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Mitochondrial Dynamics and Metabolic Diseases
 
February 14 - 18
Responsible: Anabela Rolo (anpiro@ci.uc.pt)
Mitochondrial Dynamics and Metabolic Diseases (14-17 February 2011)

Coordinators: Anabela Rolo (anpiro@ci.uc.pt), Carlos Palmeira (palmeira@ci.uc.pt)

Aim: This course  is intended to bring to discussion pathways responsible for mitochondrial dysfunction in metabolic diseases. Emphasis will be given to regulation of mitochondrial biogenesis and dynamics of the mitochondrial network, as well as to the therapeutic potential of sirtuin activation in obesity and type 2 diabetes.

Topics:
- Characteristic responses of mitochondria in metabolic diseases.
- The relationship between mitochondrial shape and function.
- Molecular mechanisms that control mitochondrial network.
- Sirtuins: Cell survival dictated by nutrient-sensitive mitochondrial NAD+ levels
- The role of sirtuins in metabolism and longevity
- Role played by mitochondrial dynamics proteins in mitochondrial dysfunction in obesity or in type 2 diabetes
- SIRT1 activators as therapeutics for the treatment of type 2 diabetes.

Course Schedule:

Monday (Feb 14)

9.30 Presentation
9.45 – 10.45 Longevity genes: regulators of metabolism, disease and the pace of aging (David Sinclair)
10.45 – 11.00 Break
11.00 – 12.00 Imaging techniques to assess mitochondrial function in live cells (Jorge Oliveira)

Tuesday (Feb 15)
9.45 – 10.45 How do longevity genes work and can we make use of them? (David Sinclair)
10.45 – 11.00 Break
11.00 – 12.00 Mitochondria and selective vulnerability in neurodegeneration (Jorge Oliveira)

14.00 – 17.30 Presentations/Discussions

Wednesday (Feb 16)
9.45 – 10.45 Induction of SIRT1-dependent mitochondrial biogenesis and metabolic dysregulation (Anabela Rolo)
10.45 – 11.00 Break
11.00 – 12.00 Mitochondrial dynamics in cell physiology and death (Silvia Campello)

14.00 – 17.30 Presentations/Discussions

Thursday (Feb 17)
10.30 – 11.30 Rescue from dysfunction: mitochondria and salvage strategies (Filipe Duarte)
11.30 – 12.00 Break
12.00 – 13.00 Exploring the role of mitochondrial dynamics in T cells : movement, AICD, and..
 (Silvia Campello)

Lecturers:
David A. Sinclair (Department of Pathology, Harvard Medical School, Boston, USA)
Jorge Oliveira (Faculty of Pharmacy, University of Porto)
Anabela Rolo (Center for Neurosciences and Cell Biology, University of Coimbra)
Silvia Campello (Department of Cell Physiology and Metabolism, University of Geneva, Switzerland)
Filipe Duarte (Center for Neurosciences and Cell Biology, University of Coimbra)

Evaluation:
Students will be paired and a paper will be assigned for presentation.  The presentation should focus on two aspects:
1 - Introduction to the main findings of the paper,
2 - Brief project indicating a hypothesis and experiments that would be important to do next.
Each group has 20 minutes for presentation, followed by 15 minutes of discussion, coordinated by fellow students that must be prepared to ask questions to the presenting group. Both presentation (clarity, keeping time, critical thinking, novelty, feasibility) and chairing (asking critical questions, keeping session in time) will be evaluated. Students will also have to hand in a summary of the project proposal.
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