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Mitochondrial Bioenergetics
 
November 23 - 27
Paulo J. Oliveira

pauloliv@ci.uc.pt

“Mitochondria: From the Basics to the Clinic”
November 23-27, 2009
Organization: Paulo J. Oliveira, Ph.D.
Invited Lecturers
Lectures I (40 minutes + 10 discussion)
 
Antonio Ascencao (University of Porto, Portugal)
Antonio Moreno (University of Coimbra, Portugal)
Fabio Di Lisa (University of Padova, Italy)
Jorge Oliveira (University of Porto, Portugal)
Massimo Zeviani (National Neurological Institute "C. Besta", Italy)
 
Lectures II (30 minutes + 10 minutes of discussion)
 
Ana Cristina Rego (CNC, University of Coimbra, Portugal)
Anabela Rolo (CNC, University of Coimbra, Portugal)
Carlos Palmeira (CNC, University of Coimbra, Portugal)
Joao Laranjinha (CNC, University of Coimbra, Portugal)
Luisa Diogo (Hospital Pediatrico de Coimbra, Portugal)
Manuela Grazina (CNC, Universidade de Coimbra, Portugal)
Paula Moreira (CNC, University of Coimbra, Portugal)
Paulo Oliveira (CNC, University of Coimbra, Portugal)
Pedro Monteiro (University of Coimbra, Portugal)
Rui Carvalho (CNC, University of Coimbra, Portugal)
Sandra Amaral (CNC, University of Coimbra, Portugal)
Vilma Sardao (CNC, University of Coimbra, Portugal)
 
 
Program:
Monday (November 23)
THE BASICS
9:00 – 9:15: Introduction to the course (Paulo Oliveira)
9:15 – 10:15: “Back to the basics – The many functions of mitochondria” (Antonio Moreno) – in Portuguese
10:15 – 10:55: “Nitric oxide in the regulation of mitochondrial metabolism and function” (Joao Laranjinha)
11:00 – 11:50: “The mitochondrial permeability transition in cardiovascular pathophysiology” (Fabio Di Lisa)
11:50 – 12:40: “Assessing in situ mitochondria function in living cells” (Jorge Oliveira)
Lunch break
MITOCHONDRIAL MEDICINE AND PATHOLOGY I
14:30 – 15:20: “Mitochondria dynamics in tripartite-synapses” (Jorge Oliveira)
15:20 – 16:00: “Mitochondrial-associated oxidative stress in Huntington s disease - can we prevent it?” (Ana Cristina Rego)
16:00 – 16:40: “BDNF control mitochondrial deregulation and neuronal death in Huntington s disease models” (Ana Cristina Rego)
16:40 – 17:10: “Mitochondrial dysfunction in Alzheimer s disease” (Paula Moreira)
17:10 – 17:50: “Mitochondria as therapeutic targets in neurodegeneration” (Paula Moreira)
 
Tuesday (November 24)
 MITOCHONDRIAL MEDICINE AND PATHOLOGY II
9:30 – 10:20: “Mitochondrial ROS formation and cardiac diseases” (Fabio Di Lisa)
10:20 – 11:20: “Mitochondria as a Toxicity Biosensor – Impact for Drug Safety” (Paulo Oliveira)
11:20 – 12:00: “Mitochondrial fitness in metabolic syndrome and diabetes” (Carlos Palmeira)
12:00 – 12:40: “Mitochondria and protective pathways in hepatic ischemia/reperfusion” (Anabela Rolo)
Lunch break
MITOCHONDRIAL MEDICINE AND PATHOLOGY III
14:30 – 15:10: “Myocardial ischemia: lessons from the cell” (Pedro Monteiro)
15:10 – 17:00: Student’s presentations (evaluators: Jorge Oliveira, Carlos Palmeira, Anabela Rolo, Fabio Di Lisa)
 
a) Mitochondrial biogenesis – stimulus and mechanisms (Angela Crespo, Helena Leitão)
b) Mechanisms of mitochondrial fusion and fission (Ana Pinho, Humberto Ferreira)
c) Anti-ischemic mitochondrial drugs and cardiac damage during ischemia and reperfusion (Susana Pereira, Miranda Mele)
 
