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Neurodegenerative diseases: From molecules to clinics and beyond
 
October 29 - November 2
Ana Cristina Rego (acrego@cnc.cj.uc.pt), Paula Agostinho, Luís Pereira de Almeida, Cláudia MF Pereira

Neurodegenerative diseases: From molecules to clinics and beyond

October 29 – November 2, 2012


Monday (Oct 29) – Alzheimers disease (AD)

9:00-9:30- Presentation of students and speakers. Presentation of students assignments.

9:30-10:15- Introduction to neurodegenerative diseases. Mechanisms of neuronal dysfunction: the paradigm of excitotoxicity in AD.
Ana Cristina Rego

10:15-10:30- Break

10:30-11:15- Endoplasmic reticulum stress and AD
Claudia Pereira

11:15-12:00- Metabolic dysfunction in AD
Paula Moreira

12:00-14:00- Lunch

14:00-14:45- Translational research in AD
Inês Baldeiras

14:45-15:15- Break

15:15-16:00- Clinical aspects of AD and clinical trials
Isabel Santana

Tuesday (Oct 30) – AD and Parkinsons disease (PD)

9:30-10:15- Neuroinflammation in AD
Jeroen Hoozemans

10:15-10:30- Break

10:30-11:15- The unfolded protein response in AD, PD and Fronto-Temporal Lobar Degeneration (FTLD)
Jeroen Hoozemans

11:15-12:00- Amyloid-beta and prion peptides neurotoxicity
Paula Agostinho

12:00-13:45- Lunch
 
13:45-14:30- Pathogenesis of PD
Sandra M. Cardoso

14:30-14:45- Break

14:45-15:30- Clinical aspects of PD
Cristina Januário

15:30-15:45- Break

15:45-16:30- Deep brain stimulation: from the experience in PD to most recent indications and future developments
Rui Vaz

Wednesday (Oct 31) – PolyQ disorders– Huntingtons disease (HD) and Machado-Joseph disease (MJD)

9:30-10:30- Neurobiology of HD - Reversibility and pathogenesis
Jose Lucas

10:30-10:45 - Break

10:45-11:15- Pyruvate dehydrogenase in HD
Cristina Rego

11:15-12:00- MJD: from models to reversibility
Luís P. Almeida

12:00-14:00- Lunch

14:00-15:00- SEMINAR: The ubiquitin-proteasome system in HD
Jose Lucas

15:00-15:30- Break

15:30-16:15- Mouse and worm models of MJD: tools for therapy development.
Anabela Fernandes

16:15-17:00- Clinical aspects of HD and ataxias
Cristina Januário

Thursday (Nov 1)- Holiday

Friday (Nov 2) - Evaluation

9:30-10:00- Multiple-choice examination

10:00-10:30- Break

10:30-12:30- Presentations (max. 30 min/group)

12:30-14:00- Lunch

14:00-15:00- Presentations (max. 30 min/group)

Students Assignments and Distribution
The evaluation criteria will include:
- Multiple choice examination (5 in 20)
- Participation (questions/commentaries) during the course (5 in 20)
- Paper presentation, including critical review and proposal of future work (10 in 20)

Group 1 – Andreia Marques Gomes, Jeannette Schmidt, RaviKumar Kapavarapu, Emanuel Candeias, Pedro Batista
Wang S, Xu B, Liou LC, Ren Q, Huang S, Luo Y, Zhang Z, Witt SN. α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16119-24.

Group 2 – Dina M.ª Silva Pereira, Lara Oliveira Franco, Sofia Alexandra Ferreira, Cátia Santa, Ricardo Silva
Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides. Neuron. 2012 Sep 6;75(5):824-37.

Group 3 – Gladys Tarcila Caldeira, Mohamed Edfawy Hussien, Sara Raquel Reis Oliveira, Vítor Carmona, Cristina Lemos
Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012 Jul 2;9(1):151.

Group 4 – Ivan Lalanda Salazar, Patrícia Sofia Alçada Morais, Susana Filipa Sampaio, Patrícia Albuquerque, Joana Pedro
Shirendeb UP, Calkins MJ, Manczak M, Anekonda V, Dufour B, McBride JL, Mao P, Reddy PH. Mutant huntingtins interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntingtons disease. Hum Mol Genet. 2012 Jan 15;21(2):406-20.

Name 

Andreia Marques Gomes 
BEB PhD student

Dina M.ª Silva Pereira 
BEB PhD student

Gladys Tarcila Caldeira 
BEB PhD student

Ivan Lalanda Salazar 
BEB PhD student

Jeannette Schmidt 
BEB PhD student

Lara Oliveira Franco 
BEB PhD student

Mohamed Edfawy Hussien 
BEB PhD student

Patrícia Sofia Alçada Morais 
BEB PhD student

RaviKumar Kapavarapu 
BEB PhD student

Sofia Alexandra Ferreira 
BEB PhD student

Sara Raquel Reis Oliveira 
BEB PhD student

Susana Filipa Sampaio 
BEB PhD student

Emanuel Candeias 
Extra-BEB PhD student

Ricardo Silva
Extra-BEB PhD student

Cátia Santa
Extra-BEB PhD student

Joana Pedro 
Extra-BEB PhD student

Patrícia Albuquerque
Extra-BEB PhD student

Pedro Batista 
Extra-BEB PhD student

Vítor Carmona 
Extra-BEB PhD student

Cristina Lemos 
Extra-BEB PhD student

Affiliations  Lecturers:
José Lucas (jjlucas@cbm.uam.es)
Centro de Biología Molecular Severo Ochoa (CBM/SO),
CSIC/UAM, Madrid, Spain

Jeroen Hoozemans (jjm.hoozemans@vumc.nl)
VU University Medical Center
Amsterdam, The Netherlands

Rui Vaz (ruimcvaz@gmail.com)
Neurosurgery Service of S. João Hospital
Faculty of Medicine, University of Porto
Porto, Portugal

Anabela Fernandes (anabelasf@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho
Braga, Portugal

Inês Baldeiras (ines.baldeiras@sapo.pt)
Laboratory of Neurochemistry
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Cristina Januário (cristinajanuario@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Isabel Santana (isabeljsantana@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Sandra M. Cardoso (scardoso@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Paula Isabel Moreira (pismoreira@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) – Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Cláudia MF Pereira (claudia.mf.pereira@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Luís Pereira de Almeida (luispa@cnc.uc.pt; luispa@ci.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal

Paula Agostinho (pmgagostinho@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

 

 

 

 

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