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Systems Neuroscience
 
February 5 - 9
Miguel Castelo-Branco
Doctoral Program in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology (CNC)

University of Coimbra, Portugal
Location: IBILI-Faculdade de Medicina, Auditório Principal
Organizer: Miguel Castelo-Branco

Visual Neuroscience Laboratory
IBILI-Faculdade de Medicina
Azinhaga de Santa Comba
3000-354 Coimbra Portugal
Phone 00 351 239480286
Fax  00 351 239480280
mcbranco@ibili.uc.pt
mcbranco@ci.uc.pt


Invited Faculty


Rainer Goebel
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University,
Post Office Box 616, 6200 MD Maastricht, Netherlands
R.Goebel@Psychology.Unimaas.Nl


Rui Costa
Section on In Vivo Neural Function,
Laboratory for Integrative Neuroscience
NIAAA/NIH
5625 Fishers Lane, Room TS-20D,MSC 9411
Bethesda, MD  20892-9411
Tel : (301) 443 1196
Fax : (301) 480 0466
e-mail : costarui@mail.nih.gov


Marta Moita
Gulbenkian Institute for Science
Oeiras, Portugal
moita@igc.gulbenkian.pt


Serge Picaud
INSERM U-592, Universite Pierre et Marie Curie-Paris6, Laboratoire de Physiopathologie
Cellulaire et Moleculaire de la Retine, F-75571 Paris, France. serge.picaud@st-antoine.inserm.fr


Main goals of the course
To study the relevance of in vivo models (animal and human) and quantitative approaches to understand neuronal function in health and disease. 


Day 1
Monday, 5th February 2007
9.15 am
Introductory notes
Miguel Castelo-Branco
Affiliation and contacts
Miguel Castelo-Branco
IBILI Faculdade de Medicina – Az. de Sta Comba, Celas 3000-354 Coimbra
tel  239 480286 ou 239 480220
telem 936360050 
fax 239 480280
mcbranco@ibili.uc.p
9.30 – 11.00 am - Lecture 1
Basic principles of organization of the visual system. From the retina to the cortex
Miguel Castelo-Branco
11.30 – 13.00 - Lecture 2
Photoreceptor degeneration : from single cell and multielectrode recordings to therapeutic strategies
Serge Picaud
Affiliation and contacts
INSERM U-592, Universite Pierre et Marie Curie-Paris6, Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, F-75571 Paris, France.
serge.picaud@st-antoine.inserm.fr
Afternoon
14h 30m
Challenges in choosing a lab and a PhD project within the scope of a Doctoral Program.

Discussion with Faculty members
Paper and group assignments for discussion.

Day 2
9.15 am – 10h 30 - Lecture 1
Does GABA excitatory transmission in the adult retina contribute to retinal physiopathology ?
Serge Picaud
10.45 am – 12h 05
Lecture 2Structure-Function relationships in the visual system. Implications for genotype-phenotype relationships in retinal and cortical disorders
Miguel Castelo-Branco

Afternoon
14.00 h

Paper presentations and discussion (Reference 1. from M. Castelo-Branco and References 1. & 2. from Serge Picaud). Three papers.
Day 3
9.15 am – 10h 45m - Lecture 1
Basic concepts in the cognitive Neuroscience of memory: the role of animal models
Rui Costa
Affiliation and contacts
Section on In Vivo Neural Function,
Laboratory for Integrative Neuroscience
NIAAA/NIH
5625 Fishers Lane, Room TS-20D,MSC 9411
Bethesda, MD  20892-9411
Tel : (301) 443 1196
Fax : (301) 480 0466
e-mail : costarui@mail.nih.gov
http://www.niaaa.nih.gov/ResearchInformation/IntramuralResearch/AboutDICBR/LIN/IVNF/default.htm
11h 15 am – 12h 45m - Lecture 2
Principles of Functional Brain Imaging
Rainer Goebel

Affiliation and contact
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, Post Office Box 616, 6200 MD Maastricht, Netherlands

Afternoon

14h30 – 16h00 - Lecture 2

Models in Human Cognitive Neuroscience
Rainer Goebel
16h-17h30
References from M. Castelo-Branco (Reference 2.; one paper)
Day 4
9h 15m – 10h 30 m - Lecture 1
Neural mechanisms underlying learning and memory: the role of striatal-cortical circuitsRui Costa
11h 00m – 12h 15m - Lecture 2
Neural mechanisms underlying learning and memory: the role of amydgala-hipocampal networks
Marta Moita
Affiliation and contacts
Gulbenkian Institute for Science
Oeiras, Portugal
moita@igc.gulbenkian.pt
Afternoon
14h30 – 17h30
Paper presentations and discussion (References 1. & 2.  from Rainer Goebel and Reference 1.  from Marta Moita). Three papers.

Day 5
Friday 9 th February 2007
9h30 – 12h00
Paper presentations and discussion (References 1. & 2.  from R. Costa and Reference 2. from M. Moita). Three papers.
 
