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Neuromodulation
 
January 16 - 20
Coordinators: João O. Malva, Ana P. Silva and Armando Cristóvão

Aim of the course
The aim of the course is to provide students with solid evidences that the combined use of molecular biology, imaging, pharmacology and electrophysiology is a potent experimental strategy. In this course, lectures and discussion groups focusing on advanced techniques and research projects will be coordinated by leaders in the field of glutamatergic neurotransmission and modulation. Major implications for the molecular and cellular basis of epilepsy and obesity will be discussed.
 
Program
 
January 16
9:15-10:45
General Lecture
 
Epilepsy
 
W. Colmers
11:00-12:30
General Lecture
 
The GABAergic synapse in epilepsy
 
R. Cossart
 
 
14:00-15:00
Research Lecture
 
Synaptic modulation and excitotoxicity
 
A. Silva
15:00-17:00
Lab Session (G1-2)
 
Organotypic cultures
 
L. Bernardino, B. Silva, S. Xapelli
17:00-19:00
Lab Session (G3-4)
 
Organotypic cultures
 
L. Bernardino, B. Silva, S. Xapelli
 
January 17
9:15-10:45
General Lecture
 
Glutamate receptors and synaptic transmission
 
C. Mulle
11:00-12:30
Research Lecture
 
Imaging neuronal populations in brain slices
 
R. Cossart
 
 
14:00-15:00
Research lecture
 
Inflammation and Epilepsy
 
J. Malva
15:00-17:00
Lab Session (G5-6)
 
Organotypic cultures
 
L. Bernardino, B. Silva, S. Xapelli
 
January 18
9:15-10:45
Research Lecture
 
Synaptic modulation by NPY
 
W. Colmers
11:00-12:30
Research Lecture
 
Synaptic modulation by kainate receptors
 
C. Mulle
 
 
14:00-15:00
Journal club
 
Coordinators: C. Mulle, W. Colmers, R. Cossart
 
January 19
10:30
PhD thesis - Paulo Pinheiro
 
Sala dos Capelos
 
 
14:00-19:00
Projects
 
January 20
9:15
Projects Discussion
 
Coordinators: J. Malva, A. Silva, A. Cristóvão
 
 
16:00
SEMINAR
 
W. Colmers


Grupo 1: Carina de Sousa Santos; Mariana Godinho Bexiga
 
Grupo 2: Ana Isabel Teles; Joana Catarina Lourenço
 
Grupo 3: Gisela Machado Silva; Lígia Carinha Gomes
 
Grupo 4: Catarina Sofia Pimentel; Ricardo Miguel Marques
 
Grupo 5: Helena Sofia Domingues; Ricardo José Soares
 
Grupo 6: Ana Clara Cristóvão; Eduardo Miguel Ferreira


Affiliation and contacts
Christophe Mulle - Physiologie Cellulaire de la Synapse, UMR CNRS 5091, Institut François Magendie, Bordeaux
Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Bettler B, Heinemann SF. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature. 1998 392(6676):601-5.
Jaskolski F, Coussen F, Mulle C. Subcellular localization and trafficking of kainate receptors. Trends Pharmacol Sci. 2005 26(1):20-6.
 
William Colmers - Department of Pharmacology, University of Alberta, Edmonton, Canada
Vezzani A, Sperk G, Colmers WF. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 1999 22(1):25-30.
Pentney AR, Baraban SC, Colmers WF.NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy. J Neurophysiol. 2002 88(5):2745-54.
 
Rosa Cossart - INMED-INSERM, 163 Route de Luminy, Marseille, France
Cossart R, Bernard C, Ben-Ari Y.Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies. Trends Neurosci. 2005 28(2):108-15.
Cossart R, Aronov D, Yuste R. Attractor dynamics of network UP states in the neocortex. Nature. 2003 ;423(6937):283-8.
 
Coordinators - Center for Neuroscience and Cell Biology - University of Coimbra
Bernardino, L., Xapelli, S., Silva, A.P., Poulsen, F.; Jakobsen, B., Oliveira, C.R., Vezzani, A., Malva, J.O. and Zimmer J. (2005) Modulator effects of Interleukin 1-beta and Tumor Necrosis Factor alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J. Neurosci. 25: 6734-6744.
Silva, A.P.; Xapelli, S; Pinheiro, P.S.; Ferreira, R.; Lourenço, J.; Cristóvão, A.; Grouzmann, E.; Cavadas, C.; Oliveira, C.R. and Malva, J.O. (2005) Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats. J. Neurochem. 93:163-170.
Silva, A. P., Pinheiro, P. S., Carvalho, A. P., Carvalho, C.M., Jakobsen, B., Zimmer, J. and Malva, J. O (2003) Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. FASEB J. 17: 1118-1120 (published on line FASEB J. express10.1096/fj.02-0885fje, April 8).

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