MOLECULAR CELL BIOLOGY
Coordinators: Edgar R. Gomes (UPMC, Paris, France), Carlos B. Duarte (U. Coimbra, Portugal)
U. of Pennsylvania, Philadelphia USA &
Institut Curie, Paris
Dept. of Biochemistry
Edgar R. Gomes
U. Pierre et Marie Curie, Paris
IBMC, U. do Porto, Porto
Tuesday, October 6
9:30 - Introduction
10:00 – A tale of three filaments I (Edgar)
11:00 - A tale of three filaments II (Edgar)
11:45 – Lunch break
13:45 - Imaging in Cell Biology (part I) (Phong)
14:45 – Break
15:15 – Imaging in Cell Biology (part II) (Phong)
16:30 – End
Wednesday, October 7
9:00 – Controlling the cytoskeleton (Edgar)
10:00 – Break
10:15 - paper 1: (Selected by Phong)
11:15 –paper 2: (Selected by Phong)
12:00 – Lunch Break
14:00 – Mitosis ( Helder)
15:15 - Paper 3: (selected by Helder)
16:30 - Paper 4: (selected by Edgar)
17:45 - End
Thursday, October 8
9:00 – Cell Polarity and the Localization of Ribonucleoprotein Complexes (Alex)
10:15 – Break
10:30 – Assembling the Ribonucleoprotein Complex (Alex)
11:45 – Lunch Break
14:00 – Paper 5: (selected by Alex)
15:15 - Paper 6: (selected by Alex)
16:30 - End
20:00 – “official” course dinner.
Friday, October 9
11:00 – Paper 7: (selected by Edgar)
12:30 – Lunch Break
16:00 – Seminar – “Specialized Nuclear Export of mRNA Encoding Secretory and Mitochondrial Proteins” Alexander Palazzo
Papers for the journal club:
Fu, C., Ward, J. J., Loiodice, I., Velve-Casquillas, G., Nedelec, F. J., and Tran, P. T. (2009). Phospho-Regulated Interaction between Kinesin-6 Klp9p and Microtubule Bundler Ase1p Promotes Spindle Elongation. Developmental Cell 17, 257-267.
Khmelinskii, A., Roostalu, J., Roque, H., Antony, C., and Schiebel, E. (2009). Phosphorylation-Dependent Protein Interactions at the Spindle Midzone Mediate Cell Cycle Regulation of Spindle Elongation. Developmental Cell 17, 244-256.
Liu, D., Vader, G., Vromans, M. J. M., Lampson, M. A., and Lens, S. M. A. (2009). Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates. Science 323, 1350-1353.
Campellone, K. G., Webb, N. J., Znameroski, E. A., and Welch, M. D. (2008). WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport. Cell 134, 148-161.
Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet O, Ephrussi A. Nature. 2004 Apr 29;428 (6986):959-63.
The signal sequence coding region promotes nuclear export of mRNA. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. PLoS Biol. 2007 Dec;5(12):e322.
Gomes, E. R., Jani, S., and Gundersen, G. G. (2005). Nuclear Movement Regulated by Cdc42, MRCK, Myosin, and Actin Flow Establishes MTOC Polarization in Migrating Cells. Cell 121, 451-463.