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MIT – Drug Development
 
January 16 - 27
João Nuno Moreira (jmoreira@ff.uc.pt), Luís Almeida, Sérgio Simões
MIT-PT PROGRAMME 2011/2012
PRINCIPLES AND PRACTICE IN DRUG DEVELOPMENT - ELECTIVE COURSE
Center for Neuroscience and Cell Biology (CNC) - University of Coimbra

January 16-27, 2012

João Nuno Moreira, Luís Pereira de Almeida, Sérgio Simões, Stan Finkelstein

CNC Auditorium





January 16
09.30 h - Introduction to the course
João Nuno Moreira - PhD (CNC and Faculty of Pharmacy, University of Coimbra)
Luís Pereira de Almeida - PhD (CNC and Faculty of Pharmacy, University of Coimbra)
Sérgio Simões - PhD (CNC and Faculty of Pharmacy, University of Coimbra)

10.00 h - BIOALVO – A story of entrepreneurial learning in the drug discovery path
Helena Vieira - PhD (CEO BIOALVO SA)

14.00 h - Visit to Biocant Park – Innovation Center in Biotechnology


January 17
10.00 h - Regulatory Affairs – the european perspective
Rogério Gaspar - PhD (iMed.UL and Faculty of Pharmacy, University of Lisbon)

16.00 h - The Pharmaceutical Industry and the Drug Development Process
Stan N. Finkelstein - MD, PhD (Senior Research Scientist in the MIT Engineering Systems Division and Associate Professor of Medicine, Harvard Medical School)


January 18
10.00 h - Modeling chemistry and biology in drug discovery
Nuno Palma - PhD (BIAL, Indústria Farmacêutica, Portugal)

11.30 h - Clinical development of new chemical entities
Nélson Lopes - PharmD, MD (BIAL, Indústria Farmacêutica, Portugal)

14.30 h - Development of small molecule inhibitors for treatment of CNS disorders
Laszlo Kiss - PhD (BIAL, Indústria Farmacêutica, Portugal)

16.00 h - Pharmacology and toxicology of new chemical entities
Lyndon C. Wright - PhD (BIAL, Indústria Farmacêutica, Portugal)


January 19
10.00 h - Some issues in drug development: discussion of case studies
Miguel Prazeres - PhD (Instituto Superior Técnico, Technical University of Lisbon)

16.00 h - Technology transfer – the perspective from MIT
Aaron Schwartz - (Licencing officer at the MIT TLO)


January 20
10.00 h - The Pharmaceutical Industry in the 21st century
Peter Villax - Member of the board Hovione

16.00 h - Biomanufacturing
Anthony J. Sinskey - PhD (Professor of Biology at MIT)


January 23
10 h - Photodinamic therapy in oncology
 Luís Almeida - PhD (Luzitin, SA)  - PDF

16 h - Post marketing drug safety
Judy Maro - PhD student in the MIT Engineering Systems Division

January 24
9.30 h - Nanotechnology for drug and gene targeting and the impact on drug development
Sérgio Simões - PhD
João Nuno Moreira - PhD
Luís Pereira de Almeida - PhD

14:30h - Bluepharma Pharmaceutical Industry SA: from development of generics to innovative research - site visit

January 25
9 h - Students presentations

January 26
Pharma Industry Symposium, Lisbon (MIT-Portugal/Hovione)

January 27
9.30 h - Hovione - site visit


Documents

Introduction_JN Moreira.pdf

Rogerio Gaspar_2012_01_17_MIT_Portugal_CNC_final.pdf

MIT_BEB class 12_João Nuno Moreira.pdf

BIAL
ABB_2000_384_361.pdf

AlmeidaL_DrugsR&D_4_207_2003.pdf

AlmeidaL_JClinicalPharmacol_43_1350_2003.pdf

AlmeidaL_JClinNeuropharmacol_27_17_2004.pdf

Biochemical_Pharmacology_2009_78_1043.pdf

COMT_book_chapter.pdf

DMD_2003_31_250.pdf

EJP_2003_460_163.pdf

FerreiraJJ_ClinNeuropharmacology_31_2_2008.pdf

FerreiraJJ_CNSNeurosc&Ther_16_337_2010.pdf


J_Med_Chem_2010_53_8_3396_3411.pdf

JMedChem_2005_48_8070.pdf

Kiss_LE_JMedChem_53(8)_3396_2010.pdf

LearmonthDA_JMedChem_45_685_2002.pdf

LoureiroAI_DrugMetabDispos_34_1856_2006.pdf

MolPharmacol_2002_62_795.pdf

PEP_2001_23_106.pdf

WrightLC_DrugMetabolLetters_4_149_2010.pdf

Apresentação NL - CoimbraMIT2012.pdf


Bioinformatics
Bissantz, Kuhn, Stahl - 2010 - Journal of medicinal chemistry.pdf

Chen et al. - 2001 - Journal of Medicinal Chemistry.pdf

Cruciani, Pastor, Guba - 2000 - European journal of pharmaceutical sciences official journal of the European

Gasteiger - 2003 - Mini reviews in medicinal chemistry.pdf

Güner, Clement, Kurogi - 2004 - Current medicinal chemistry.pdf

Loving, Alberts, Sherman - 2010 - Current Topics in Medicinal Chemistry.pdf

Miller - Unknown - Small.pdf

Nicholls et al. - 2010 - Journal of Medicinal Chemistry.pdf

Oprea et al. - 2002 - Molecules.pdf

Smith et al. - 2003 - Journal of medicinal chemistry.pdf

van de Waterbeemd, Gifford - 2003 - Nature reviews. Drug discovery.pdf

Woltosz - 2011 - Journal of Computer-Aided Molecular Design.pdf


Hovione
The pharmaceutical industry in the 21st century.pdf


Bioalvo
Drug discovery basics

hit-to-lead_discovery_2006.pdf

hit-to-lead_odissey_2004.pdf

new CNS therapies_2011.pdf

SmallHistoryDD.pdf

Apresentacao_HV_BIOALVO_MIT_PT2012.pdf

DD2012_update.pdf

Luzitin
PDT in cancer - update - June 2011.pdf


MIT
Edwards-Value-Creation.pdf

Finkelstein-Pharma-Industry-Today.pdf

Kishimoto-Contaminated.pdf

Laurencin-The-FDA.pdf

Leiden-Canaries.pdf

Livingston-Toward-Mechanism.pdf

Radley-Off-Label.pdf

Schiff-Biotechnology.pdf

Schwartz-Heparin.pdf

Zivin-Understanding.pdf

Posner-First-Admin-Guide-2000.pdf

Rang-Chapter-1-Development.pdf

Rang-Chapter-2-Nature-Disease.pdf

Rang-Chapter-3-Therapeutic-Modal.pdf

Walsh-Chapter1-Pharmaceuticals.pdf

Walsh-Chapter2-Drug-Develop.pdf


Distribuição por quartos_meeting CNC Hovione Sheet1.pdf

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