Invited lecturers
Lloyd Greene (lag3@columbia.edu) Dept. of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
Alun Davies (daviesalun@Cardiff.ac.uk) Cardiff School of Biosciences, BIOSI 3, Museum Avenue, Cardiff CF 10 3US, UK
Leonidas Stefanis (lstefanis@bioacademy.gr) Laboratory of Biology of Neurodegenerative Diseases, Foundation for Biomedical Research of the Academy of Athens and University of Athens, Greece.
Course Schedule
Monday (Jan 15)
10:00 – 11:30 Molecular Mechanisms of Cell Death (I) Lloyd Greene
14:30 – 16:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (I) Alun Davies
Tuesday (Jan 16)
8:30 – 10:00 Molecular Mechanisms of Cell Death (II) Lloyd Greene
10:30 – 12:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (II) Alun Davies
14:30 Journal Club Discussion leader, Lloyd Greene
Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol. 8: 1348-1358 (2006). Students: Ana Burgeiro & Alexandra Rosa & Daniela Arduíno
Williams DW, Kondo S, Krzyzanowska A, Hiromi Y, Truman JW. Local caspase activity directs engulfment of dendrites during pruning. Nat Neurosci. 9: 1234-1236 (2006). Students: Ana Soares & Daniel Nunes[ Supplement reading 1 - Supplement reading 2 - Supplement reading 3]
Wednesday (Jan 17)
9:00 – 10:30 Cell Death in Neurodegenerative Disorders Leonidas Stefanis
11:00 – 12:30 Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Death Armanda Santos
14:30 Journal Club Discussion leader, Alun Davies
Thursday (Jan 18)
9:00 – 10:30 Autophagy and Neuron Cell Death Leonidas Stefanis
10:45 – 12:00 TNF superfamily: Effects on Neuron Development and Survival Alun Davies
14:30 Journal Club Discussion leader, Leonidas Stefanis
Friday (Jan 19)
9:00 – 10:00 The Role of Protein Scaffolds in JNK Signaling and Neuron death Lloyd Greene
10:30 – 12:00 General Discussion: Future directions in basic research and strategies to apply our knowledge to treatment/prevention of stroke, trauma and neurodegenerative disorders...................................Lloyd Greene
Future Reading [PDF]
Lecture Notes [Lloyd Greene] 16:00 – 17:00 Seminar: How do neurons die in neurodegenerative disorders and how can we prevent this? Insights from cellular models.
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