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Structural Biology: Amyloidosis
 
February 6 - 10
Coordinators: Rui Brito and Sandra Ribeiro

Invited Lecturers:
 
Daniel A. Kirschner (PhD), Boston College, USA
 
 
Sheena E. Radford (PhD) Astbury Centre for Structural Molecular Biology, Garstang Building, University of Leeds, Leeds, LS2 9JT, UK
 
 
Steven Finkbeiner (MD, PhD), Gladstone Institute of Neurological DiseaseUniversity of California, San Francisco, USA
 
Coordinators:
 
 
 
Center for Neuroscience and Cell Biology and Chemistry Department, University of Coimbra
 
 
Center for Neuroscience and Cell Biology, University of Coimbra
Specific title:
Molecular mechanisms of amyloid formation: Protein Stability, Folding and Aggregation
 
 
Objectives:
Amyloid fibril formation is the hallmark of several neurodegenerative diseases, including Alzheimer´s, spongiform encephalopathies (ex: BSE), Familial Amyloid Polyneuropathy ("doença dos pezinhos") and the Machado-Joseph disease, among many others. In most of these diseases, it has been shown that the normal soluble precursor protein, due to proteolysis, mutation or chemical stress, undergoes misfolding, leading to molecular species with a high tendency for ordered aggregation into amyloid.
The objective of the present course is to highlight the role of structural biology and biophysical chemistry in the elucidation of the molecular mechanisms of amyloid diseases and in the development of rational therapeutic strategies to prevent such devastating pathologies.
COURSE SCHEDULE:
 
Monday (Feb 06)
9:30-10:30
How do proteins fold (I)? Tools and techniques
 
Sheena Radford
11:00-12:00
How do proteins fold (II)? Insights from combining experiment and simulation
 
Sheena Radford
 
 
14:30-18:00 
Groups IV, V, VI and VII: Structure visualization and data retrieval
 
Sandra Ribeiro & Rui Brito
 
Groups I, II and III: Paper preparation
 
Sheena Radford
 
Tuesday (Feb 07)
9:30-11:00
Mechanisms of protein misfolding:
 
-The basics of amyloidosis
 
-Molecular insights and potential therapeutic routes
 
Sheena Radford
12:00-13:00
SEMINAR
 
Finding a needle in a haystack: Identifying the culprits of amyloidosis
 
Sheena Radford
 
 
15:00-18:00
Journal Club I
15:00-15:30
15:45-16:15
16:30-17:00
 
Wednesday (Feb 08)
9:30-10:30
Overview: The Problem
 
Daniel Kirschner
11:00-12:00
Structural Biological approaches
 
Daniel Kirschner
 
 
14:30-17:30
Groups I, II and III: Structure visualization and data retrieval
 
Sandra Ribeiro & Rui Brito
 
Groups IV, V, VI and VII: Paper preparation
 
Daniel Kirschner
 
Thursday (Feb 09)
9:30-10:30
X-ray Diffraction
 
Daniel Kirschner
11:00-12:00
Amyloid: Variations on the theme of Twist and Sheet
 
Daniel Kirschner
 
 
14:30-17:30
Journal Club II
14:30-15:00
15:15-15:45
16:00-16:30
16:45-17:15
 
Friday (Feb 10)
9:30-11:00
Overview and discussion of “ hot topics”
 
 
14:30-15:30
Seminar I: Elucidating toxic species in huntingtin-induced neurodegeneration.
 
(Location: IBILI Auditorium)
 
Steven Finkbeiner
16:00-17:00
Seminar II: Amyloid Structure & Amyloid Inhibition: a fiber diffraction approach.
 
(Location: IBILI Auditorium)
 
Daniel Kirschner
Publications of invited speakers and coordinators
 
Invited speakers
 
Daniel A. Kirschner
 
Sheena E. Radford
 
Steven Finkbeiner
 
Coordinators
 
Sandra Macedo-Ribeiro
 
Rui M. M. Brito

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