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Metabolic Remodeling in Cancer
February 6 - 10
Paulo Oliveira, John Jones
Advanced Course “Metabolic Remodeling in Cancer”
(February 6-10, 2012)
Registration for outside students: January 15, 2012


John Jones, Ph.D.              Center for Neuroscience and Cell Biology
Paulo Oliveira, Ph.D.          Center for Neuroscience and Cell Biology

Invited External Speakers:

Frederick Domann, Ph.D.Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

Walter Gall, Ph.D. Head of Diagnostic Development, Metabolon, Research Triangle Park, Durham, NC 27713, USA

Valdemar Maximo, Ph.D. University of Porto Institute of Molecular Pathology and Immunology, Portugal

Monday (06-02-2011)
14:00-14:45    Valdemar Maximo, “The metabolism of tumor cells”
14:45-15:30    Paulo Oliveira, “Mitochondrial anti-apoptotic adaptations in tumor cells”
15:30-16:00  Ignacio Vega-Naredo, Marie Curie Pos-Doc fellow “Changes in mitochondrial physiology during differentiation of P19 embryonic stem cells: Relevance for reducing resistance to cell death”

Tuesday (07-02-2011)
9:15-10:15    Rui Carvalho, “Alterations in glycolysis and TCA cycle kinetics during cell differentiation: a multinuclear NMR approach”
10:30-11:30    John Jones, “Enhancing metabonomics with stable isotope tracers”
11:30-12:00    Ludgero Tavares, PhD Student “Changes in mitochondrial physiology during differentiation of P19 embryonic stem cells: alteration from glycolytic to aerobic metabolism”
14:00 – 16:00    Presentations by PhD Students and Evaluation

Wednesday (08-02-2011)
9:15-10:15    Frederick Domann, “Theories on the origins of cancer: Toward a unifying theory”
10:30-11:30    Frederick Domann,“ Epigenetic control of gene expression in normal and cancer cells”
11:30-12:00    Teresa Serafim, Pos-doc fellow “Natural-based compounds that target cancer cell mitochondria”
14:00-16:00    Presentations by PhD Students and Evaluation

Thursday (09-02-2011)
9:15-10:15    Walter Gall, “Metabolomics technology and commercialization of novel diagnostics”
10:30-11:30   Walter Gall, “Clinical applications in metabolomics in metabolic disease and cancer”
15:00-16:00  Ines Barbosa, Ph.D. student “Role of mitochondrial TRAP-1 and PINK in cancer tolerance to chemotherapeutics”
16:00-17:00  Frederick Domann (CNC Seminar), “Metabolic epigenetics and the progression of cancer”

Friday (10-02-2011)
9:15-10:15 Valdemar Maximo, “Genetic causes for the Warburg Effect of tumour cells –insights from Hürthle cell thyroid tumours and inherited neoplastic syndromes”
10:15-10:45 Vilma Sardão, Pos-Doc fellow “And Now for Something Completely Different: The Reverse Warburg Effect”
10:45-12:30 Presentations by PhD Students and Evaluation
12:30-14:00 “Meet the experts” and “Free Beer Tasting”

Student Groups

I – Dominique Fernandes/Tânia Perestrelo
II – Ana Maria Silva/Sofia Romano/Marta Pereira
III – Lorenzo Marconi/João Almeida
IV – Marcelo Correia/André Soares
V – Ana Marques/Joana Guedes
VI – António Silva/Sara Lopes
VII – Catarina Almeida/Miguel Lino
VIII - Mariline Silva/Kátia Mesquita

Group I      (paper 1)
Group II     (paper 2)
Group III    (paper 3)
Group IV    (paper 4)
Group V     (paper 5)
Group VI    (paper 6)
Group VII   (paper 7)
Group VIII  (paper 8)

Paper 1: Fitzgerald MP, Gourronc F, Teoh ML, Provenzano MJ, Case AJ, Martin JA, Domann FE. Human Chondrosarcoma Cells Acquire an Epithelial-Like Gene Expression Pattern via an Epigenetic Switch: Evidence for Mesenchymal-Epithelial Transition during Sarcomagenesis. Sarcoma. 2011;2011:598218.

Paper 2: Place TL, Fitzgerald MP, Venkataraman S, Vorrink SU, Case AJ, Teoh ML, Domann FE. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS One. 2011 Jan 28;6(1):e14617.

Paper 3: Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, and Spitz DR. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2-* and H2O2. Free Radic Biol Med, in press, Oct 2011.

Paper 4: Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simões M. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer. 2005 May 23;92(10):1892-8.

Paper 5: Lima J, Feijão T, Ferreira da Silva A, Pereira-Castro I, Fernandez-Ballester G, Máximo V, Herrero A, Serrano L, Sobrinho-Simões M, Garcia-Rostan G. High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations. J Clin Endocrinol Metab. 2007 Dec;92(12):4853-64.

Paper 6: Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011 Aug 31;477(7362):54-60.

Paper 7: Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4.

Paper 8: Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ, Ryals JA, Milburn MV, Nannipieri M, Camastra S, Natali A, Ferrannini E; RISC Study Group. Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One. 2010 May 28;5(5):e10883.

Papers 1-3 will be presented on Tuesday (7-02); 4-6 on Wednesday (8-02) and 7-8 on Friday (10-02).

Evaluation of each PhD student will consist of multiple points, namely:

i) Assiduity –    15 min intervals for coffee break in morning session and two hours for lunch; these periods need to be fully respected and no delays in appearance in each session will be allowed – doors will be closed and no appearance on time used in evaluation.

ii) Participation in Sessions – in order to motivate students to question each speaker, “meaningful” questions should be addressed by PhD students; thus a full attention to the presentations will be mandatory – for this to happen no usage of portable computers and mobile phones will be allowed in the room, except WHEN AUTHORIZED to take notes; this will also be the case during the sessions of student presentations; you should question your colleagues and should not wait for all questioning to be made by the evaluators.

iii) Quality of Presentation  (maximum duration of 30 min with questions) – within this topic we can consider several aspects, namely clarity and critical attitude towards the methodology and scientific results reported in the manuscript. A “bonus” will require pointing out flaws in the work and ways to overcome such criticism.

Emails of non-BEB students:

Lorenzo Marconi - lorenzooliveiramarconi@gmail.com

Miguel Lino - miguel.m.lino@gmail.com
Ana Maria Silva - anamariapsilva@gmail.com   
Katia Mesquita - mesquita.al0602@gmail.com
Marta Pereira - marta.dot.isabel@gmail.com

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