Invited lecturers

Lloyd Greene (lag3@columbia.edu)
Dept. of Pathology, Columbia University Medical Center, New York, New York 10032, USA.

Alun Davies (daviesalun@Cardiff.ac.uk)
Cardiff School of Biosciences, BIOSI 3, Museum Avenue, Cardiff CF 10 3US, UK

Leonidas Stefanis (lstefanis@bioacademy.gr)
Laboratory of Biology of Neurodegenerative Diseases, Foundation for Biomedical Research of the Academy of Athens and University of Athens, Greece.

10:00 – 11:30 Molecular Mechanisms of Cell Death (I)
                      Lloyd Greene

14:30 – 16:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (I)
                      Alun Davies

 8:30 – 10:00 Molecular Mechanisms of Cell Death (II)
                      Lloyd Greene

10:30 – 12:00 Developmental Neuronal Cell Death and Its Regulation by .....................Neurotrophic factors (II)
                      Alun Davies

14:30 Journal Club
Discussion leader, Lloyd Greene

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.  Nat Cell Biol. 8: 1348-1358 (2006).
Students: Ana Burgeiro & Alexandra Rosa & Daniela Arduíno

Williams DW, Kondo S, Krzyzanowska A, Hiromi Y, Truman JW. Local caspase activity directs engulfment of dendrites during pruning.  Nat Neurosci. 9: 1234-1236 (2006).
Students: Ana Soares & Daniel Nunes
[Supplement reading 1 - Supplement reading 2 - Supplement reading 3]

9:00 – 10:30 Cell Death in Neurodegenerative Disorders 
                    Leonidas Stefanis   

11:00 – 12:30 Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Death
                      Armanda Santos

14:30 Journal Club
Discussion leader, Alun Davies

Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD. (2004).  A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.  Cell 118(2): 243-255.
Students: Gil Costa & Joana Neves

Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. (2006). Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 50(2): 219-232.        
Students: Joana Gaspar & Sofia Grade
[Suppement reading 1]

Arevalo JC, Waite J, Rajagopal R, Beyna M, Chen ZY, Lee FS, Chao MV. (2006).  Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50(4): 549-559.
Students: Marina Brito & Rita Santos
[Supplement reading 1]

9:00 – 10:30 Autophagy and Neuron Cell Death     
                    Leonidas Stefanis   

10:45 – 12:00 TNF superfamily: Effects on Neuron Development and Survival
                      Alun Davies

14:30 Journal Club
Discussion leader, Leonidas Stefanis

Komatsu M, Waguri S, Chiba S, et al., Loss of autophagy in the central nervous system causes neurodegeneration in mice  Nature 441:880-884 (2006). 
Students: Pedro Branco & Vera Ribeiro
[Supplement reading 1]

Hara T, Nakamura K, Matsui M, et al., Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 441(7095):885-9 (2006)
Students: Sara Sousa & Marta Vieira
[Supplement reading 1 - Supplement reading 2]

Paola Sgadò, Lavinia Albéri, Daniel Gherbassi, et al., Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice PNAS 103: 15242-15247 (2006)
Students: Ana Raquel Esteves & Rui Costa

9:00 – 10:00 The Role of Protein Scaffolds in JNK Signaling and Neuron death     
                    Lloyd Greene

10:30 – 12:00 General Discussion: Future directions in basic research and strategies to apply our knowledge to treatment/prevention of stroke, trauma and neurodegenerative disorders...................................Lloyd Greene


Future Reading
[PDF]


Lecture Notes
[Lloyd Greene]
16:00 – 17:00 Seminar: How do neurons die in neurodegenerative disorders and how can we prevent this? Insights from cellular models.