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Development Biology
 
December 4 - 7
Pedro Domingos
Course for the PhD program in experimental biology and biomedicine
University of Coimbra, December 4th to 7th 2006 - Conference Room IBILI
Organizer: Pedro Domingos
Developmental Biology studies the molecular and cellular interactions that occur in a developing embryo and integrates many areas of biology, such as molecular and cellular biology, embryology, physiology, genetics and evolutionary biology. This course will focus on a few topics of this broad area, highlighting several biological systems (flies, frogs, zebrafish, chicks and mice), which are used to address different biological questions. The course consists of talks/seminars and 3 journal clubs.
 
Schedule

 
Monday
(12/04)
Tuesday
(12/05)
Wednesday
(12/06)
Thursday
(12/07)
10:00-11:00
Pedro Domingos
Drosophila
Journal club
Ze-To Belo
Guillermina
Lopez Bendito
11:00-12:00
Rui Martinho
Drosophila Journal Club
(3 papers)
Moises Mallo
Journal club preparation
lunch
...
...
...
...
14:00-15:00
Antonio
Jacinto
Josh Brickman
Vertebrate Journal Club
(5 papers)
Axon Guidance Journal Club (2 papers)
15:00-16:00
Drosophila
Journal club (2 papers)
Leonor Saude
Vertebrate Journal Club
Axon Guidance Journal Club
16:00-17:00
Drosophila
Journal club
Journal club preparation
Vertebrate Journal Club
Conclusions/Evaluation

 
Drosophila Journal Club – Pedro Domingos, Rui Martinho, Antonio Jacinto
 
1) Pilot F, Philippe JM, Lemmers C, Lecuit T. (2006) Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature. Aug 3;442(7102):580-4.
2) Blankenship JT, Backovic ST, Sanny JS, Weitz O, Zallen JA. (2006) Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. Oct;11(4):459-70.
3) Wernet MF, Mazzoni EO, Celik A, Duncan DM, Duncan I, Desplan C. (2006) Stochastic spineless expression creates the retinal mosaic for colour vision. Nature. Mar 9;440(7081):174-80
4) Moreno E, Basler K. (2004) Myc transforms cells into super-competitors. Cell. Apr 2;117(1):117-29.
5) Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006 Sep 19;16(18):1835-43. - [sup. data]


Vertebrate Journal Club – Josh Brickman, Moises Mallo, Pedro Domingos
1) Takahashi K, Yamanaka S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. Aug 25;126(4):663-76.
2) Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S. (2005) Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell. Apr 8;121(1):87-99.
3) Kmita M, Tarchini B, Zakany J, Logan M, Tabin CJ, Duboule D. Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature. 2005 Jun 23;435(7045):1113-6.
4) Nonaka S, Shiratori H, Saijoh Y, Hamada H. 2002 Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. Jul 4;418(6893):96-9.
5) Fletcher RB, Baker JC, Harland RM (2006) FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus. Development. 2006 May;133(9):1703-14


Axon Guidance Journal Club – Guillermina Lopez-Bendito
Check pdf file for each article and word file with web-pages for supplementary materials (movies, figures, etc). Requires access to Nature, Developmental Cell, Cell, Neuron.


Faculty


Talk Title: Cell specification and differentiation in the Drosophila eye.


Rui Martinho, Ph.D.
Email: rmartinho@igc.gulbenkian.pt
Instituto Gulbenkian de Ciência/Faculdade de Medicina de Lisboa
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Establishment of a polarized epithelium during Drosophila  melanogaster early embryonic development


Antonio Jacinto, Ph.D.
Email: ajacinto@fm.ul.pt
Instituto de Medicina Molecular
Edificio Egas Moniz, Av Prof Egas Moniz, 1649-028 Lisboa, Portugal
Talk Title: Epithelial morphogenesis
References:
Simoes, S., Denholm, B., Azevedo, D., Sotillos, S., Martin, P.,  Skaer, H., Castelli-Gair Hombria, J. and Jacinto, A. (2006).  Compartmentalization of Rho regulators directs cell invagination  during tissue morphogenesis. Development 133, 4257-4267.


Josh Brickman, Ph.D.
Email: josh.brickman@ed.ac.uk
Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Scotland.
Talk Title: Teaching an old frog new tricks -- lesions learned about embryonic stem cells from Xenopus gastrulation.


Leonor Saude, Ph.D.
Email: mlsaude@igc.gulbenkian.pt
Instituto Gulbenkian de Ciência/Faculdade de Medicina de Lisboa
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Asymmetrical on the inside, Symmetrical on the outside
References;
Saúde L., Lourenço R., Gonçalves A. and Palmeirim I.  terra Nature Cell BiologyAxis-inducing activities and cell fates of the zebrafish organizer.  Development (2000) Vol. 127 (16), 3407-17 (2005) Vol.7(9), 918-20

Saúde L., Woolley K., Martin P., Driever W. and Stemple D. L. 
is a left-right asymmetry gene required for left-right synchronization of the segmentation clock.
José António Belo, Ph.D.
Email: jbelo@ualg.pt
IBB-Institute for Biotechnology and Bioengineering,
CBME / FERN, Universidade do Algarve. Campus de Gambelas, 8005-139 Faro.
PORTUGAL; and Instituto Gulbenkian de Ciência, Oeiras, PORTUGAL.
Talk Title: Constructing the vertebrate embryo: the role of the cerberus-like gene family.
 
References:
Silva, A., Filipe, M., Kuerner, K., Steinbeisser, H. and Belo, J.A. (2003). Endogenous Cerberus activity is required for anterior head induction in Xenopus. Development 130, 4943-4953.
Sara Marques, Ana C. Borges, Ana C. Silva, Sandra Freitas, Michelangelo Cordenonsi & José A. Belo (2004). The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes & Dev 18, 2342-2347.
Chiharu Kimura-Yoshida, Hiroshi Nakano, Daiji Okamura, Kazuki Nakao, Shigenobu Yonemura, José A. Belo, Shinichi Aizawa, Yasuhisa Matsui and Isao Matsuo (2005). Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev. Cell. 9, 639-650.


Moises Mallo, Ph.D.
Email: mallo@igc.gulbenkian.pt
Instituto Gulbenkian de Ciencia,
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Hox genes are breathing again
References:
Bobola, N., Carapuço, M., Ohnemus, S., Kanzler, B., Leibbrandt, A., Neubüser, A, Drouin, J. & Mallo, M. (2003). Mesenchymal patterning by Hoxa2 requires blocking FGF-dependent activation of Ptx1. Development 130:3403-3414.


Guillermina López-Bendito, Ph.D.
Email: g.lbendito@umh.es
Instituto de Neurociencias
CSIC-Universidad Miguel Hernández, Campus de San Juan,
03550 San Juan de Alicante, Spain
Talk Title: Mechanisms of Axon Guidance: How to get to the right place
References:
Lopez-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garratt AN, Talmage DA, Role LW, Charnay P, Marin O, Garel S. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006 Apr 7;125(1):127-42.
Web-pages with supplementary materials for each paper of journal clubs
Nature, Developmental Cell, Cell, Neuron


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