Home
About BEB
Curriculum
Admission
CNC Research
BEB in the Media
 
 
Neurodegenerative disorders: clinical and neuropathological aspects
 
October 11 - 15
Responsible: Ana Cristina Rego
BEB Course - “NEURODEGENERATIVE DISORDERS –
CLINICAL AND NEUROPATHOLOGICAL ASPECTS”
October 11-15, 2010



Coordinators: Ana Cristina Rego, Paula Agostinho, Cláudia Pereira, Luís Pereira de Almeida


Aim: This course will focus on the latest research in the field of neurodegenerative diseases, affecting both central and peripheral nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), polyglutamine (polyQ) expansion diseases (e.g. Machado-Joseph disease (MJD) and Huntington’s disease (HD)) and familial amyloid polyneuropathy (FAP). Moreover, this year we will analyse the neurodegenerative outcome of other brain disorders, such as epilepsy and ischemia. Clinical and neuropathological aspects of these disorders will be introduced by portuguese clinical physicians. The course is intended to promote the understanding of molecular mechanisms operating in these diseases and their correlation with clinical alterations. Although there is currently no cure for these devastating neurodegenerative disorders, new treatments are on the horizon as a result of accelerating insights into the biology of the diseases. Currently, the development of animal models for neurodegenerative disorders is a major challenge, since they give important insights about the mechanism of toxicity and are useful to test potential therapeutics. Moreover, these neurodegenerative diseases are a current focus of research by several groups at the CNC.

Course Schedule:

Monday (Oct 11)

10:00-10:30- Presentation of students and speakers. Presentation of student s assignments
Overview of neurodegenerative disorders
Ana Cristina Rego

10:30-11:30- Introduction to Huntingtons disease. Searching for protection in Huntingtons disease – role of insulin growth factor-1 and insulin
Ana Cristina Rego

11:30-11:45- Break

11:45-12:30- Introduction to Parkinsons disease. Mitochondrial metabolism in sporadic Parkinsons disease
Sandra Cardoso

12:30-14:30- Lunch

14:30-15:00- Clinical features of Parkinson s disease
Cristina Januário

15:00-15:30- Clinical features of Huntington s disease
Cristina Januário

15:30-16:00- Clinical features of Epilepsy
Francisco Sales 

Tuesday (Oct 12)

10:00-11:00- Introduction to Alzheimer s disease. Endoplasmic reticulum stress response in Alzheimers disease
Cláudia Pereira

11:00-11:30- Break

11:30-12:00- Introduction to Prion Diseases. Toxicity of Prion and amyloid-beta peptides
Paula Agostinho

12:00-14:30- Lunch


14:30-15:30- The good and the bad guys in Parkinsons disease 

Graça Baltaza
r

15:30-16:00- Modelling and modifying Machado-Joseph disease with viral vectors

Luís P. Almeida


16:00-17:00- Why do we need model systems for the analysis of neurodegenerative disorders?
 Thorsten Schmidt



Wednesday (Oct 13)

9:30-10:30- The generation and analysis of (transgenic) mouse models
Thorsten Schmidt

10:30-11:00- Break

11:00-12:00- Animal models of Machado-Joseph disease: from worm to mouse to human
Patrícia Maciel

12:00-12:30- Mitochondrial preconditioning as a potential therapy for Alzheimers disease
Paula Moreira

12:30-14:30- Lunch

14:30-15:00- Synaptotoxicity in animal models of memory impairment
Rodrigo Cunha

15:00-15:30- Neurodegeneration mediated by proteases in epilepsy
Inês Araújo

15:30-16:00- Epilepsy, inflammation and neurogenesis - overreaction in the core of the electric storm
João O Malva


Thursday (Oct 14)

9:30-10:00 Clinical aspects of Alzheimers disease

Isabel Santana

10:00-11:00- The importance of the intracellular localization of the affected protein in polyglutamine diseases
Thorsten Schmidt

11:00-11:30- Break

11:30-12:30- Presentations (max. 20 min/group)
Group 1- Ana Cristina Gregório & Fátima Martins & Sandra Rebelo
Paper 1- A Mouse model of amyloid oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo

Group 2- Ângela Fernandes & Pedro Gouveia & Inês Coelho
Paper 2- Cellular prion protein mediates impairment of synaptic plasticity by amyloid- oligomers
              
      S1

12:30-14:00- Lunch

14:00-16:30- Presentations (max. 20 min/group)
Group 3- Carla Lopes & Rodrigo Santos & Joana Vindeirinho
Paper 3- Mutant huntingtin alters cell fate in response to microtubule depolymerization via GEF-H1-RHOA-ERK pathway.

