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Neurodegenerative disorders: From molecules to clinics and beyond
 
October 24 - 28
Core CNC Neuroscience Courses, Offered to the European Neuroscience Campus (ENC)

Ana Cristina Rego, Paula Agostinho, Inês Araújo, Cláudia Pereira, Luís Pereira de Almeida

acrego@cnc.uc.pt
Course Schedule - “Neurodegenerative diseases: From molecules to clinics and beyond”
October 24-28, 2011

Monday (Oct 24)

9:30-10:00- Presentation of students and speakers. Presentation of students assignments.

10:00-10:30- Introduction to neurodegenerative disorders
Ana Cristina Rego

10:30-11:30- Proteostasis
Cláudia Pereira

11:30-11:45 Break

11:45-12:30- Neuroinflammation
Paula Agostinho

Free afternoon – students assignments


Tuesday (Oct 25)

9:30-10:30- Translational research in Alzheimers disease.
Inês Baldeiras

10:30-11:15- Endoplasmic reticulum stress response in Alzheimers disease
Cláudia Pereira

11:15-11:30- Break

11:30-12:30- Metabolic dysfunction and AD
Paula Moreira

12:30-14:30- Lunch

14:30-15:00- Amyloid-beta and prion peptides neurotoxicity
Paula Agostinho

15:00-16:00- Clinical aspects of Alzheimers disease. Clinical trials
 Isabel Santana


Wednesday (Oct 26)

9:30-10:30- Introduction to Parkinsons disease
GDNF and Parkinsons disease
Emília Duarte

10:30-11:00 Break

11:00-12:00- Mitochondria key role in Parkinson disease
Sandra Morais Cardoso

12:00-14:30- Lunch

14:30-15:30- Deep brain stimulation: from the experience in Parkinsons disease to most recent indications and future developments
Rui Vaz

16:00-17:00
Seminar: “Cell transplantation in Parkinsons disease: from clinical trials to benchside”
Mariah Lelos


Thursday (Oct 27)

9:30-10:30- Introduction to polyglutamine disorders
Cell transplantation: a potential therapeutic strategy for Huntingtons disease?
Mariah Lelos

10:30-10:45- Break

10:45-11:30- Intracellular localization of polyglutamine-expanded proteins
Ana Luísa Carvalho

11:30-13:00- Mouse and worm models of Machado-Joseph disease: tools for therapy development.
Patrícia Maciel

13:00-14:30- Lunch

14:30-15:15- Clinical aspects of polyglutamine disorders
Cristina Januário

15:15-15:30- Break

15:30-16:00- IGF-1 and insulin pathway in Huntingtons disease
Ana Cristina Rego

16:00-16:30- Modelling and modifying Machado-Joseph disease 
Luís P. Almeida


Friday (Oct 28)

9:30-10:00- Multiple-choice examination

10:00-10:30- Break

10:30-12:30- Presentations (max. 30 min/group)

Group 1- Ana Patricia Marques, Mariline Mendes Silva, Ricardo Ferreira
Paper 1- Hübener J, Vauti F, Funke C, Wolburg H, Ye Y, Schmidt T, Wolburg-Buchholz K, Schmitt I, Gardyan A, Driessen S, Arnold HH, Nguyen HP, Riess O. (2011) N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation. Brain. 134:1925-42.

Group 2- André Filipe Soares, Marcelo Correia ; Tânia M. Perestrelo, Ana Isabel Santos
Paper 2- Wiley JC, Pettan-Brewer C, Ladiges WC. (2011) Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice. Aging Cell 10:418-28

Group 3- António Silva, Dominique Fernandes, Sofia Romano, Ana Sofia Lourenço
Paper 3- Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. (2011) CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimers disease mice. J Neurosci. 31:1355-65.

12:00-14:00- Lunch

14:00-15:00- Presentations (max. 30 min/group)

Group 4- Catarina P. Almeida , Joana R. Guedes, Daniel Santos
Paper 4- Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK.(2011) IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Hum Mol Genet. 2011 (in press)

Group 5- João R. Almeida, Sara M. Lopes, Vanessa Machado
Paper 5- Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O, Brundin P. (2008) Lewy bodies in grafted neurons in subjects with Parkinsons disease suggest host-to-graft disease propagation. Nat Med. 14:501-3.


Students Assignments and Distribution
The evaluation criteria will include:
-    Multiple choice examination (5 in 20)
-    Participation during the course (5 in 20)
-    Fictive projects (paper presentation, critical review of paper, proposal novelty, hypothesis-driven proposal, expected results) (10 in 20)


The students (Groups 1-5) will be asked to consider an assigned paper as representing a pivotal work and prepare a brief project stating what experiments would be important to do next. While briefly mentioning the paper findings, the students should concentrate on which directions the research would take.
Apart from presenting data selected from the paper, presentation of the project should have the following points:
-Title
-State of the Art (include some data from the assigned paper)
-Objectives 
-Tasks (maximum 3, including expected results and descriptions)
-Research Team

The fictive projects will be presented (30 min) and discussed (15 min) during Friday (14 October) morning (10:30-12:30) and afternoon (14:00-15:00).


Affiliations - Lecturers:

Mariah Lelos (LelosMJ@cardiff.ac.uk)
Brain Repair Group; School of Biosciences
Museum Avenue Cardiff University
Cardiff, UK

Rui Vaz (ruimcvaz@gmail.com)
Neurosurgery Service of S. João Hospital
Faculty of Medicine, University of Porto
Porto, Portugal

Patrícia Maciel (pmaciel@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho
Braga, Portugal

Inês Baldeiras (ines.baldeiras@sapo.pt)
Laboratory of Neurochemistry
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Cristina Januário (cristinajanuario@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Isabel Santana (isabeljsantana@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Emília Duarte (epduarte@cnc.uc.pt)
Center for Neuroscience and Cell Biology
Department of Life Sciences, University of Coimbra
Coimbra, Portugal

Ana Luísa Carvalho (alc@cnc.uc.pt)
Center for Neuroscience and Cell Biology
Department of Life Sciences, University of Coimbra
Coimbra, Portugal

Sandra M. Cardoso (scardoso@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Paula Isabel Moreira (pismoreira@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) – Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Cláudia MF Pereira (claudia.mf.pereira@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Inês Araújo (imaraujo@ualg.pt) – Organizer
Regenerative Medicine Program
Department of Biomedical Sciences and Medicine
University of Algarve
Faro,Portugal

Luís Pereira de Almeida (luispa@cnc.uc.pt; luispa@ci.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal

Paula Agostinho (pmgagostinho@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
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