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Molecular Cell Biology
 
November 27 - December 1
Carlos Duarte
Monday – Thursday: IBILI Auditorium
Friday : Faculty of Medicine
Coordinators: Carlos B. Duarte (CNC) & Edgar R. Gomes (Columbia University, NY)
Lecturers:
Gregg G. Gundersen
Dep. Anatomy and Cell Biology, Columbia University
New York, USA
http://cpmcnet.columbia.edu/dept/gsas/anatomy/Faculty/Gundersen/
Geri Kreitzer
Dept. of Cell and Developmental Biology 
Weill Medical College of Cornell University
New York, USA
http://www.med.cornell.edu/research/gkreitzer/index.html
Edgar R. Gomes
Dep. Pathology, Columbia University
New York, USA
Helder Maiato
IBMC, Universidade do Porto
Porto

Monday, November 27                                                                
Time – Lecture
10-11:30 – A tale of three filaments (part I) (Gregg Gundersen)
11:30 – Lunch break
13:15 - A tale of three filaments (part II) (Gregg Gundersen)
14:45 – Break
15:15 – Techniques in Cell Biology (part I) (Edgar Gomes)
16:15 – Break
16:30 - Techniques in Cell Biology (part II) (Geri Kreitzer)

Tuesday, November 28                                                               
Time – Lecture
8:30 – Cell Migration I (Edgar Gomes)
10:00 – Break
10:30 – Cell Migration II (Gregg Gundersen)
12:00 – Lunch Break

Wednesday, November 29                                                                     
Time – Lecture
8:30 – Journal Club:
Paper 5:
Stephanie L Gupton et al. (2005) Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J. Cell Biol. 168, 619-631. - [ver Pdf] (Students presenting: Daniel Nunes, Joana Neves)
10:00 – Break
10:30 – Mitosis I (Helder Maiato)
12:00 – Lunch Break
14:00 – Mitosis II (Helder Maiato)
15:30 – Journal Club
Paper 7:
Tarun M Kapoor et al. (2006) Chromosomes can congress to the metaphase plate before biorientation. Science. 311, 388-391. - [ver Pdf]
A Khodjakov et al (1997) Chromosome fragments possessing only one kinetochore can congress to the spindle equator. J. Cell Biology. 136, 229-240. - [ver Pdf]
(Students presenting: Ana Raquel Esteves, Gil Costa, Sara Sousa)
Paper 8:
Olivier Pertz et al. (2006) Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 440, 1069-1072. - [ver Pdf] (Students presenting: Joana Gaspar, Rui Costa)

Thursday, November 30                                                              
Time – Lecture
12:00 Lunch Break
14:45 – Seminar
Centrosome polarization in migrating cells (Edgar Gomes)
15:45 – Break
16:00 – Seminar
Functional Analysis of Kinesins during Epithelial Polarization
(Geri Kreitzer)

Friday, December 1                                                                                 
12:30 – Lunch Break
 
Supplementary Background Readings:
Enrique Rodriguez-Boulan, Geri Kreitzer and Anne Müsch (2005) Organization of vesicular trafficking in epithelia. Nature Rev Mol Cell Biol 6, 233-247.
 
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