Group 4- Carla Paiva & Sonya Costa & Rui Benfeitas & Sílvia Catarina Gomes
Paper 4- Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Group 5- Maria Joana Pinto & Sofia Ribeiro & Joana Neves & Diana Silva
Paper 5- Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.



Friday (Oct 15)

9:30-10:00- Stroke and cerebral ischemia
Armanda Santos

10:00-10:30- Break

10:30-11:30- Unravelling the molecular basis of Parkinsons disease
Tiago Outeiro

11:30-12:30- Therapeutic approaches for familial amyloid neuropathies
Maria João Saraiva

12:30- Lunch

15:00-16:00- Seminar: Analysing the molecular pathogenesis of Spinocerebellar ataxia type 3
Thorsten Schmidt
(University of Tuebingen, Medical Genetics, Tuebingen, Germany)

Students Assignments and Distribution

Students (Groups 1-5) will be asked to consider an assigned paper as representing a pivotal work and prepare a brief project stating what experiments would be important to do next. While briefly mentioning the paper findings, the students should concentrate on which directions the research would take.
Apart from presenting data selected from the paper, presentation of the project should have the following points:
-Title
-State of the Art (include some data from the assigned paper)
-Objectives
-Tasks (maximum 3, including expected results and description)
-Research Team

The fictive projects will be presented (20 min) and discussed (20 min) during Thursday (14 October) morning (11:00-12:30) and afternoon (14:00-16:15).

The evaluation criteria will include:
-    Presence and participation
-    Fictive projects (paper presentation, critical view of paper, proposal novelty and feasibility, hypothesis-driven proposal, expected results)
-  Questionnaire




Affiliations - Lecturers:

Thorsten Schmidt (thorsten.schmidt@med.uni-tuebingen.de)
University of Tuebingen
Medical Genetics
Tuebingen, Germany

Maria João Saraiva (mjsaraiv@ibmc.up.pt)
Molecular Neurobiology Group
Institute of Molecular and Cellular Biology (IBMC)
University of Porto
Porto, Portugal

Tiago Fleming Outeiro (touteiro@gmail.com)
Instituto de Medicina Molecular
Cell and Molecular Neuroscience Unit
Instituto de Fisiologia, Faculdade de Medicina de Lisboa
Lisboa, Portugal

Patrícia Maciel (pmaciel@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho
Braga, Portugal

Cristina Januário (cristinajanuario@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Isabel Santana (isabeljsantana@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Francisco Sales (franciscosales@huc.min-saude.pt)
Hospitais da Universidade de Coimbra (HUC)
Serviço de Neurologia
Coimbra, Portugal

Sandra M. Cardoso (scardoso@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimba, Portugal

Paula Isabel Moreira (pismoreira@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

João Oliveira Malva (jomalva@fmed.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Rodrigo A. Cunha (cunharod@gmail.com)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Graça Baltazar (gbaltazar@ubi.pt)
Universidade da Beira Interior,
Departamento de Ciências Médicas
Covilhã, Portugal

Armanda Santos (aesantos@ci.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal

Inês Araújo (inaraujo@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology
University of Coimbra
Coimbra, Portugal

Paula Agostinho (pmgagostinho@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Cláudia Pereira (claudia.mf.pereira@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

Luís Pereira de Almeida (luispa@cnc.uc.pt; luispa@ci.uc.pt) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal

Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) – Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal

back
 
© 2017 BEB - Doctoral Programme in Experimental Biology and Biomedicine powered by ponto.C