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The Complex World of RNA: RNA Regulation in Neuronal Development, Function and Dysfunction
December 9 - 10
Ramiro de Almeida, Ana Luísa Carvalho, Luís Pereira de Almeida, Carlos B. Duarte
RNA regulation in neuronal development, function and dysfunction

Coimbra, December 9-10, 2010

PhD programme in experimental Biology and Biomedicine 2010/2011
Center for Neuroscience and Cell Biology, University of Coimbra
CNC Auditorium, 2nd floor, Faculty of Medicine (Polo I)

Course Coordinators:
Ramiro D. Almeida (ramirodalmeida@gmail.com)
Ana Luísa Carvalho (alc@cnc.uc.pt)
Luís Pereira de Almeida (luispa@ci.uc.pt)
Carlos B. Duarte (cbduarte@ci.uc.pt)

Maria Luz Montesinos
Dpto. de Fisiología Médica y Biofísica
Facultad de Medicina. Universidad de Sevilla

Ramiro D. Almeida
CNC, University of Coimbra
Coimbra, Portugal

Ulrich Hengst
Columbia University Medical Center
New York, USA

Ana Luísa Cardoso
CNC, University of Coimbra
Coimbra, Portugal

Ana Eulálio
International Center for Genetic Engineering and Biotechnology (ICGEB)
Trieste, Italy

Luís Pereira de Almeida
CNC & Faculty of Pharmacy
University of Coimbra
Coimbra, Portugal

Manuel Santos
University of Aveiro, Portugal

Course schedule

Thursday, December 9
9:00-9:15h: Introduction and general notes
Ramiro D Almeida
9:15-10:15h: Non-coding DNA: not just junk after all
Ana Eulálio
10:15-10:45h: Break
10:45-12:00h: Mechanisms of gene silencing by miRNAs
Ana Eulálio
12:00-12:30h: miRNAs in the context of the brain immune response
Ana Luísa Cardoso
12:30-14:00h: Lunch break
14:00-15:00h: The role of tRNA processing and tRNA function on protein aggregation and neurodegeneration
Manuel Santos
15:00-16:00h: RNA interference as a therapeutic strategy in neurodegenerative diseases
Luís P Almeida
16:00-16:30h: Break
16:30-17:30h: Introduction to local translation in neurons
Ramiro D Almeida
17:30-18:30h: Role of local translation in axon development
Ulrich Hengst

Friday, December 10
9:00-10:00h: Function and regulation of local dendritic translation
Maria Luz Montesinos
10:00-10:30h: Break
10:30-11:30h: Control of axon growth and collapse through local protein production and degradation
Ulrich Hengst
11:30-12:30h: RNA transport and localized protein synthesis in neurodevelopmental disorders
Maria Luz Montesinos
12:30-14:30h: Lunch break
14:30h: Seminar by Ulrich Hengst
“Intra-axonal protein synthesis in neurodegenerative disorders”
16h: Seminar by Maria Luz Montesinos
“Deciphering the role of local translation in Trisomy 21 mental retardation”

Student’s Assignments
As an evaluation, students (groups of 4) will be asked to write a grant proposal. The starting point will be an assigned paper. The proposal should be written in English, Arial 11pt only, normal spacing and with a maximum of 3 pages (excluding references).
The final grant proposal should include the following:
- Title
- State of the Art
- Tasks (maximum 3 pages; should include expected results and methodology)
- References
The proposal should be sent to Ramiro Almeida (ramirodalmeida@gmail.com) by January 9th, 2011
The evaluation criteria are the following:
- Scientific quality
- Novelty
- Feasibility
- Relevance (to the area of research)

Group 1: Ana Gregório, Rui Benfeitas, Joana Pedro, Marta Jordão – Sebeo et al. - Sebeo et al.II
Group 2: Ângela Fernandes, Sofia Ribeiro, Magda Carvalho, Paulo Santos - Lee et al.
Group 3: Carla Lopes, Sonya Costa, Mª Inês Coelho, Ricardo Leitão – Napoli et al.
Group 4: Graceano Leal, Ana Carvalho, Mariana Conceição, Dominique Fernandes – Chiaruttini et al.
Group 5: Fátima Martins, Ana Serralheiro, Márcio Rodrigues, Joana Neves – Kota et al.
Group 6: Joana Vindeirinho, Daniela Gonçalves, Sandra Rebelo, Luís Leitão – Tcherkezian et al.
Group 7: Mª Joana Pinto, Rodrigo Santos, Carla Paiva – Wang et al.
Group 8: Pedro Gouveia, Joana Sousa, Gladys Caldeira – Andreassi et al.

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