Wednesday (November 25)
MITOCHONDRIAL MEDICINE AND PATHOLOGY IV
09:30 – 10:10: “Doxorubicin-induced cardiac mitochondrionopathy” (Paulo Oliveira)
10:10 – 10:50: “Experimental Strategies to Follow the Mitochondrial Apoptotic Pathway: The Example of Doxorubicin-induced Cell Death” (Vilma Sardao)
10:50 – 11:40: “Physical exercise as a modulator stimulus for mitochondrial function” (Antonio Ascensao)
Lunch break
MITOCHONDRIAL MEDICINE AND PATHOLOGY V
14:30 – 17:20: Student’s presentations II (evaluators: Paulo Oliveira, Paula Moreira, Antonio Ascensao, Jose Magalhaes)
 
a) Is there a clear mitochondrial phenotype in cancer cells? (Ana Moreira, Cláudio Roque)
b) Mitochondrial-targeted antioxidants: is there a future? (Ana Martins, Bárbara Rocha)
c) High-throughput methods to evaluate mitochondrial function (Inês Aleixo, Carlos Rodrigues)
d) Studying mitochondrial function in yeast: methods, advantages and uses (Liliana Letra, Carla Graciana)
 
Thursday (November 26)
MITOCHONDRIAL MEDICINE AND PATHOLOGY VI
09:30 – 10:20: “Mitochondrial disorders: a biochemical and molecular introduction” (Massimo Zeviani)
10:20 – 11:00: “Experimental design for laboratory investigation of dual genomic OXPHOS diseases” (Manuela Grazina)
11:00 – 11:40: “Metabolic Remodeling Associated With Subchronic Doxorubicin Cardiomyopathy” (Rui Carvalho)
12:10 – 12:50: “A mitochondrial approach for diabetes, age and male fertility” (Sandra Amaral)
Lunch break
MITOCHONDRIAL MEDICINE AND PATHOLOGY VII
14:30 – 15:10: “Berberine targets mitochondria in melanoma cells” (Paulo Oliveira)
15:10 – 17:00: Student’s presentations III (evaluators: Massimo Zeviani, Sandra Amaral, Vilma Sardao, Rui Carvalho)
 
a) Recent views on mitochondrial DNA genetics (Inês Gonçalves, Marília Cordeiro)
b) Role of cardiolipin in mitochondrial apoptotic involvement (Ana Carvalho, Patrícia Monteiro)
c) Is there a role for p53 in mitochondria? (Paula Branca, Rui Soares)
d) Mitochondrial DNA in forensic medicine (Ana Eufrásio,…)
 
 
Friday (November 27)
MITOCHONDRIAL MEDICINE AND PATHOLOGY VIII
9:30 – 10:20: “Disorders of intergenomic communication” (Massimo Zeviani)
10:20 – 11:00 “Mitochondrial respiratory chain disorders in children – a clinical diagnosis approach” (Luisa Diogo)
11:00 – 12:30: Presentations by non-BEB graduate students of the CNC on the topic of the course
Sonia Correia: “Protection by mitochondrial ROS preconditioning: HIF-1α as a novel candidate to minimize high glucose-associated brain endothelium damage”
Marco Alves: “Mitochondrial function and cell death in cardioplegic preserved hearts: effects of ischemia and ischemia-reperfusion”
Susana Cardoso:” Effects of streptozotocin-induced diabetes and insulin-induced hypoglycemia on brain mitochondria”
Sandro Pereira:”Mitochondrial involvement in stem cell differentiation”
José Lumini: “Endurance Training Improves Gastrocnemius Mitochondrial Respiratory Function Despite Increasing MPTP Susceptibility in Diabetes”
Lunch break
14:00 – 16:00: Free time
16:00 – 17:00: CNC Friday Seminar - “Unconventional mechanisms of mitochondrial dysfunction” (Massimo Zeviani)
 
 
Student evaluation:
The students should put themselves in the shoes of a senior lecturer and present a general review seminar on a topic that fits in the theme of the course. Groups of two students will be made and each group will have 15 minutes plus 5 minutes of discussion to present a topic that will be suggested by the organizer but that will not be covered by any speaker in detail. The presentation will be made in English and using Powerpoint. The students are advised to consult literature in the field (review papers especially) but always more than one recent paper. It is not enough to simply present one review paper. Higher consideration will be given if the students present their critical view on the subject or if they include very recent published research data together with their review.
 
 
Contacts (non-BEB students)
Susana Pereira - pereirasusan@gmail.com
Bárbara Rocha - babiisr@hotmail.com
Ana Carvalho - ana3carvalho@gmail.com
Inês Aleixo - inesmaleixo@hotmail.com
Inês Gonçalves - i.goncalves@live.com.pt
Rui Soares - ruinetsoares@hotmail.com
Liliana Letra - lilianarvletra@hotmail.com
Carla Graciana - carlagraciana@aeiou.pt
Ana Eufrásio - eufrana@gmail.com
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