint damage

Thursday, April 7
10:00 – Inês Aleixo (CIAFEL, FDUP) Physical activity as a means to prevent metabolic disruption in aging
11:00 – General discussion: Is physical activity important for healthy aging?
14:00 – Ruben Nogueiras (University of Santiago de Compostela, Spain) Central regulation of energy balance
15:00 - Ruben Nogueiras (University of Santiago de Compostela, Spain) Ghrelin and energy balance: pharmacological versus physiological effects.
16:00 - Interaction time

Friday, April 8
10:00 – 13:00: Work presentations by students

Evaluation of the course:

Students will be paired in groups of two and asked to comment in one scientific paper related with the topic of the course (Metabolism and Aging). The list of papers will be made available before the course starts.
SIX minutes are available for each group for pitching the virtues of the paper and request funds for a study follow-up.
One student should describe the novel and strong points of the study (3 minutes) while the second student should pitch for getting research money (how much?) for the study follow-up, indicating future strategies and the weaknesses of the study that should now be corrected (3 minutes also).
Powerpoint slides can be used (or qithout any support), and the time allocated for each group will be strictly enforced.

(if there any any Master students interested in this course, please contact pauloliv@cnc.uc.pt for work attributions)

1 - Maria Inês Martins/Ana Raquel Coelho - Satapi et al (2015) Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J. Clin. Invest. 125 (12): 4447-4462

2 - Marcos Gomes/Cláudia Deus - Akhtar et al (2016) Elevated glucose and oligomeric beta-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature Commun. 7:10242 - DOI: 10.1038/ncomms10242

3 - Luís Martins/João Amorim - Sivasinprasasn et al (2015) Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats. Age. 37: 28.

4 - Candida Dias/(to be defined) - Teodoro et al (2014) Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice. Int. J. Obes. 38(8):1027-34.

5 - Cátia Seabra/Margarida Ribeiro - Gioscia-Ryan et al. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J. Physiol. 592 (12): 2549-2561.

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