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Death and Survival Signaling
January 15 - 19
Armanda Santos, Emília Duarte e Paulo Santos

Course Sponsor: Biogen Idec
Invited lecturers
Lloyd Greene (lag3@columbia.edu)
Dept. of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
Alun Davies (daviesalun@Cardiff.ac.uk)
Cardiff School of Biosciences, BIOSI 3, Museum Avenue, Cardiff CF 10 3US, UK
Leonidas Stefanis (lstefanis@bioacademy.gr)
Laboratory of Biology of Neurodegenerative Diseases, Foundation for Biomedical Research of the Academy of Athens and University of Athens, Greece.

Course Schedule

Monday (Jan 15)
10:00 – 11:30 Molecular Mechanisms of Cell Death (I)
                      Lloyd Greene
14:30 – 16:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (I)
                      Alun Davies

Tuesday (Jan 16)
 8:30 – 10:00 Molecular Mechanisms of Cell Death (II)
                      Lloyd Greene
10:30 – 12:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (II)
                      Alun Davies
14:30 Journal Club
Discussion leader, Lloyd Greene
Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.  Nat Cell Biol. 8: 1348-1358 (2006).
Students: Ana Burgeiro & Alexandra Rosa & Daniela Arduíno

Williams DW, Kondo S, Krzyzanowska A, Hiromi Y, Truman JW. Local caspase activity directs engulfment of dendrites during pruning.  Nat Neurosci. 9: 1234-1236 (2006).
Students: Ana Soares & Daniel Nunes
[Supplement reading 1 - Supplement reading 2 - Supplement reading 3]

 Wednesday (Jan 17)
9:00 – 10:30 Cell Death in Neurodegenerative Disorders 
                    Leonidas Stefanis   
11:00 – 12:30 Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Death
                      Armanda Santos
14:30 Journal Club
Discussion leader, Alun Davies
Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD. (2004).  A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.  Cell 118(2): 243-255.
Students: Gil Costa & Joana Neves
Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. (2006). Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50(2): 219-232.        
Students: Joana Gaspar & Sofia Grade
[Suppement reading 1]

Thursday (Jan 18)
9:00 – 10:30 Autophagy and Neuron Cell Death     
                    Leonidas Stefanis   
10:45 – 12:00 TNF superfamily: Effects on Neuron Development and Survival
                      Alun Davies
14:30 Journal Club
Discussion leader, Leonidas Stefanis
Komatsu M, Waguri S, Chiba S, et al., Loss of autophagy in the central nervous system causes neurodegeneration in mice  Nature 441:880-884 (2006). 
Students: Pedro Branco & Vera Ribeiro
[Supplement reading 1]
Paola Sgadò, Lavinia Albéri, Daniel Gherbassi, et al., Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice PNAS 103: 15242-15247 (2006)
Students: Ana Raquel Esteves & Rui Costa

Friday (Jan 19)
9:00 – 10:00 The Role of Protein Scaffolds in JNK Signaling and Neuron death     
                    Lloyd Greene
10:30 – 12:00 General Discussion: Future directions in basic research and strategies to apply our knowledge to treatment/prevention of stroke, trauma and neurodegenerative disorders...................................Lloyd Greene

Future Reading


Lecture Notes

[Lloyd Greene]

16:00 – 17:00 Seminar: How do neurons die in neurodegenerative disorders and how can we prevent this? Insights from cellular models.
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