About BEB
CNC Research
BEB in the Media
December 5 - 9
Coordinator: Rodrigo Cunha

Molecular Neurobiology Lab., Dept. Neurology, Boston Univ. School of Medicine, Boston, 02129 – Massachussetts – USA
Dept. Anatomy and Neurobiology, Institute of Medical Biology, Odense Univ., Winsløwparken 21, DK-5000 Odense C – DENMARK
New England Inflammation and Tissue Protection Institute, Northeastern Univ., 360, Huntington Ave, 134 Mugar Health Sciences Building, Boston, MA 02115, USA
Objectives of the course
  • pharmacology versus trangenics in the study of receptors
  • homeostasis and inter-cellular communication: the role of adenosine
  • neuromodulation and protection against damage in the brain
  • role of neurons and glia cells in brain damage
  • control of peripheral inflammation and neuro-inflammation  
  • control of tissue damage as an inter-disciplinary problem
  • neuroscience is much more than just about neurons
  • science as the edge of the unknown
  • appreciate a leading candidate theme for a thesis
  • participate in the discussion of a cutting-edge scientific problem with leader scientists in the area
  • contact the lab ‘Purines at CNC’ and other group leaders as possible labs to work in the future
Monday 5th December
14h00 – 14h30:
Presentation of the contents, teachers and goals of the course
14h30 – 15h30:
Adenosine as a general homeostatic signal
16h00 – 17h00:
Adenosine receptors: pharmacological tools for their study
17h30 – 18h30:
Adenosine receptors: use of trangenic animals for their study
Tuesday 6th December
09h00 – 10h00:
Modulation of neuronal function by adenosine
10h30 – 11h30:
Adenosine and neuroprotection
12h00 – 13h00:
Adenosine and neuroprotection: from neurons to glia
14h30 – 15h30:
Physio-pathological role of glia cells in the brain
16h00 – 17h00:
Microglia: the inflammatory/immune system of the brain
17h30 – 18h30:
Infiltration of peripheral immune cells in the brain
Wednesday 7th December
09h00 – 10h00:
The peripheral immune system
10h30 – 11h30:
Role of the immune system in tissue damage (physiological aspects)
14h00 – 15h00:
Role of the immune system in tissue damage (molecular aspects)
15h30 – 16h30:
Control by adenosine of the inflammatory/immune system
17h00 – 18h00:
Opposite control by adenosine of inflammation and neuro-inflammation
Thursday 8th December
09h30 – 11h00:
Attendance of students to help them prepare their presentations
Friday 9th December
09h30 – 15h00:
How can the control by adenosine of glia cells impact on neurodegeneration (presentation by students of selected papers on the topics adenosine/microglia)
16h00 – 17h00:
CNC Seminar
Publications relevant for the course
Fredholm, B.B., Chen, J.F., Masino, S.A., Vaugeois, J.M. (2005) Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annu Rev Pharmacol Toxicol. 2005;45:385-412.

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