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Chondrocyte Senescence: Implications in Osteoarthritis and Cartilage Tissue Engineering
March 5 - 7
Alexandrina Mendes
Chondrocyte senescence:
implications in osteoarthritis and cartilage tissue engineering

Course schedule

Monday, March 5th:

9h30-9h45: Introduction to the course: objectives, programme and students’ evaluation

9h45-10h45: Cartilage composition and chondrocyte biology: general overview
    Alexandrina Ferreira Mendes

11h-12h: Cellular and molecular mechanisms of chondrocyte senescence and OA: inflammation     Alexandrina Ferreira Mendes

Tuesday, March 6th:

9h30-10h30: Cellular and molecular mechanisms of chondrocyte senescence and OA:     mitochondrial dysfunction
    Francisco Blanco

11h-12h: Proteomics in OA: challenges and applications
    Francisco Blanco

14h30-15h30: Mesenchymal stem cells and gene therapy in cartilage repair
    Francisco Blanco

15h45-17h: Preparation of paper presentations

Wednesday, March 7th:

9h15-13h: Students’ evaluation: presentation and discussion of selected papers (10 min     presentation + 10 min discussion)

14h15-15h15: Open seminar: Metabolic osteoarthritis – Francisco Blanco

Students’ assignments and distribution:

Group 1: Rui Providência, Tânia Marisa Perestrelo
Brandl A, Hartmann A, Bechmann V, Graf B, Nerlich M, Angele P. Oxidative stress induces senescence in chondrocytes. J Orthop Res. 2011; 29: 1114-1120.

Group 2: Ana Teresa Rufino, António Carvalho Silva , Joana Ribeiro Guedes
Loeser RF, Olex A, McNulty MA, Carlson CS, Callahan M, Ferguson C, Chou J, Leng X, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. (in press)

Group 3: Catarina Praça Almeida, Michela Comune, Sofia Constantino Romano
Dvir-Ginzberg M, Gagarina V, Lee EJ, Booth R, Gabay O, Hall DJ. TNFα-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis Rheum, (in press)

Group 4: André Filipe Soares , Dominique Moreira Fernandes, Vera Francisco
Rego-Perez I, Fernandez-Moreno M, Fernandez-Lopez C,Arenas J, Blanco FJ. Mitochondrial DNA haplogroups: role in the prevalence and severity of knee osteoarthritis. Arthritis Rheum. 2008; 58: 2387-96.

Group 5: Ana Patrícia Marques, João Pedro Moreira de Oliveira
Fernandez-Puente P, et al. Identification of a panel of novel serum osteoarthritis biomarkers. J Proteome Res. 2011; 10: 5095-101.

Group 6: João Ribas Almeida, Madalena A. Ribeiro, Mariline Mendes Silva
Hermida-Gomez T, Fuentes-Boquete I, Gimeno-Longas MJ, Muiños-Lopez E, Diaz-Prado S, de Toro FJ, Blanco FJ. Bone Marrow Cells Immunomagnetically Selected For CD271+ Antigen Promote In Vitro the Repair of Articular Cartilage Defects. Tissue Engineering Part A. 2011; 17: 1169-79.

Group 7: Marcelo José Marques Correia, Pedro Centeio Ferraz Gameiro, Sara Monteiro Lopes,
Im GI, Kim HJ. Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells. Osteoarthritis Cartilage. 2011; 19: 449-57.

Evaluation criteria:

Integration with knowledge in the area
Critical interpretation of results and discussion
Implications (basic and/or clinical) and future directions for research
Clarity and objectivity


Francisco Javier Blanco, Research Director
CIBER-BBN, Centro de Investigación Biomédica of the Centro Hospitalario Universitário A Coruña
INIBIC - Instituto de Investigación Biomédica de A Coruña,
A Coruña, Spain

Alexandrina Ferreira Mendes – organizer
Centre for Neuroscience and Cell Biology and
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal
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