16h00 - Seminar: References
Marta Moita
Neural mechanisms underlying associative plasticity during auditory fear conditioning

Rainer Goebel

Papers for discussion
1.
Kamitani Y & Tong F (2005). Decoding the visual and subjective contents of the human brain. Nature Neuroscience, 8, 679-685.
2. Haynes et al. (2005). Predicting the orientation of invisible stimuli from activity in human primary visual cortex. Nature Neuroscience, 8, 686-691

Review:
Haynes JD & Rees G (2006). Decoding mental states from brain activity in humans. Nature Reviews Neuroscience, 7, 523-534.
Other references
Formisano E, Kim DS, Di Salle F, van de Moortele PF, Ugurbil K, Goebel R. Mirror-symmetric tonotopic maps in human primary auditory cortex. Neuron. 2003 Nov 13;40(4):859-69.

Sack AT, Camprodon JA, Pascual-Leone A, Goebel R. The dynamics of interhemispheric compensatory processes in mental imagery. Science. 2005 Apr 29;308(5722):702-4.


Serge Picaud

Papers for discussion
1. Roska B, Werblin F. (2001) Vertical interactions across ten parallel, stacked representations in the mammalian retina. Nature, 410: 583-587.
2. Léveillard T, Mohand-Said S, Lorentz O, Hicks D, Fintz AC, Clerin E, Simonutti M, Forster V, Cavusoglu N, Chalmel F, Dolle P, Poch O, Lambrou G, Sahel JA. (2004) Identification and characterization of rod-derived cone viability factor. Nat. Genet. 36: 755-9
Other references
Vallazza-Deschamps G, Cia D, Gong J, Jellali A, Duboc A, Forster V, Sahel JA, Tessier LH, Picaud S. Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors. Eur J Neurosci. 2005 Sep;22(5):1013-22.
Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nature Medicine 1999 Oct;5(10):1183-7. 
Duboc A., Hanoteau N., Simonutti  M., Rudolf G., Nehlig A., Sahel J.A., Picaud S. Vigabatrin, the GABA-transaminase inhibitor, damaged cone photoreceptors in ratsAnnals of Neurology (2004) 55: 695-705.

Pattnaik B., Jellali A., Sahel J., Dreyfus H. and Picaud S. GABAC receptors are localized with protein MAP1B in mammalian cone photoreceptors.  J. Neurosci. (2000) 20: 6789-6796.
Cia D., Bordais A., Varela C., Forster V., Sahel J.A., Rendon A. and Picaud S. Voltage-gated channels and calcium homeostasis in mammalian rod photoreceptors. J. Neurophysiol. (2005) 93: 1468-1475.

Rui Costa
Papers for discussion
1. Cagniard B, Beeler JA, Britt JP, McGehee DS, Marinelli M, Zhuang X. Dopamine scales performance in the absence of new learning. Neuron. 2006 Sep 7;51(5):541-7.
2. Jackson A, Mavoori J, Fetz EE. Long-term motor cortex plasticity induced by an electronic neural implant. Nature. 2006 Nov 2;444(7115):56-60. Epub 2006 Oct 22. 
Other references
Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr, M., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52(2):359-69.

Costa, R.M., Cohen, D., Nicolelis M.A.L. (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Current Biology, 14(13):1124-34.
Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 2002 Jan 31;415(6871):526-30.


Marta Moita
Papers for discussion
1. Paton JJ, Belova MA, Morrison SE, Salzman CD.  The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature. 2006 Feb 16;439(7078):865-70.
2. Paz R, Pelletier JG, Bauer EP, Pare D. Emotional enhancement of memory viaamygdala-driven facilitation of rhinal interactions. Nat Neurosci. 2006 Oct;9(10):1321-9. Epub 2006 Sep 10.
Other references
Moita MA, Lamprecht R, Nader K, LeDoux JE. A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat Neurosci. 2002 Sep;5(9):837-8.
Moita MA, Rosis S, Zhou Y, LeDoux JE, Blair HT Putting fear in its place: remapping of hippocampal place cells during fear conditioning. J Neurosci. 2004 Aug 4;24(31):7015-23.
Moita MA, Rosis S, Zhou Y, LeDoux JE, Blair HT. Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. Neuron. 2003 Feb 6;37(3):485-97.

Miguel Castelo-Branco
Papers for discussion:
1. Brewer AA, Liu J, Wade AR, Wandell BA. Visual field maps and stimulus selectivity in human ventral occipital cortex. Nat Neurosci. 2005 Aug;8(8):1102-9.
Other references
M. F. Silva, P. Faria, F. Regateiro, V. Forjaz, C.Januário, A. Freire, and M. Castelo-Branco (2005) Relative patterns of damage within magno, parvo and koniocellular pathways in Parkinson´s disease. Brain Oct;128(Pt 10):2260-71
Biederlack J, Castelo-Branco M, Neuenschwander S, Wheeler DW, Singer W, Nikolic D. Brightness induction: rate enhancement and neuronal synchronization as complementary codes. Neuron. 2006; 52(6):1073-83.
Castelo-Branco, M.  Formisano, E.  Backes, W.  Zanella, F. Neuenschwander, S.,  Singer, W.  & Rainer Goebel (2002) Activity patterns in human motion sensitive areas depend on the interpretation of global motion Proceedings of Nacional Academy of Sciences, USA, 99(21): 13914-13919.
Castelo-Branco M., Goebel, R. Neuenschwander S., and Singer W. (2000) "Neural synchrony reflects surface segmentation rules." Nature405(6787):685-689.
 
Thursday 8 th February 2007
Wednesday, 7 th February 2007
Tuesday, 6th February 2007
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