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Diabetes and Vascular Disease
 
March 27 - 31
Coordinators: Raquel Seiça and Cristina Sena

Lecturers:
 
 
 
Fundación Centro Nacional de Investigaciones, Cardiovasculares Carlos III, Sinesio Delgado, 4, 28029 Madrid, Spain
 
Fausta Natella
 
National Institute for Food and Nutrition Research, via Ardeatina 546, I-00178 Rome, Italy
 
 
Professor of Pharmacology, Director of the Cell Signaling Laboratory, Leicester School of Pharmacy, The Hawthorn Building, De Montfort University, Leicester LE1 9BH, UK, United Kingdom
 
Franscisco Ambrósio
 
Biophysics and Biomathematics Department, IBILI, Faculty of Medicine, Celas, Coimbra, Portugal
 
Sérgio Lemos
 
Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Coordinators:
 
 
 
 
Instituto de Fisiologia, Faculdade de Medicina, Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal


Objective of the course
The most common form of diabetes is type 2 diabetes. This form of diabetes is associated with older age, obesity, family history of diabetes, previous history of gestational diabetes, physical inactivity, and ethnicity. About 80 percent of people with type 2 diabetes are overweight. type 2 diabetes is increasingly being diagnosed in children and adolescents.
Diabetes is associated with long-term complications that affect almost every part of the body. The disease often leads to blindness, heart and blood vessel disease, strokes, kidney failure, amputations, and nerve damage.
Aim: To overview some of the clinical complications of type 2 diabetes and discuss some of the recent advances in the area.
  • Cardiovascular disease - Cardiovascular disease, in many cases, is caused by atherosclerosis - an excess build-up of plaque on the inner wall of a large blood vessel, which restricts the flow of blood. Heart disease is the leading cause of diabetes-related deaths. Heart disease and stroke are two to four times more common in persons with diabetes. Peripheral vascular disease is atherosclerosis that affects the legs and feet.
  • Hypertension - High blood pressure affects 73 percent of persons with diabetes.
  • Retinopathy or glaucoma (eye disease or blindness) - Blindness due to diabetic retinopathy is a more common cause of visual impairment in younger-onset people than in older-onset people. Males with younger-onset diabetes generally develop retinopathy more rapidly than females with younger-onset diabetes. Diabetes is the leading cause of blindness among adults 20 to 74 years of age.
  • Renal disease (kidney disease) - 10 to 21 percent of all people with diabetes develops kidney disease. Diabetes is the leading cause of end-stage renal disease (ESRD), a condition in which the patient requires dialysis or a kidney transplant in order to live.
COURSE SCHEDULE:
 
Monday 27/03/2006
9:00-10:30
Diabetes Mellitus: classification and diagnosis.
 
Pathogenesis of type 2 diabetes: critical components
 
R. Seiça
11:00-12:00
Oxidative stress and endothelial function in the arterial wall
 
C. Sena
 
 
14:00-15:30
New insights in diabetic retinopathy: a chronic inflammatory and neurodegenerative disease?
 
F. Ambrósio
16:00-17:00
TUTORIAL CLASS (Discussion of research papers)
 
Tuesday 28/03/2006
9:00-10:30
Transcriptional regulation of the mitochondrial ROS protection system.
 
M. Monsalve
11:00-12:00
Nitric oxide, PGC1-alpha and Foxo3a: working together to protect endothelial cells from oxidative stress.
 
M. Monsalve
 
 
14:00-17:00
TUTORIAL CLASS (Discussion of research papers)
 
Wednesday 29/03/2006
 9:00-10:30
Dietary factors affecting atherogenesis: theories
 
Fausta Natella
11:00-12:00
Dietary factors affecting atherogenesis: bench practice
 
Fausta Natella
 
 
16:00-17:00
Journal Club
 
Fausta Natella
 
Thursday 30/03/2006
9:00-10:30
Vascular dysfunction from the standpoint of angiogenesis/vasculogenesis
 
M.R Boarder
11:00-12:00
Journal Club
 
M.R Boarder
 
 
16:00-17:00
Regulation of vascular endothelial cells by receptors.
 
 M.R Boarder
 
Friday 31/03/2006
9:00-10:30
Diabetic nephropathy -the historic evolution of detection, prevention and management.
 
Sérgio Lemos
11:00-12:00
Diabetic nephropathy - Pathogenetic mechanisms of nephropathy.
 
Sérgio Lemos


Research Papers
2ª feira – 16 h
4ª feira – 14 h
 
Ana Margarida Abrantes
 
Gisela Machado da Silva
 
Ângela Castela
 
Helena Sofia Domingues
 
Ana Clara Cristovão
 
Cristiana Paulo
3ª feira – 14 h
4ª feira – 14 h
 
Ana Isabel Teles
 
Joana Cravo Lourenço
 
Carina Sousa dos Santos
 
Lígia Carinha Gomes
 
Ana Rita Costa
 
Márcio Ribeiro
3ª feira – 14 h
5ª feira – 14 h
 
Rui Providência
 
Patrícia Nunes
 
Catarina Sofia Pimentel
 
Mariana Godinho Bexiga
 
Eduardo Miguel Ferreira
 
Ricardo José Soares
 
 
5ª feira – 14 h
 
 
 
Ricardo Miguel Marques
 
 
 
Maria Nascimento
 
 
 
Paulo Matafome

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