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Neuroendocrinology & Neuromodulation
 
December 5 - 9
Paula Moreira (pismoreira@gmail.com), Ana Duarte, Rosa Resende
Neuroendocrinology and Neuromodulation Advanced Course

Coordinators: Ana I. Duarte, Paula I. Moreira, Rosa Resende


Programme

Monday, December 5th, 2011
9h30 - Introduction to the course (A. Duarte, P. Moreira, R. Resende)
10h-11h - Diabetes mellitus: more than a peripheral metabolic disease (A. Duarte)
Coffee break (15 min)
11h15-12h15 - Diabetes and Alzheimers disease: common denominators (P. Moreira)
12h15-14h – Lunch time
14h-15h – Microvascular complications in diabetes and Alzheimers disease (R. Fernandes)

Tuesday, December 6th
9h30-10h30 - Neuropeptide Y: more than food intake regulator? (C. Cavadas)
Coffee break (15 min)
10h45-11h45 - Leptin regulation of neuronal excitability and cognitive function (J. Harvey)
11h45-12h45 – Leptin: the missing link in Alzheimers disease? (J. Harvey)
12h45-14h30 – Lunch
14h30 – Preparation of students presentations


Wednesday, December 7th
10h-11h – The extra-hypothalamic functions of ghrelin. Relevance for therapeutic intervention in Alzheimers disease (R. Resende)
Coffee break (15 min)
11h15-12h15 - Endocannabinoids and the brain (A. Kofalvi)
12h15-13h - Impact of caffeine and interest in targetting adenosine A2A receptors in the control of memory dysfunction (R. Cunha)
13h-14h30 – Lunch
14h30 - Students presentations (Groups 1, 2 & 6)

Thursday, December 8th
9h30-10h30 - Periphery-CNS crosstalk: when insulin challenges an old paradigm (A. Duarte)
Coffee break (15 min)
10h45-11h45 – Circulating IGF-I and the brain. I. Mechanisms of entrance of serum IGF-I into the brain (I. Torres-Aleman)
11h45-12h45 – Circulating IGF-I and the brain. II. Role of serum IGF-I in the impact of life-style on brain aging and associated diseases. (I. Torres-Aleman)
12h45-14h30 – Lunch
14h30 - Students presentations (Groups 3, 4 & 5)

Friday, December 9th
9h30-10h30 - Effects of estrogen in the brain: Is it a neuroprotective agent? (P. Moreira)
Coffee break (15 min)
10h45-12h – Short-presentations by CNC students (15 min/presentation)
- Fluoxetine promotes the proliferation of hypothalamic neuroprogenitor cells and modifies the expression of neuropeptides that regulate appetite (L. Sousa-Ferreira)
-    Hyperglycemia-mediated induction of apoptosis and autophagy in cortical neurons (R. Santos)
- Insulin and Huntingtons disease: the truth behind the scene (T. Rosenstock)
-    Adenosine-trophic factors crosstalk in microglia: Unravelling neuroprotective mechanisms of adenosine receptors modulation (C. Gomes)
12h - Lunch
16h-17h – Seminar: Neurobiology of IGF-I in health and disease (I. Torres-Aleman)


Students Assignments    

As evaluation, each group of students (2 or 3/group) will have to present a critical analysis of a paper. In this presentation, students will have to play the role as if this was their own paper and have to defend it over a jury. Additionally, students will be asked to write their analysis taking into account the “jurys” comments and to provide the follow-up of this study, in English, Arial 11pt, normal spacing and with a maximum of 2 pages (excluding references). This follow-up proposal may include:
-    Title
-     Rationale and Aim
-    Task(s) (including expected results and methodology)
-    References

The proposal should be sent to Paula Moreira (pismoreira@gmail.pt) by December 9th, 2011.

Evaluation criteria are:     
- Scientific quality;
-    Novelty;
-    Feasibility;
-    Relevance (to the area of research).

GROUPS
Group 1: Ana Patricia Marques, André Filipe Soares, António Carvalho Silva -
Group 2: Catarina Praça Almeida, Dominique Moreira Fernandes, Joana Ribeiro Guedes -
Group 3: João Ribas Almeida, Mariline Mendes Silva, Ana Maria Silva -
Group 4: Sara Monteiro Lopes, Sofia Constantino Romano, Natalie Rens -
Group 5: Tânia Marisa Perestrelo, Marcelo José Marques Correia, Nuno Machado -
Group 6: Tiago Santos, Rodolfo Águas -


Lecturers
Ana I. Duarte (Postdoctoral Fellow @ Center for Neuroscience and Cell Biology, Molecular Mechanisms of Disease Group, University of Coimbra, Coimbra, Portugal)

Attila Köfalvi (Assistant Researcher @ Center for Neuroscience and Cell Biology, Neuromodulation & Metabolism Lab, University of Coimbra, Coimbra, Portugal)

Catarina Gomes (Postdoctoral Fellow @ Center for Neuroscience and Cell Biology, Neuromodulation Group, University of Coimbra, Coimbra, Portugal)

Cláudia Cavadas (Assistant Professor @ Faculty of Pharmacy and Center for Neuroscience and Cell Biology, Neuroendocrinology & Neurogenesis Group, and Director of Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal)

Ignacio Torres-Alemán (Principal Investigator @ Departamento de Neurobiología Funcional y de Sistemas, Laboratorio de Neuroendocrinologia, Instituto Cajal, CSIC, Madrid, Spain)

Jenny Harvey (Wellcome Senior Lecturer @ Centre for Neuroscience, Division of Medical Sciences College of Medicine, Dentistry & Nursing 
Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland)

Lígia Sousa-Ferreira (PhD student @ Center for Neuroscience and Cell Biology, Neuroendocrinology & Neurogenesis Group, University of Coimbra, Coimbra, Portugal)

Paula I. Moreira (Teaching Assistant @ Faculty of Medicine and Center for Neuroscience and Cell Biology, Molecular Mechanisms of Disease Group, University of Coimbra, Coimbra, Portugal)

Renato Santos (PhD student @ Center for Neuroscience and Cell Biology, Molecular Mechanisms of Disease Group, University of Coimbra, Coimbra, Portugal)

Rodrigo Cunha (Associate Professor @ Faculty of Medicine and Center for Neuroscience and Cell Biology, Neuromodulation Group, University of Coimbra, Coimbra, Portugal)

Rosa Fernandes (Researcher @ Institute for Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Portugal)

Rosa Resende (Postdoctoral Fellow @ Center for Neuroscience and Cell Biology, Molecular Mechanisms of Disease Group, University of Coimbra, Coimbra, Portugal)

Tatiana Rosenstock (Postdoctoral Fellow @ Center for Neuroscience and Cell Biology, Mitochondrial Dysfunction and Signaling in Neurodegeneration Group, University of Coimbra, Coimbra, Portugal)
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