About BEB
CNC Research
BEB in the Media
February 21 - 25
Responsible: João Nuno Moreira


Coordinator: João Nuno Moreira (CNC, FFUC)
Place: CNC Seminar Room/Anfiteatro de Farmacologia (Faculdade de Medicina da Universidade de Coimbra- Pólo I, 2º Andar)

Basic Topics:
1.    Signaling transduction in cancer
2.    Importance of  microenvironment in tumour development and in tumour treatment
3.    Tumour metabolism and tumour growth
4.    Epigenetics: epigenetic markers and the importance of epigenetics in tumour therapy
5.    Stem cells: contribution for tumourigenesis, involvement in chemoresistance, role in tumour therapy
6.    Cancer therapy: Targeted delivery with non-viral vectors


Monday (February 21st)
9:00-9:30 – Introduction

9:30-10:30 – Signal transduction aberrations in cancer
João Taborda Barata
Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon
10:30-10:45 – Break
10:45- 11:45-  "Novel" concepts in cancer signal transduction
João Taborda Barata
12:00-13:00 – Lunch
13:00-13:45 - Journal club (Group I: Ana Cristina Gregório and M.ª Joana Guimarães Pinto)
13:45-14:30 - Journal club (Group II: Ângela Valério Fernandes, Pedro Azeredo Gouveia and João Martins)
14:30-14:45 – Break
14:45-15:45 – Dll4/Notch signalling as potential therapeutic target in cancer
Alexandre Trindade
Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinária, Technical University of Lisbon
15:45-16:45 - Journal club (Group III: Carla M.ª Nunes Lopes and Rodrigo Luiz Santos)

Tuesday (February 22nd)

10:00-11:00 – Tumor targeting with non-viral vectors: challenges and opportunities
João Nuno Moreira
Group of Vectors and Gene Therapy, Center for Neuroscience and Cell Biology and Faculty of Pharmacy, University of Coimbra
11:00-12:00 –Journal club (Group IV: Carla Patrícia Paiva and Rui Manuel Benfeitas)

14:30-15:30- Tumor Angiogenesis: molecular and cellular mechanisms and clinical implications
Sérgio Dias
Angiogenesis Group, Portuguese Institute for Oncology, Lisbon EPE (CIPM/IPOLFG)
15:30-16:30- Journal club (Group V: Fátima Patrícia Martins and Sofia Marques Ribeiro)
Wednesday (February 23rd) 

10:00-11:00 – Epigenetic in tumors
        Carmen Jerónimo
Department of Genetics from the Portuguese Institute for Oncology, Porto and Institute of Biomedical Sciences Abel Salazar, University of Porto
11:00-12:00 – Journal club (Group VI: Joana Domingues Vindeirinho and Sonya Costa)

Thursday (February 24th) 

17:00-18:00 – Introduction of Tumor Stroma and Microenvironment.
        Raghu Kalluri
Harvard Medical School and Beth Israel Deaconess Medical Center

Friday  (February 25th)

10:00 – 11:00- Molecular changes and cellular effects associated with deregulation of cadherin in cancer
Raquel Seruca
Institute of Molecular Pathology and Immunology of the University of Porto.
11:00-11:15 – Break
11:15-12:15 – Breast Cancer Stem Cells: its importance in cancer biology
Joana Paredes
Institute of Molecular Pathology and Immunology of the University of Porto.
12:15-14:00 – Lunch
14:00-14:45– Journal club (Group VII: Joana Espírito Santo and Ana Catarina Ferreira)
15:00-16:00 – Tumor Microenvironment Controls the Rate of Cancer Progression and Metastasis
        Raghu Kalluri
Harvard Medical School and Beth Israel Deaconess Medical Center

Students Evaluation
Each group is assigned one review paper and one research paper. Students should perform an oral presentation and discussion of the research paper.


Figure1 support paer group V

Group I

Group II

Group III

Group IV

Group V

Group VI

Group VII

Quality and quantity control at the endoplasmic reticulum.2010

Support paper for groups I and II

Support paper for group III

Support paper for group IV

Support paper for group V

Support paper for group VI

Table 1support paper group V
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