Home
About BEB
Curriculum
Admission
CNC Research
BEB in the Media
 
 
Neurodegenerative Disorders
 
January 25 - 29
Ana Cristina Rego (acrego@cnc.cj.uc.pt), Paula Agostinho (pagost@cnc.cj.uc.pt), Cláudia Pereira (cpereira@cnc.cj.uc.pt), Luis Pereira Almeida (luispa@ci.uc.pt)
BEB PhD Programme
Course Schedule-“Neurodegenerative disorders
January 25-29, 2010
 
Monday (Jan 25)
 
9:30-10:00- Presentation of students and speakers

10:00-11:00- Alzheimer s disease: unraveling the mystery
Pavel Pavlov
 
11:00-11:15- Break
 
11:15-12:15- Introduction to Huntington s disease
Sandrine Humbert
 
12:15-14:00- Lunch
 
14:00-15:00- Pathological mechanisms leading to neuronal death in Huntington s disease.
Sandrine Humbert
 
15:00-15:15- Break
 
15:15-15:45- Searching for protection in Huntington s disease – role of insulin growth factor-1 and insulin
A. Cristina Rego
 
15:45-16:00- Presentation of student s assignments
 
 
Tuesday (Jan 26)
 
9:30-10:30- Amyloid and tau
Pavel Pavlov
 
10:30-11:00- Break
 
11:00-11:30 - Endoplasmic reticulum stress response in Alzheimer s disease
Cláudia Pereira
 
11:30-12:00- Cyclin-dependent kinase 5 (Cdk5) and cell cycle deregulation in animal models of Alzheimer s disease
Paula Agostinho
 
12:00-12:30- Clinical aspects of Alzheimer s disease
Isabel Santana
 
12:30-14:30- Lunch
 
 14:30-15:15- Clinical features of Parkinson s disease
Cristina Januário

 15:15-15:30- Break
 
15:30-16:15- Clinical features of Huntington s disease
Cristina Januário
 
 
Wednesday (Jan 27)
 
9:30-10:30- Energy crisis - role of mitochondria
Pavel Pavlov
 
10:30-11:00- Break
 
11:00-12:00 - Function and dysfunction of huntingtin in the control of intracellular dynamics
Sandrine Humbert
 
12:00- 12:45- The molecular basis of Parkinson s disease: from molecules to cures
Tiago Outeiro
 
12:45-14:30- Lunch
 
14:30-15:15- Molecular Genetics of Machado-Joseph disease
Patrícia Maciel
 
15:15-15:30- Break
 
15:30-16:00- Modelling and modifying Machado-Joseph disease with viral vectors
Luís P. Almeida
 
16:00-16:30- Nucleocytoplasmic shuttling activity of ataxin-3, the expanded protein in Machado-Joseph disease
Ana Luísa Carvalho
 
 
Thursday (Jan 28)
 
9:30-10:30- Phosphorylations of huntingtin: functions in health and disease
Sandrine Humbert
 
10:30-11:00- Break
 
11:00-12:00- Alzheimer s disease therapy: an update
Pavel Pavlov
 
12:00-14:30- Lunch and students assignments

14:30-15:00- Mitochondrial metabolism in sporadic Parkinson s disease
Sandra Cardoso

Project presentations by students (based on original papers)
 15:00-15:45- Group 1
 
15:45-16:00- Break
 
16:00-16:45- Group 2
 
 
Friday (Jan 29)
 
10:00- Project presentations by students (based on original papers)
10:00-10:45- Group 3
10:45-11:30- Group 4
11:30-11:45- Break
11:45-12:30- Group 5
 
16:00-17:00- Seminar
“A new function of huntingtin in mitosis and neurogenesis”
Sandrine Humbert
 
 
Students Assignments and Distribution
The students (Groups 1-5) will be asked to consider an assigned paper as representing a pivotal work and prepare a brief project stating what experiments would be important to do next. While briefly mentioning the paper findings, the students should concentrate on which directions the research would take.
Apart from presenting data selected from the paper, presentation of the project should have the following points:
- Title
- State of the Art (includes selected data from the assigned paper)
- Objectives
- Tasks (maximum 3, including expected results and description)
- Research Team
 
The fictive projects will be presented (30 min) and discussed (15 min) during Thursday (Jan 28) afternoon and Friday (Jan 29) morning.
 
Group 1: A. Raquel Martins, Cláudio Roque, Humberto Ferreira
 
Group 2: Ângela Crespo, Paula Banca        
 
Group 3: Ana C. Moreira, Patrícia Monteiro; Marta Vieira
 
Group 4: Helena Leitão, Marília Cordeiro; Joana Fernandes
 
Group 5: Ana L. Pinho, Miranda Mele, Carlos Matos
 
Group 6: Judy Folques Vicente de Paulo 

Affiliations - Lecturers:
 
Sandrine Humbert (sandrine.humbert@curie.u-psud.fr)
Institut Curie
Centre Universitaire
Orsay, France
 
Pavel Pavlov (pavel.pavlov@ki.se)
Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, NVS, Novum, Huddinge, Sweden
 
Tiago Fleming Outeiro (touteiro@gmail.com)
Instituto de Medicina Molecular
Cell and Molecular Neuroscience Unit
Institute of Physiology, Faculty of Medicine Medicina de Lisboa
Lisboa, Portugal


Patrícia Maciel (pmaciel@ecsaude.uminho.pt)
ICVS - Life and Health Sciences Research Institute
University of Minho
Braga, Portugal
 
Isabel Santana (isabeljsantana@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
Cristina Januário (cristinajanuario@gmail.com)
University Hospital of Coimbra (HUC)
Neurology Service
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
Ana Luísa Carvalho (alc@ibili.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Science and Technology, University of Coimbra
Coimbra, Portugal
 
Sandra M. Cardoso (scardoso@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
 
Paula Agostinho (pmgagostinho@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
Cláudia Pereira (claudia.mf.pereira@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
Luís Pereira de Almeida (lpereiradealmeida@gmail.com) - Organizer
Center for Neuroscience and Cell Biology
Faculty of Pharmacy, University of Coimbra
Coimbra, Portugal
 
Ana Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt) – Organizer
Center for Neuroscience and Cell Biology
Faculty of Medicine, University of Coimbra
Coimbra, Portugal
 
Additional Papers
back
 
© 2017 BEB - Doctoral Programme in Experimental Biology and Biomedicine powered by ponto.C