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Biology of proteolysis in pathology
December 10 - 14
(Sandra Cardoso - cardoso.sandra.m@gmail.com, Paula Moreira, Ana Raquel Esteves)

Biology of proteolysis in pathology

Organizers: Sandra Morais Cardoso (cardoso.sandra.m@gmail.com); Paula Moreira
 (pismoreira@gmail.com); A. Raquel Esteves (esteves.raquel@gmail.com)

A Raquel Esteves (CNC, University of Coimbra, Coimbra, Portugal)
Ana Cristina Rego (CNC and Faculty of Medicine, University of Coimbra, Coimbra, Portugal)
Claudia Pereira (CNC and Faculty of Medicine, University of Coimbra, Coimbra, Portugal)
Inês Araújo (University of Algarve)
Margarida Caldeira (CNC and Faculty of Sciences, University of Coimbra, Coimbra, Portugal)
Marta Martinez-Vicente (Vall d Hebron Research Institute-Center for Networked Biomedical Research on Neurodegenerative Diseases, Barcelona, Spain)
Miquel Vila (Vall d Hebron Research Institute-Center for Networked Biomedical Research on Neurodegenerative Diseases, Barcelona, Spain)
Paula Moreira (CNC and Faculty of Medicine, University of Coimbra, Coimbra, Portugal)
Sandra Morais Cardoso (CNC and Faculty of Medicine, University of Coimbra, Coimbra, Portugal)

Organization and Goals
The Course lectures will be open to the general public and Grant Proposal discussions will be made by student with pre-assigned papers. Those are open to all CNC-PhD students, not only BEB students. Who wish to attend/be evaluated (please contact the course coordinator).

10th to 14th December

9h30: Introduction to the course, summary of course goals and student goals.
Tutorial distribution of papers relevant to the course.
10h00-11h00: Introduction to the Biology of Proteolysis
Sandra Morais Cardoso
11h00-11h15: Break
11h15-12h15: Proteolysis mediated by calpains
Inês Araújo
16h00-17h30: Grant Proposal with Inês Araújo (Group 1)

10h00-11h00: Ubiquitin Proteasome System in Ischemic Conditions
Margarida Caldeira
11h00-11h15: Break
11h15-13h00: Grant Proposal with Margarida Caldeira (Group 2)
14h00-15h00: Endoplasmic reticulum-associated degradation in pathology 
Cláudia Pereira
15h15-16h30: Grant Proposal with Claudia Pereira (Group 3)

9h30-10h30: Autophagy 1
Marta Martinez-Vicente
10h30-10h45: Break
10h45-11h45: Autophagy 2
Marta Martinez-Vicente
11h45-12h00: Break
12h00-13h30: Grant Proposal with Marta Martinez-Vicente (Group 4)
15h00-16h00: LRRK2 regulation of macroautophagy
A Raquel Esteves
16h00-16h15: Break
16h15-17h00: Modulation of macroautophagy by mitochondria
Sandra M Cardoso

10h30-11h45: Autophagy in Insulin resistance
Paula Moreira
11h45-12h00: Break
12h00-13h00: Apoptosis as the final proteolytic pathway
Ana Cristina Rego
14h30-16h00: Grant Proposal with Paula Moreira (Group 5)
16h00-17h30: Grant Proposal with A Cristina Rego (Group 6)

10h00-12h30: Invited to attend to Daniela Arduino PhD thesis discussion entitled Mitochondria and Protein Homeostasis in Parkinsons disease: from quality control pathways to an integrated network.
14h30-14h45: ER involvement in proteolysis
Ana Catarina Fonseca
14h45-15h00: Autophagy in Diabetes
Renato Xavier Santos
15h00-15h15: UPS dysfunction in PD
Diogo Martins-Branco
15h15-15h30: Effect of Preconditioning on autophagy
Sónia Correia

16h00:CNC Seminar at CNC Auditorium
Molecular mechanisms of neurodegeneration in Parkinsons disease
Miguel Vila


