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Development Biology
December 4 - 7
Pedro Domingos
Course for the PhD program in experimental biology and biomedicine
University of Coimbra, December 4th to 7th 2006 - Conference Room IBILI
Organizer: Pedro Domingos
Developmental Biology studies the molecular and cellular interactions that occur in a developing embryo and integrates many areas of biology, such as molecular and cellular biology, embryology, physiology, genetics and evolutionary biology. This course will focus on a few topics of this broad area, highlighting several biological systems (flies, frogs, zebrafish, chicks and mice), which are used to address different biological questions. The course consists of talks/seminars and 3 journal clubs.

Pedro Domingos
Journal club
Ze-To Belo
Lopez Bendito
Rui Martinho
Drosophila Journal Club
(3 papers)
Moises Mallo
Journal club preparation
Josh Brickman
Vertebrate Journal Club
(5 papers)
Axon Guidance Journal Club (2 papers)
Journal club (2 papers)
Leonor Saude
Vertebrate Journal Club
Axon Guidance Journal Club
Journal club
Journal club preparation
Vertebrate Journal Club

Drosophila Journal Club – Pedro Domingos, Rui Martinho, Antonio Jacinto
1) Pilot F, Philippe JM, Lemmers C, Lecuit T. (2006) Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature. Aug 3;442(7102):580-4.
2) Blankenship JT, Backovic ST, Sanny JS, Weitz O, Zallen JA. (2006) Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. Oct;11(4):459-70.
3) Wernet MF, Mazzoni EO, Celik A, Duncan DM, Duncan I, Desplan C. (2006) Stochastic spineless expression creates the retinal mosaic for colour vision. Nature. Mar 9;440(7081):174-80
4) Moreno E, Basler K. (2004) Myc transforms cells into super-competitors. Cell. Apr 2;117(1):117-29.
5) Hiesinger PR, Zhai RG, Zhou Y, Koh TW, Mehta SQ, Schulze KL, Cao Y, Verstreken P, Clandinin TR, Fischbach KF, Meinertzhagen IA, Bellen HJ. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006 Sep 19;16(18):1835-43. - [sup. data]

Vertebrate Journal Club – Josh Brickman, Moises Mallo, Pedro Domingos
1) Takahashi K, Yamanaka S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. Aug 25;126(4):663-76.
2) Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S. (2005) Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell. Apr 8;121(1):87-99.
3) Kmita M, Tarchini B, Zakany J, Logan M, Tabin CJ, Duboule D. Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature. 2005 Jun 23;435(7045):1113-6.
4) Nonaka S, Shiratori H, Saijoh Y, Hamada H. 2002 Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. Jul 4;418(6893):96-9.
5) Fletcher RB, Baker JC, Harland RM (2006) FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus. Development. 2006 May;133(9):1703-14

Axon Guidance Journal Club – Guillermina Lopez-Bendito
Check pdf file for each article and word file with web-pages for supplementary materials (movies, figures, etc). Requires access to Nature, Developmental Cell, Cell, Neuron.


Talk Title: Cell specification and differentiation in the Drosophila eye.

Rui Martinho, Ph.D.
Email: rmartinho@igc.gulbenkian.pt
Instituto Gulbenkian de Ciência/Faculdade de Medicina de Lisboa
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Establishment of a polarized epithelium during Drosophila  melanogaster early embryonic development

Antonio Jacinto, Ph.D.
Email: ajacinto@fm.ul.pt
Instituto de Medicina Molecular
Edificio Egas Moniz, Av Prof Egas Moniz, 1649-028 Lisboa, Portugal
Talk Title: Epithelial morphogenesis
Simoes, S., Denholm, B., Azevedo, D., Sotillos, S., Martin, P.,  Skaer, H., Castelli-Gair Hombria, J. and Jacinto, A. (2006).  Compartmentalization of Rho regulators directs cell invagination  during tissue morphogenesis. Development 133, 4257-4267.

Josh Brickman, Ph.D.
Email: josh.brickman@ed.ac.uk
Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Scotland.
Talk Title: Teaching an old frog new tricks -- lesions learned about embryonic stem cells from Xenopus gastrulation.

Leonor Saude, Ph.D.
Email: mlsaude@igc.gulbenkian.pt
Instituto Gulbenkian de Ciência/Faculdade de Medicina de Lisboa
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Asymmetrical on the inside, Symmetrical on the outside
Saúde L., Lourenço R., Gonçalves A. and Palmeirim I.  terra Nature Cell BiologyAxis-inducing activities and cell fates of the zebrafish organizer.  Development (2000) Vol. 127 (16), 3407-17 (2005) Vol.7(9), 918-20

Saúde L., Woolley K., Martin P., Driever W. and Stemple D. L. 
is a left-right asymmetry gene required for left-right synchronization of the segmentation clock.
José António Belo, Ph.D.
Email: jbelo@ualg.pt
IBB-Institute for Biotechnology and Bioengineering,
CBME / FERN, Universidade do Algarve. Campus de Gambelas, 8005-139 Faro.
PORTUGAL; and Instituto Gulbenkian de Ciência, Oeiras, PORTUGAL.
Talk Title: Constructing the vertebrate embryo: the role of the cerberus-like gene family.
Silva, A., Filipe, M., Kuerner, K., Steinbeisser, H. and Belo, J.A. (2003). Endogenous Cerberus activity is required for anterior head induction in Xenopus. Development 130, 4943-4953.
Sara Marques, Ana C. Borges, Ana C. Silva, Sandra Freitas, Michelangelo Cordenonsi & José A. Belo (2004). The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes & Dev 18, 2342-2347.
Chiharu Kimura-Yoshida, Hiroshi Nakano, Daiji Okamura, Kazuki Nakao, Shigenobu Yonemura, José A. Belo, Shinichi Aizawa, Yasuhisa Matsui and Isao Matsuo (2005). Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev. Cell. 9, 639-650.

Moises Mallo, Ph.D.
Email: mallo@igc.gulbenkian.pt
Instituto Gulbenkian de Ciencia,
Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
Talk Title: Hox genes are breathing again
Bobola, N., Carapuço, M., Ohnemus, S., Kanzler, B., Leibbrandt, A., Neubüser, A, Drouin, J. & Mallo, M. (2003). Mesenchymal patterning by Hoxa2 requires blocking FGF-dependent activation of Ptx1. Development 130:3403-3414.

Guillermina López-Bendito, Ph.D.
Email: g.lbendito@umh.es
Instituto de Neurociencias
CSIC-Universidad Miguel Hernández, Campus de San Juan,
03550 San Juan de Alicante, Spain
Talk Title: Mechanisms of Axon Guidance: How to get to the right place
Lopez-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garratt AN, Talmage DA, Role LW, Charnay P, Marin O, Garel S. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006 Apr 7;125(1):127-42.
Web-pages with supplementary materials for each paper of journal clubs
Nature, Developmental Cell, Cell, Neuron

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