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Adult Stem Cells: from basic biology to cell replacement therapies
 
January 31 - February 4
Responsible: Inês Araújo
PDBEB Advanced Course

Adult stem cells - from basic biology to cell replacement therapies

31st January – 4th February  2011

Coordinators: Inês Araújo &  Cláudia Cavadas



APPLICATION DEADLINE:  January 21, 2011 (2 vacancies left, first come first served)



Why this course?


Adult stem cells provide a more readily available source of cells with the ability to form new cells and tissues rather than embryonic stem cells. Its usage also poses less ethical issues than embryonic stem cells. On the other hand, these cells are less plastic. Nevertheless, adult stem cells are at the forefront of regenerative medicine and constitute a strong research pillar at the CNC. In this course, we will dissect this exciting area, bringing together CNC researchers with outside speakers to treat the students to the latest bench research and new clinical applications.

The course will take place in the 2nd floor auditorium


Monday, January 31
9.15 –10.30 – Course presentation – Cláudia Cavadas e Inês Araújo
9.30 – 10.30 - Inês Araújo : Adult versus embryonic stem cells
Break
11.00 – 12.00 – Cláudia Cavadas:  Where can we find adult stem cells?
Lunch
14.00 – 15.00 – Manuela Gomes : Adipose stem cells for regenerative medicine
15:00  - 16:00 – Snapshots of ongoing CNC projects:
Ligia Sousa-Ferreira –Neurogenesis in the hypothalamus: is it important?
Celia Aveleira: Using hypothalamic neurospheres -  what for?
Magda Santana: Stem cells in adult adrenal gland – or not?

Tuesday, February 1
9.30 – 10.30 – João Ramalho Santos: Testicular Stem Cells: Regenerative Medicine for half the Humanity?
Break
11.00 – 12.00 – Alexandra Marques: Exploring the potential of stem cells for bone and skin tissue engineering
Lunch
14:00-15:00 – Snapshots of ongoing CNC projects
Isabel Onofre – iPSCs and disease models
Ana Carvalho -  Retinal stem cells
 
Wednesday, February 2
9.30 – 10.30 – Liliana Bernardino: Neural stem cells
Break
11:00 -12.00  - Snapshots of ongoing CNC projects:
Bruno Carreira: Nitric oxide and neurogenesis
Inês Morte : Antiepileptic drugs and proliferation of subventricular zone cells.
Lunch
14.00 – 17.00 - Paper presentations and discussion: groups 1 to 6
 
Thursday, February 3
9.30 – 10.30 – Lino Ferreira – Stem cells for cardiovascular applications - a bioengineering approach
Break
11.00 – 12.00 – Ricardo Pardal: Physiology of the adult carotid body stem cell niche
Lunch
14.00 – 15.00 – Seminar -  Ricardo Pardal: Peripheral nervous system stem cells as a treatment for Parkinson disease
 Break
15.30 – 17.30 - Paper presentations and discussion: groups 7 to 11
 
Friday, February 4
11.00 – 12.00 – Paula Marques Alves: Integrating stem cell expansion, differentiation and cryopreservation in bioreactors
Lunch
14.00 – 15.30 – Discussion of hot topics.
Break
16.00 – 17.00 – Seminar – Paula Marques Alves: Stem cell for drug discovery and cell therapy: bioprocess challenges.


Speakers:


Inês Araújo - CNC, University of Coimbra

Cláudia Cavadas- CNC and Faculty of Pharmacy, University of Coimbra

Manuela Gomes - 3Bs Research Group, Department of Polymer Engineering, University of Minho and Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Caldas das Taipas (Guimarães)

Lígia Sousa-Ferreira - CNC and Faculty of Pharmacy, University of Coimbra
Célia Aveleira - CNC, University of Coimbra

Magda Santana -CNC and Faculty of Pharmacy, University of Coimbra

João Ramalho Santos- CNC and Department of Life Sciences of FCTUC, University of Coimbra

Alexandra Marques - 3Bs Research Group, Department of Polymer Engineering, University of Minho and Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Caldas das Taipas (Guimarães)

Isabel Onofre - CNC and Faculty of Pharmacy, University of Coimbra

Ana Carvalho - CNC and Faculty of Pharmacy, University of Coimbra

Liliana Bernardino - CNC, University of Coimbra

Bruno Carreira - CNC and Department of Life Sciences of FCTUC, University of Coimbra

Inês Morte - CNC and Department of Life Sciences of FCTUC, University of Coimbra

Lino Ferreira  - BIOCANT and CNC, University of Coimbra

Ricardo Pardal - Instituto de Biomedicina de Sevilla, Depto. de Fisiología Médica e Biofísica, Universidad de Sevilla

Paula Marques Alves - ITQB-UNL/IBET, Lisbon


Evaluation

Each group presents a paper and also chairs the discussion of another paper (see assignments below). The Chairing students will introduce the colleagues presenting each paper, and will moderate the Q&A session, and have to be prepared to ask questions to the presenting group.
 
Each group has 10 minutes to present the corresponding paper, followed by 10 minutes of discussion, coordinated by the chairing group. Both presentation (clarity, keeping time, critical thinking, outlook) and chairing (asking critical questions, keeping session in time) will be evaluated.

GROUPS

1 - Ana Cristina Gregório
 Gladys Caldeira
 Ricardo Romão Nazário Leão
(chaired by 11)
 
2 - Ângela Valério Fernandes
Catarina Ferreira
João Carlos Gomes Silva Ribeiro
(chaired by 10)

3 - Carla M.ª Nunes Lopes
Joana Neves
Miguel Ferreira
 (chaired by 9)

4 - Carla Patrícia Paiva
Mariana Botelho da Rocha
Paulo Santos
(chaired by 8)

5 - Fátima Patrícia Martins
Mariana Conceição
Ricardo Leitão
(chaired by 7)

6 - Joana Domingues Vindeirinho
Ana Sofia Lourenço
João Casalta Lopes
(chaired by 5)


7- M.ª Joana Guimarães Pinto
Ana Isabel Santos
Ana Luisa Fialho Amaral de Areia
(chaired by 6)

8 - Pedro Azeredo Gouveia
Joana Catarina Espírito Santo
(chaired by 4)

9 - Rodrigo Luiz Santos
Vanessa Machado
Marta Jordão
(chaired by 3)

10 - Rui Manuel Benfeitas
Sonya Costa
Sandra Rebelo
(chaired by 2)

11 - Sofia Marques Ribeiro
Rogério Teixeiras
(chaired by 1)

Papers

1 - Serra et al 2009

2 -Gotz et al 2009

3 - Hargus et al 2010

4 - Holst et al 2010

5 - Pierce et al 2010

6 - Polo et al 2010

7 - Snapyan et al 2009

8 - Sasagawa et al 2010

9 - Wernig et al 2010

10 - Conrad et al 2008

11-Carlotti et al 2010

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