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Molecular Neuroscience
 
November 28 - December 2
Coordinator: Ana Luisa Carvalho

Lecturers:
 
 
Andrew Irving
 
Neurosciences Institute, Division of Pathology & Neuroscience, Ninewells Hospital & Medical School, Dundee University, UK
 
 
 
Christopher Connolly
 
Neurosciences Institute, Division of Pathology & Neuroscience, Ninewells Hospital & Medical School, Dundee University, UK
 
 
 
Stuart Cobb
 
Division of Neuroscience and Biomedical Systems, IBLS,University of Glasgow, UK
 
 
 
Ana Luísa Carvalho
 
Center for Neuroscience and Cell Biology Department of Zoology, University of Coimbra, Portugal
 
 
Objective of the course
The course on molecular neuroscience aims at covering background information as well as emergent questions in the field, with a special focus on synaptic plasticity.
COURSE SCHEDULE:
 
Monday
 
9-10.15h:
Synaptic plasticity and memory (overview)          
 
S. Cobb
10.30-11.45h:
Structure and organization of the synapse
 
A. L. Carvalho
 
 
14-15.15h:
Neuronal G-protein coupled receptors - structure, function & regulation
 
A. Irving
Tuesday
 
9-10.15h:
Receptor biogenesis and transport signals
 
C. Connolly
10.30-11.45h:
Trafficking and surface expression of glutamate receptors
 
A. L. Carvalho
 
 
14-17h:
Analysis and discussion of papers
Students presenting:Ricardo José Soares, Joana Cravo Lourenço, Ana Rita Costa
 
Students presenting:Ana Margarida Abrantes, Ricardo Miguel Marques
 
Students presenting: Aurelie Santos, Eduardo Miguel Ferreira, Joana Ferreira
 
Wednesday
 
9-10.15h:
Techniques in molecular neuroscience – confocal imaging, immunohistochemistry & calcium dynamics
 
A. Irving
12-13.15h:
Techniques in molecular neuroscience – protein-protein interactions
 
C. Connolly
 
 
16h:
Seminar: Cannabinoid receptor dynamics
 
Andrew Irving
Thursday
 
9-10.15h:
Role of mitochondria in excitotoxicity
 
C. Connolly
10.30-11.45h:
Molecular mechanisms of synaptic plasticity
 
S. Cobb
 
 
14-17h:
Analysis and discussion of papers
Students presenting:Ana Clara  Cristóvão, Carina Sousa dos Santos, Ana Catarina Fonseca 
 
Students presenting:Helena Sofia Domingues, Lígia Carinha Gomes
 
Students presenting:Vera Gonçalves, Catarina Sofia Pimentel
 
Friday
 
9-10.15h:
Modulators of synaptic plasticity
 
A. Irving
         
10.30-11.45h:
Proteomics of synaptic plasticity
 
S. Cobb
 
 
14-17h:
Analysis and discussion of papers
Students presenting:Mariana Godinho Bexiga, Gisela Machado da Silva, José Cândido Ferrão
 
Students presenting:Ana Isabel Teles, Cátia Marques
 
Background readings:
 
 
 
 
 
 
Affiliation and contacts
Andrew Irving - Neurosciences Institute, Division of Pathology & Neuroscience, Ninewells Hospital & Medical, School, Dundee University, UK. Webpage: http://www.dundee.ac.uk/pharmacology/AI/AI_Home.htm
 
Coutts AA, Anavi-Goffer S, Ross RA, MacEwan DJ, Mackie K, Pertwee RG, Irving AJ. Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons. J Neurosci. 2001 Apr 1;21(7):2425-33.
Rae MG, Irving AJ. Both mGluR1 and mGluR5 mediate Ca2+ release and inward currents in hippocampal CA1 pyramidal neurons. Neuropharmacology. 2004 Jun;46(8):1057-69.
 
 
Christopher Connolly - Neurosciences Institute, Division of Pathology & Neuroscience, Ninewells Hospital & Medical School, Dundee University, UK. Webpage: http://www.dundee.ac.uk/pharmacology/CC/CC_Home.htm
 
Boyd, G.W., Doward, A.I., Kirkness, E.F., Millar, N.S. & Connolly, C.N. (2003) Cell surface expression of 5-HT3 receptors is controlled by an endoplasmic reticulum retention signal. J.Biol.Chem. 278: 27681-27687.
Hales, T.G., Tang, H., Johnson, S.J., Bollan, K.A., King, D.P. McDonald, N.A., Cheng, A., & Connolly, C.N. (2005) The epilepsy mutation, g2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors. Molecular & Cellular Neuroscience (In Press).
 
 
Stuart Cobb - Division of Neuroscience and Biomedical Systems, IBLS,University of Glasgow, UK
 
Cobb SR, Davies CH. Cholinergic modulation of hippocampal cells and circuits.
J Physiol. 2005 Jan 1;562(Pt 1):81-8. Epub 2004 Nov 4. Review.
Roshan-Milani S, Ferrigan L, Khoshnood MJ, Davies CH, Cobb SR. Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation.
Epilepsy Res. 2003 Sep;56(1):51-65.
 
 
Coordinator - Center for Neuroscience and Cell Biology & Department of Zoology, University of Coimbra, Portugal
 
Santos A.E., Duarte C.B., Iizuka M., Barsoumian E.L., Ham J., Lopes M.C., Carvalho A.P., and Carvalho A.L. (2005) Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor. Cell Death & Diff. In press.
Correia S.S., Duarte C.B., Faro C.J., Pires E.V., and Carvalho A.L. (2003) Protein kinase Cg associates directly with the GluR4 a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit: effect on receptor phosphorylation. J. Biol. Chem. 278, 6307-6313.
 

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