About BEB
CNC Research
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Biology of Development
November 14 - 18
Coordinators: Frieder Schoeck and João Ramalho-Santos

Goals/Topics of the course:
We want students to understand the molecular basis of the three crucial events in the development of a multicellular animal, cleavage, pattern formation and morphogenesis. We will illustrate the transcriptional regulation, signaling, and cytoskeletal remodeling underlying these events using early Drosophila development and mouse and chicken limb development as examples.
Students will be asked to present research papers related to the topics under discussion (see below). PowerPoint (or transparencies) should only be used for Figures/Graphs, not bulleted lists of text. Students will also write a short report based on microscope observations that will be carried out during the course

Frieder Schoeck - Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
phone: +1 (514) 398-6434; e-mail: frieder.schoeck@mcgill.ca
Schöck F and Perrimon N (2003). Retraction of the Drosophila germ  band requires cell-matrix interaction. Genes & Development 17, 597-602
Schöck F and Perrimon N (2002). Cellular processes associated with  germ band retraction in Drosophila. Developmental Biology 248, 29-39
Schöck F and Perrimon N (2002). Molecular mechanisms of epithelial morphogenesis. Annual Review of Cell and Developmental Biology 18, 463-493
Christine Hartmann - I.M.P., Research Institute for Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Wien, Austria
phone: +43 (1) 79730-840, e-mail: hartmann@imp.univie.ac.at
home page: http://www.imp.univie.ac.at/hartmann/har_hp.html
Hill TP et al. (2005). Canonical Wnt/beta-catenin signaling prevents   osteoblasts from differentiating into chondrocytes. Dev Cell. 8(5): 727-38.
Hartmann C (2002). Wnt-signaling and skeletogenesis. J Musculoskelet  Neuronal Interact. 2(3):274-6.
Ralph Ruebsam - Developmental Biology Unit, Institute for Biology, University of Erlangen-Nuremberg, Staudtstr. 5, 91058 Erlangen, Germany
Phone: +49 (9131) 8528067, Email: rruebsam@biologie.uni-erlangen.de
Rubsam R et al. (1998). The egghead gene product influences oocyte differentiation by follicle cell-germ cell interactions in Drosophila melanogaster. Mech Dev. 72(1-2):131-40.
Local Contact at the CNC: João Ramalho-Santos (jramalho@ci.uc.pt)

Monday Nov 14
9.00-11.00 AM
Principles of Development; pattern formation in Drosophila from the Bicoid gradient to pair-rule genes (Room 7, Higiene)
Tuesday Nov 15
9.00-10.00 AM
Drosophila segmentation II: Building compartments with segment polarity genes; principles and examples of induction
10.00-11.00 AM
Morphogenesis with gastrulation as main example; interface of patterning genes with cytoskeletal remodeling (Room 7, Higiene)
Microscopy: pattern formation mutants (one hour)
Discussion of papers (open-ended) (Room 7, Higiene)
Wednesday Nov 16
9.00-11.00 AM
Closing the circle: Drosophila oogenesis; establishment of the stem cell niche and of asymmetries during oogenesis; epistasis analysis and classification of mutants (Room 7, Higiene)
Microscopy: Interpretation of gene expression patterns in Drosophila ovarian follicle cells
PM Discussion of papers (open-ended) (Library, Higiene)
Thursday Nov 17
9.00-11.00 AM
Vertebrate limb development; signals involved in limb positioning, initiation and outgrowth (Room 7, Higiene)
Discussion of papers (open-ended) (Room 7, Higiene)
17.30- ??
evening: going out for drinks with PhD students!
Friday Nov 18
9.00-11.00 AM
Patterning of limb muscles and skeleton; where does patterning information come from, how do muscles/skeleton develop (Room 7, Higiene)
Seminar (IBILI Auditorium)

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