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Cell Biology of Infection
 
November 8 - 12
Responsible: Otília Vieira
Cell Biology of Infection

Why a Course on Cell Biology of Infection:

Infection diseases are the second leading cause of death worldwilde. Two strategies are in use today to tackle infection diseases: antibiotic chemotherapy, targeting the microbe, and vaccination, aimed at stimulating the activity of the lymphocytes in the host. Despite these strategies infection diseases have been difficult to control, among other reasons, due to the problems of implementing an effective therapy, due to the emergence of drug-resistant bacteria, and due to the low efficacy of some current vaccines. Thus, effective treatment and cure for these diseases is essential to save lives and prevent transmission.

This course will be focused on the ways bacteria hijack our body´s cells and outwit our immune system. The importance of studying host-pathogen interactions to reveal the sophisticated bacterial strategies for co-opting and manipulating host cells to serve a bacterium´s needs will be addressed in detail.

Coordinator: Otília V. Vieira

Scientists with expertise in Cell Biology, Immunology and Microbiology that agreed to participate:

Victor Hsu- Associate Professor of Medicine, Harvard Medical School, Boston, MA
Heinz Remold- Senior Immunologist and Professor of Medicine, Harvard Medical School, Boston, MA
Rui Appelberg- Professor Catedrático, Instituto de Ciências Biomédicas de Abel Salazar-ICBAS (Department of Molecular Biology).
Wichil Vaz- Professor Catedrático, Chemistry Department, University of Coimbra.
Duarte Barral – Faculdade de Ciências Biomédicas, Lisbon, Portugal
João Gonçalves – Faculdade de Farmácia da universidade de Lisboa.

Preliminary Program

8-12 November

Monday, November 8
9:30 - Introduction
10:00 – Membrane heterogeneity: fact or fiction? (Winchil Vaz)
11:00 - Endocytic and biosynthetic pathways (Victor Hsu)
11:45 – Lunch break

13:45 – Biophysics of membrane structure in infection (Winchil Vaz)
14:45 – Break
15:15 – Phagocytosis and Phagosomal Maturation (Otília Vieira)
16:30 – End

Tuesday, November 9
9:00 – Host-pathogen interactions and manipulation of the cellular trafficking pathways: the example of vaccinia virus (Victor Hsu)
10:00 – Break
10:15 - paper 1: (Selected by Victor)
11:15 –paper 2: (Selected by Otília)
12:00 – Lunch Break

14:00 – Paper 3: (selected by Winchil)
15:00 - End

Wednesday, November 10
9:30 – Antigen processing and presentation and cross-presentation (Duarte Barral)
10:30 - Break
11:15 –paper 4: (Selected by Duarte)
12:00 – Lunch Break

12:30 – Lunch Break
14:00-15:00 - Strategies to evade immunity (Duarte Barral)
16:00 – Seminar – Title TBA (Victor Hsu)
20:00 – “official” course dinner.

Thursday, November 11
9:00 – M. avium: protective immunity and pathology- Part I (Rui Appelberg)
10:00 – Break
10:30 – M. avium: protective immunity and pathology- Part II (Rui Appelberg) 11:45 – Lunch Break

14:00 – Interplay between virus and host cells: How help and restriction can modulate HIV-1 replication? (João Gonçalves)
15:15 - Paper 5: (selected by Rui Appelberg)
16:30 - Paper 6: (selected by João)
17:45 - End

Friday, November 12
9:00 – The type of the host cell death has implications for tuberculosis - Part I (Heinz Remold)
10:00 – break
10:30 -11:30 Paper 7: (selected by Heinz).

14:00 – The type of the host cell death has implications for tuberculosis - Part II (Heinz Remold)
15:00 - End


Paper 1: Ana Gregório and Ângela Fernandes
Paper 2:  Carla Lopes and Carla Paiva
Paper 3:  Fátima Martins and Joana Vindeirinho
Paper 4:  Joana Pinto, Pedro Gouveia and Michelle Viegas
Paper 5:  Rodrigo Santos and Rui Benfeitas
Paper 6:  Sofia Ribeiro, Sonya Costa and Katia Mesquita

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