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Membrane Traffic and Disease
February 18 - 22
(Otília Vieira - vieira@cnc.uc.pt, Henrique Girão, Winchil Vaz)

Membrane Traffic and Disease

Coordinator: Otília V. Vieira (vieira@cnc.uc.pt)

 February 18 to 22, 2013

Why a Course on this subject:

Membrane traffic plays important roles in the physiology of cells and organisms. Many inherited and somatic diseases result from defects in membrane traffic pathway(s). Some pathogens are destroyed by these pathways, while others subvert their function during infection. Moreover, these pathways play key roles in both the stimulation and implementation of immune responses.
This workshop on Membrane Traffic and Disease will bring together experts from different Institutions in Portugal and Europe to discuss the most recent advances in the field, with a view to better understand the biology/physiology and pathophysiology of membrane traffic related diseases. Membrane traffic has taken center-stage in the pathogenesis of many important diseases. In addition to several infectious diseases, Alzheimer’s, diabetes, atherosclerosis and other major disorders are now attributed, at least in part, to membrane traffic dysfunction.
The meeting will bridge basic to molecular and cellular aspects of cell membrane traffic in health and disease.

 Invited Speakers:

Antonella de Matteis – Telethon Institute of Genetics and Medicine, Naples, Italy.
Thomas Braulke – Dept. of Biochemistry, Childrens Hospital, Bldg. N27, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
Winchil Vaz –Chemistry Department, University of Coimbra
José Leal –IGC, Portugal
Duarte Barral –CEDOC, Faculty of Medicine, University of Lisbon
Henrique Girão –IBILI, University of Coimbra
Otília Vieira –CNC, University of Coimbra
Marisa Rego – CNC, University of Coimbra
Ângela Inácio – CNC, University of Coimbra


Monday, 18th February 2013

9h-9.15h: Structure of the course; Introduction of students and lecturers
9.15h-10.30h: Endocytosis and the endocytic pathway – Otília Vieira
11h-12.15h: What model membranes can teach us about membrane traffic – Winchil Vaz
12.30h: Lunch
14h-15.15h: Phagocytosis and Pathogens – Otília Vieira
15.30h-16.45h: Paper presentations by students
17.00h-17.30h: Short talk: Plasma membrane repair during Mycobacterium tuberculosis Infection – Marisa Rego

Tuesday, 19th February 2013

9h-10.15h: Exocytosis and the secretory pathways – Duarte Barral
10.30h-11.45h: Ubiquitin signaling in intracellular trafficking – Henrique Girão
12.00h: Lunch
14h-15.15h: Ciliary trafficking and ciliopathies – Duarte Barral
15:30h-16.00h: Short talk: How membranes can help in the design of small molecules to tackle Sexually Transmitted Infections – Ângela Inácio
16.15h-17.30h: Paper presentations by students

Wednesday, 20th February 2013

9h-10.15h: Cross-talk between cholesterol and lysosomes – Thomas Braulke
10.30h-11.45h: Towards the chemical etiology of atherogenesis – the role of cholesteryl-hemiesters – Winchil Vaz
12.00h: Lunch with students and speakers
14h-15.15h: What we can learn from mendelian disorders of membrane trafficking – Antonella de Matteis

16.00-1700h: Missorting of lysosomal proteins in neurodegeneration – CNC Seminar – Thomas Braulke

Thursday, 21st February 2013

9h-10.15h: The phosphoinositides and the Golgi complex – Antonella de Matteis
10.30h-11.45h: The evolution of intracellular parasitism and the development of new antimicrobials – José Leal
12.00h: Lunch
14h-15.15h: Centrosomes, evolution and the development of prognostic markers for cancer progression – José Leal
15.30h-16.45h: Paper presentations by students

Friday, 22nd February 2013

9h-10.15h: Deregulation of Cx43 trafficking in heart disease – Henrique Girão.
10.30h–11.45h: Paper presentations by students
12.00h: Lunch
14.00:17.00h: Paper presentations by students

Student Assignments:The students are organized in groups and to each group is assigned one original papers. The group will present the paper, as well as their critical opinion on the major contribution of the paper, and its relevance to the field. The group is also expected to suggest a follow-up strategy for the project.

Background reading:

1. Ole Mouritsen, “Life as a Matter of Fat”, Springer Verlag, 2005; and W.L.C. Vaz, “Lipid Bilayers: Properties”, In: Wiley Encyclopedia of Chemical Biology; DOI: 10.1002/9780470048672.wecb281, John Wiley, 2008

2. O.V. Vieira, D.O. Hartmann, C.M. Cardoso, D. Oberdoerfer, M. Baptista, M. Santos, L. Almeida, J. Ramalho-Santos, W.L.C. Vaz (2008). Surfactants as microbicides and contraceptive agents: a systematic in vitro study. PloS ONE 3(8):e2913

3. L.M.B.B. Estronca, J. Silva, J. Sampaio, A. Shevchenko, P. Verkade, W.L.C. Vaz, O.V.Vieira (2012). Native low density lipoproteins enriched in a cholesteryl hemiester induce “foam cell” formation in macrophages: implications for atherogenesis. PLoS One. 7(4):e34822

4. K. Kollmann, M. Damme, S. Markmann, W. Morelle, M. Schweizer, I. Hermans-Borgmeyer, A.K. Rochert, S. Pohl, T. Lubke, J.-C Michalsky, R. kakela, S. U. Walkley and T. Braulke (2012). Lysosomal dysfunction causes neurodegeneration in mucolipidosis II Knock-in mice. Brain 135, 2661-2675

5. T. Braulke and J.S. Bonifacino (2009). Sorting of Lysosomal Proteins. BBA 1793, 605-614.

6. Kirkness E et al. (2010) Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. PNAS 107, 12168–12173.

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