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Immunology
 
February 19 - 23
Alexandrina Mendes, Teresa Cruz e Celeste Lopes
Affiliation and contacts:
António Bandeiras
Unite du Developpement des Lymphocytes, Centre National de la Recherche Scientifique, Unite de Recherche Associee 1961, Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France.
Kai Zacharowski
Chair of Anaesthesia & Critical Care
Dept of Anaesthesia, BHI
Bristol Royal Infirmary
Bristol, BS2 8HW, UK
Anabela Cordeiro da Silva
IBMC and Faculdade de Farmacia da Universidade do Porto, Rua Anibal Cunha, 164, 4050-047 Porto, Portugal.
Carmen Garcia-Rodriguez
Instituto de Biología y Genética Molecular
Facultad de Medicina
Avda. Ramón y Cajal 7, 5º
47005 Valladolid
Spain


Schedule:
Monday, February 19th
10.30-11.45 h: Lecture 1: The innate immune system
Kai Zacharowski

14.00-15.15h: Lecture 2: The adaptive immune system
Kai Zacharowski

Tuesday, February 20th
9.00-10.15 h: Lecture 3: Cellular and molecular mechanisms of inflammation
Kai Zacharowski

10.30-11.45 h: Lecture 4: Gene expression in the immune system.
Carmen Garcia-Rodriguez

14.00-15.15h: Presentation and discussion of papers – Session 1
(3 papers: 14:00h-15h45)

Wednesday, February 21st
10.30-11.45 h: Lecture 5: Immunology to infection and cellular targets of immunomodulator proteins
Anabela Cordeiro da Silva

14.00-15.15h: Lecture 6: TLR signalling and pathology.
Carmen Garcia-Rodriguez

15.45-17:00 h: Presentation and discussion of papers – Session 2
(3 papers: 15.45- 17.30h)


Thursday, February, 22nd
9:00-10.15 h: Lecture 7: Development and selection of T cells
António Bandeira

10.30-11.45 h: Lecture 8: Cellular mechanisms of autoimmunity
António Bandeira

14.00-15.15h: Lecture 9: New strategies for vaccine development
Anabela Cordeiro da Silva


Friday, February 23rd
9.00-10.15 h: Lecture 10: Cellular mechanisms of tolerance
António Bandeira

10.30-11.45 h: Presentation and discussion of papers – Session 3
(3 papers: 10.30-12.15)

15.45-17.00 h: Open seminar (16-17h):
“Inflammation in the pathogenesis of cardiovascular diseases: new pharmacological approaches”
Kai Zacharowski



Work Groups and Papers Presentation:

Ana Caldeira Burgeiro (burgeiro@cnc.cj.uc.pt)
Rui Mamede Cruz (Quiasmo@clix.pt)FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006 Jul 28;126(2):375-87.FOXP3 and NFAT: partners in tolerance.Cell. 2006 Jul 28;126(2):253-6. (artigo de apoio)


Ana Sofia Rodrigues (asjrodrigues@hotmail.com)
Alexandra Isabel Rosa (air@cnc.cj.uc.pt)
Daniel Farinha Nunes (dnunes@cnc.cj.uc.pt)
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med. 2006 Dec 25;203(13):2853-63.


Ana Raquel Soares (arsoares@cnc.cj.uc.pt)
M. João Canas dos Santos (mjfcs@hotmail.com)
Gil Pereira Costa (costagil@cnc.cj.uc.pt)
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6392-7.

Paulo Barracosa (pbarracosa@gmail.com)
Vanessa Matos (vnss_matos@yahoo.com)
Sara Maurício Sousa (scmsousa@cnc.cj.uc.pt) Leishmania cytosolic silent information regulatory protein 2 deacetylase induces murine B-cell differentiation and in vivo production of specific antibodies. Immunology. 2006 Dec;119(4):529-40.

Joana Margarida Gaspar (jmgaspar@cnc.cj.uc.pt)
Sofia Soares Grade (scgrade@cnc.cj.uc.pt)
Pedro Brito (pedrombrito@yahoo.com
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov;116(11):3015-25.
Fat uses a TOLL-road to connect inflammation and diabetes. Cell Metab. 2006 Dec;4(6):417-9. (artigo de apoio)


Pedro Manuel Branco (pbranco@cnc.uc.pt)
Raquel Vinhas (raquelvinhas@student.bioq.uc.pt)
Tiago Granja    (granja.tiago@gmail.com)
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11;441(7090):179-85.


Ana Isabel M. Gomes (anaisa.gomes@netcabo.pt)
Nélia Pinheiro  (neliajeronimo@hotmail.com)
Marina Lurdes B. Brito (marina@cnc.cj.uc.pt)
Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci. 2006 Dec 6;26(49):12826-37.


M. Raquel Providencio (raquelcoutobrito@gmail.com)
Joana Filipa Neves (joaneves@cnc.cj.uc.pt)
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14473-8.


Sara Domingues (saramsdomingues@hotmail.com)
Vera Cortez (veracortez@hotmail.com)
Vera Sofia Ribeiro (vera14@cnc.cj.uc.pt)
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med. 2007 Feb 5; [Epub ahead of print]
 
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