Grant Proposals, How?
Presentation should be prepared together and given together—one presentation per group. Presenters should compose a brief draft of a mock grant or fellowship proposal. Three specific Aims is often a good number though anywhere from 2-5 can be quite reasonable. These aims should be listed in bullet point form underneath the title of the proposal. You may also employ sub-aims if you prefer (Aim 1A, Aim 1B, etc). Take care that the proposal has a sensible structure: the title should outline the major and general aim, which should be accomplished via several more specific aims, which themselves will be achieved by means of specific experiments.
The proposal should not entirely hinge on one experiment that may or may not work. The proposal should not be narrow but should address a significant issue in a deep manner, leading to a new level of understanding of that problem. A clearly defined hypothesis will help in developing your proposal. The text version of the proposal should be one page maximum, essentially an abstract of the proposal. The subject matter should be related in some way to the paper assigned. Direct follow-up is OK, but make sure there are new ideas there. Feasibility and creativity are both important in evaluating the proposal, but creativity more so. Try not to only propose familiar experiments. Consider multiple approaches for testing your hypothesis (for example, combining genetic and biochemical approaches).
Prepare a powerpoint presentation outlining the proposal and diagramming some of the central experiments you propose. Consider in this powerpoint version necessary controls and pitfalls, and the significance of the project you propose.
Non-presenters should discuss the merits of the proposed experiments—whether the problem is a good one, whether the experiments effectively address the problem and will give interpretable results, whether they could actually be done in practice, whether necessary controls have been provided, whether still other experiments should be considered, and, assuming that everything goes to plan, whether the information gained would deliver a significant advance in our understanding of the subject matter.

Group 1 (paper1)
Andreia Marques Gomes andreiagomes@ua.pt
Mohamed Edfawy Hussien M_edfawy@yahoo.com
Emanuel Candeias (eu.emago@hotmail.com)
Ana Ribeiro (anacbjribeiro@gmail.com)

PDF1 (Paper1-Brain-2012-Simoes.pdf)

Group 2 (paper2)
Dina Mª Silva Pereira dina.pereira86@gmail.com
Patrícia Sofia Alçada Morais vertigo.alianora@gmail.com
Geetha Vijayakumar (geetha13surya@googlemail.com)
Francisco Queiroz (francisco.queiroz.goncalves@gmail.com)

PDF2 (Paper2-Mol Cell Biology, 29, 1774 (2009)[1].pdf)

Group 3 (paper3)
Gladys Tarcília Caldeira gladys_tlc@hotmail.com
RaviKumar Kapavarapu ravik4941@gmail.com
Diana Cruz (dvmc91@gmail.com)
Cátia Santa (catiajmsanta@gmail.com)

PDF3 (Paper3-J Neurosci_2012_RyR.pdf)

Group 4 (paper4)
Ivan Lalanda Salazar ivan.lalanda@gmail.com
Sara Raquel Reis Oliveira sararroliveira@gmail.com
Maria do Céu Lourenço (mceu_1989@hotmail.com)
Sandra Anjo (sandra.isabel.anjo@gmail.com)

PDF4 (Paper4-Rodriguez-Navarro. PNAS 2012[1].pdf)

Group 5 (paper5)
Jeannette Schmidt netti.schmidt@live.de
Sofia Alexandra Ferreira aferreira.sofia@gmail.com
*Aluno Grupo Mecanismos Moleculares de Doença e Envelhecimento
*Aluna Grupo de Vetores

PDF5 (Paper5-J. Biol. Chem.-2011-BEB.pdf)

Group 6 (paper6)
Lara Oliveira Franco lara_oliveira_franco@hotmail.com
Susana Filipa Sampaio susana.lipa@gmail.com
*Aluno Grupo Mecanismos Moleculares de Doença e Envelhecimento

PDF6 (Paper6-Pannaccione et al (JN-Aug12)Abeta_NCX3 fragm_neuronal death[1].pdf)

* Contact Course organizers

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