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Excitotoxic Signaling
 
October 19 - 21
Core CNC Neuroscience Courses, Offered to the European Neuroscience Campus (ENC)

Armanda Santos, Carlos Duarte, Ana Cristina Rego

aesantos@ci.uc.pt

Ph.D. Programme in Experimental Biology and Biomedicine 2011/2012

Core CNC Neuroscience Courses, Offered to the European Neuroscience Campus (ENC)

EXCITOTOXIC SIGNALING GRADUATE COURSE
Center for Neuroscience and Cell Biology (CNC) - University of Coimbra
Coimbra, 19-21 October 2011


Local Coordinators:
Armanda Emanuela Santos (aesantos@ci.uc.pt)
Carlos Bandeira Duarte (cbduarte@ci.uc.pt)
Ana Cristina Rego (arego@fmed.uc.pt)



LECTURERS

Michael J. Courtney
Dept. of Neurobiology
A. I. Virtanen Institute
University of Kuopio
Kuopio FIN 70211, Finland
courtney@messi.uku.fi

Sofia Duque Santos
Glial Cell Biology Group
Institute for Molecular and
Cell Biology - IBMC
Porto, Portugal
sasantos@ibmc.up.pt

João Laranjinha
Center for Neuroscience and Cell biology
& Faculty of Pharmacy
University of Coimbra
Coimbra, Portugal
laranjin@ci.uc.pt

Margarida Caldeira
Center for Neuroscience and Cell Biology
University of Coimbra
Coimbra, Portugal
margaridavcaldeira@gmail.com

Armanda E. Santos
Center for Neuroscience and Cell Biology
& Faculty of Pharmacy
University of Coimbra
Coimbra, Portugal
aesantos@ci.uc.pt

Ana Cristina Rego
Center for Neuroscience and Cell Biology
& Faculty of Medicine
University of Coimbra
Coimbra, Portugal
arego@fmed.uc.pt

Carlos Bandeira Duarte
Center for Neuroscience and Cell Biology
& Dept. Life Sciences
University of Coimbra
Coimbra, Portugal
cbduarte@ci.uc.pt



COURSE SCHEDULE

Wednesday, October 19
10:00 – 11:00 Mechanisms of glutamate receptor mediated excitotoxic neuronal death: role of Ca2+ and calpain activation
Armanda Santos

11:30 – 12:30 Mitochondrial dysfunction in excitotoxicity
Ana Cristina Rego

14:15 – 15:15 Mechanisms of glutamate receptor mediated excitotoxic neuronal death: NMDA receptors and associated proteins in excitotoxicity
Michael Courtney

15:30 – 16:30 Excitotoxicity and the Ubiquitin Proteasome System
Margarida Caldeira


Thursday, October 20
10:00 – 11:00 Protein kinase signalling in excitotoxicity
Michael Courtney

11:30 – 12:30 Ca2+-permeable AMPA receptor-mediated excitotoxicity
Armanda Santos

14:15 – 15:15 The ischemic stroke pathology
Armanda Santos

CNC seminar
16:00 “Delineation of Neurodegenerative Signalling Pathways”
Michael J. Courtney


Friday, October 21
10:30 – 11:30 Brain ischemia: animal models, methods and assessment
Sofia Duque Santos

11:45 – 12:45 Nitric oxide dynamics in the brain via glutamate receptor activation
João Laranjinha


14:30
Students Assignments and Distribution

The students (Groups 1-4) will be asked to consider an assigned paper as representing a pivotal work and prepare a brief project stating what experiments would be important to do next. While briefly mentioning the papers findings, the students should concentrate on which directions the research should take. Presentation of the project should have the following items:

-    Title;
-    State of the Art (include some data from the assigned paper)
-    Objectives
-    Tasks (maximum 3, including expected results and descriptions)
-    Research team

The fictive projects will be presented (30 min) and discussed (15 min) during Friday Afternoon.

 
Group 1: Catarina Almeida, António Silva, João Almeida, Daniel Santos
Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward and Jochen H.M. Prehn (2010), “AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress induced apoptosis”, J Cell Biol 189: 83–94
Suppl.

Group 2:
Joana Guedes, Marcelo Correia, Ivan Salazar, Mariline Silva
Peter L. Peng, Xiafen Zhong, Weihong Tu, Mangala M. Soundarapandian, Peter Molner, Dongya Zhu, Lorraine Lau, Shuhong Liu, Fang Liu and YouMing Lu (2006), “ADAR2-Dependent RNA Editing of AMPA Receptor Subunit GluR2 Determines Vulnerability of Neurons in Forebrain Ischemia”, Neuron 49, 719–733.

Group 3: Ana Marques, André Soares, Ana Isabel Santos, Dominique Fernandes
Ruslan I. Stanika, Natalia B. Pivovarova, Christine A. Brantner, Charlotte A. Watts, Christine A. Winters and S. Brian Andrews1 (2009), “Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity”, PNAS 106: 9854-9.
Suppl.

Group 4: Tânia Perestrelo, Sara Lopes, Sofia Romano, Steve Carvalho
B.D. Butts, H.R. Hudson, D.A. Linseman, S.S. Le K.R. Ryan, R.J. Bouchard, and K.A. Heidenreich (2005), “Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors”, Mol. Cell. Neurosci. 30: 279 – 289.


BACKGROUND READING

- Kinga Szydlowska and Michael Tymianski (2010), “Calcium, ischemia and excitotoxicity”, Cell Calcium 47: 122–129;

- Giles E. Hardingham and Hilmar Bading (2010), “Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders”, Nat Rev Neurosci 11: 682–696;

- Ted Weita Lai, Woei-Cherng Shyu and Yu Tian Wang (2011), “Stroke intervention pathways: NMDA receptors and beyond”, Trends in Molecular Medicine 17: 266 – 275

- Claire R Weston and Roger J Davis (2007) “The JNK signal transduction pathway” Current Opinion in Cell Biology 19:142–149.

- Shin Kwak and John H Weiss (2006), “Calcium-permeable AMPA channels in neurodegenerative disease and ischemia” Current Opinion in Neurobiology 16:1–7.

- Alexei Degterev and Junying Yuan (2008), “Expansion and evolution of cell death programmes”, Nat Rev Mol Cell Biol  9: 378-390.

- Li Zhou, Fei Li, Hai-Bing Xu , Chun-Xia Luo , Hai-Yin Wu, Ming-Mei Zhu, Wei Lu, Xing Ji, Qi-Gang Zhou and Dong-Ya Zhu (2010) “Treatment of cerebral ischemia by disrupting ischemia induced interaction of nNOS with PSD-95” Nature Medicine 16: 1439-1443.

- Weihong Tu, Xin Xu, Lisheng Peng, Xiaofen Zhong, Wenfeng Zhang, Mangala M. Soundarapandian, Cherine Belal, Manqi Wang, Nali Jia, Wen Zhang, Frank Lew, Sic Lung Chan, Yanfang Chen and Youming Lu (2010), “DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke”, Cell 140, 222–234.

- Márcio S. Baptista, Carlos V. Melo, Mário Armelão, Dennis Herrmann, Diogo O. Pimentel, Graciano Leal, Margarida V. Caldeira, Ben A. Bahr, Mário Bengtson, Ramiro D. Almeida, Carlos B. Duarte (2010), “Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons”, PLoS ONE 5(4): e10139
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