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Synapse, Circuitry and Behavior
 
March 3 - 7
Chinfei Chen, Guoping Feng
LECTURERS:

Chinfei Chen, MD, PhD
Children´s Hospital, Boston
Harvard Medical School
300 Longwood Avenue
Boston, MA 02115

Guoping Feng, PhD

Department of Neurobiology
Duke University Medical Center
Durham, NC 27710

Valerie Ego-Stengel, PhD
Unité de Neurosciences Intégratives et Computationnelles
Institut de Neurobiologie Alfred Fessard, CNRS
Bât. 33, 1 Ave de la Terrasse
91 198 Gif sur Yvette Cedex, France

Catia Feliciano
Department of Neurobiology
Duke University Medical Center
Durham, NC 27710

Gulbenkian PhD Programme in Biomedicine
Gulbenkian Science Institute, Portugal.

Joao Peca
Department of Neurobiology
Duke University Medical Center
Durham, NC 27710

Center for Neuroscience and Cell Biology
University of Coimbra
Coimbra, Portugal


COURSE SCHEDULE:

Monday, March 3
9h-10.15h: Neural circuitry and function of the thalamus
Chinfei Chen

10.30h-11.45h: Short-term and Long-term Forms of Synaptic Plasticity
Chinfei Chen
14-17h: Research Roundtable.
Chinfei Chen and Guoping Feng

Background reading
Review on thalamus: Sherman and Guillery
Review on Short-term plasticity:  Blitz, Foster and Regehr


Tuesday, March 4
9h-10.15h: Neural circuitry and function of the basal ganglia (I)
Guoping Feng

10.30h-11.45h: Neural circuitry and function of the basal ganglia (II)
Guoping Feng
14-17h: Presentation, discussion and critique of original research papers.
Chinfei Chen[PDF 1] - [PDF 2]

Discussion of original research papers
Brenowitz and Trussell
Kawai, Lazar and Metherate

Wednesday, March 5
9h-10.15h: Manipulations of the mouse genome (I)
Catia Feliciano


10.30h-11.45h: Manipulations of the mouse genome (II)
Joao Peca

Pdf morning sessions [PDF 1] - [PDF 2]
14-16h: Presentation, discussion and critique of original research papers.
Guoping Feng[PDF 1] - [PDF 2]

Thursday, March 6
9h-10.15h: Hippocampal circuitry and function (I)
Valerie Ego-Stengel


10.30h-11.45h: Hippocampal circuitry and function (II).
Valerie Ego-Stengel
14-17h: Presentation, discussion and critiques of original research papers.
Valerie Ego-Stengel


Morning session
Background material (reviews):

Leutgeb S, Leutgeb JK, Moser MB, Moser EI.
Place cells, spatial maps and the population code for memory.
Curr Opin Neurobiol. 2005 Dec;15(6):738-46.

Nakazawa K, McHugh TJ, Wilson MA, Tonegawa S.
NMDA receptors, place cells and hippocampal spatial memory.
Nat Rev Neurosci. 2004 May;5(5):361-72.


Afternoon paper discussion:

*Article 1:*
Foster DJ, Wilson MA.
Reverse replay of behavioural sequences in hippocampal place cells
during the awake state.

Nature. 2006 Mar 30;440(7084):680-3.
[Legends] - [Figures]

*Article 2:*
Wills TJ, Lever C, Cacucci F, Burgess N, O´Keefe J.
Attractor dynamics in the hippocampal representation of the local
environment.

Science. 2005 May 6;308(5723):873-6.
[Supplement]


Friday, March 7
9h-12h: Cutting-edge tools for neuroscience research (I)
Guoping Feng, Chinfei Chen, Valerie Ego-Stengel
16h: CNC Seminar
Synaptic and Circuitry Mechanisms of Obsessive-Compulsive Disorder-like Behavior in Mice[PDF]

Optional reading on tools to trace synaptic circuits
Callaway_synaptic tracing
Svoboda and Yasuda, 2PE
Guoping Feng

Journal Club

Tuesday, March 4
“Enhancement of Synaptic Efficacy by Presynaptic GABAB Receptors”
Stephan Brenowitz, Jeannie David, and Laurence Trussell
Students: Joana Marinho; Gil Cunha
“Nicotinic control of axon excitability regulates thalamocortical transmission”
Hideki Kawai, Ronit Lazar & Raju Metherate
Students: Filipe Leal; Manuel Barroso
 
Wednesday, March 5
“Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice”
Welch et al
Students: Sara Figueiredo; João Santos
“Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models”
Day et al
Students: Ana Cabral; Ana Azevedo
 
Thursday, March 6
“Reverse replay of behavioural sequences in hippocampal place cells during the awake state”
Foster DJ, Wilson MA.
Students: Susana Louros; Nélio Gonçalves
“Attractor dynamics in the hippocampal representation of the local environment”
Wills TJ, Lever C, Cacucci F, Burgess N, O´Keefe J.
Students: Lígia Silva; Sueli Marques
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