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Immunology
 
February 11 - 15
Anabela C. Silva, M. Celeste Lopes, Sukalyan Chatterjee
Place: CNC Seminar Room/Anfiteatro de Farmacologia (Faculdade de Medicina da Universidade de Coimbra- Pólo I, 1º Andar)

Invited Lecturers:
Maria do Carmo Leite-de-Moraes
CNRS, Faculté de Médecine
René Descartes, Paris V, Hôpital Necker, Paris, France. Email : leite@necker.fr
Helena Soares
Steinman Lab, Bronk Building, Rockefeller University, USA.
Email: Pasteur Institute in Paris. hsoares@paster.fr
Gil Castro
Escola da Ciências de Saúde, Universidade do Minho.
Email: acastro@ecsaude.uminho.pt
Iris Caramalho
Instituto Gulbenkian de Ciências. Lymphocyte activation Group, Oeiras. Email: icarama@igc.gulbenkian.pt
Paula Maria Ferreira da Silva
Instituto de Ciências Biomédicas Abel Salazar e Instituto de Biologia Celular e Molecular, Universidade do Porto. Email: pauferr@icbas.up.pt
Anabela Cordeiro da Silva
Instituto de Biologia Celular e Molecular e Faculdade de Farmácia, Universidade do Porto. cordeiro@ibmc.up.pt.
Ricardo Silvestre
Instituto de Biologia Celular e Molecular e Faculdade de Farmácia, Universidade do Porto. rleal@ibmc.up.pt.

COURSE SCHEDULE
Monday (Fev. 11)10:00-11:00 – Introduction to basic aspects of immunology (Gil Castro)
11:00 – Coffee break
11:30-12:30 – The role of B cell in the immune response (Paula Ferreira)
12:30 – Lunch
14:00-15:00 - Th17 cells: a new era in immunology (Gil Castro)
15:00 – Coffee break
15:30 – Journal Club
Team A

Tuesday (Fev. 12)10:00 – Modulation of the immune system to protect against intracellular pathogens (Anabela Cordeiro da Silva and Ricardo Silvestre)
11:00 – Coffee break
11:30-12:30 – B cells controlling immune response (Paula Ferreira)
12:30 – Lunch
14:00 – Journal Club
Team B and Team C

Wednesday (Fev 13)10:00 – The role of regulatory T cells in the control of immune reactions (Iris Caramalho)
11:00 – Coffee break
11:30-12:30 – Regulatory T cells maintain effector cells at check in NOD mice protected from Diabetes by LPS treatment (Iris Caramalho)
12:30 – Lunch
14:00 – Journal Club
Team D

Thursday (Fev. 14)10:00 – The immunobiology of dendritic cells (Helena Soares)
11:00 – Coffee break
11:30-13:00 – Dendritic cells in cancer treatment (Helena Soares)
13:00 – Lunch
15:00 – Journal Club
Team E
17:00 – The immunoregulatory roles of invariant Natural Killer T cells (Maria do Carmo Leite)

Friday (Fev. 15)9:00 – Journal Club
Team F
11:30 – Seminar – "Role of invariant Natural Killer T cells in airway inflammations: foccus on allergic asthma."
Maria do Carmo Leite-de-Moraes

Group Students and PDFs

Team A:
Sara Figueiredo (Bioq., Coimbra)
Susana Louros (Biol., Coimbra)
Presentation papers
A1. The Journal of Immunology, From Tolerance to Autoimmunity: Is There a Risk in Early Life Vaccination? J. Comp. Path. 2007, Vol.137, 57-61. 2006, 177: 1416–1420.
A2. S. Goriely and M. Goldman . Andrea Cruz, Shabaana A. Khader, Egidio Torrado, Alexandra Fraga, John E. Pearl, Jorge Pedrosa, Andrea M. Cooper and António G. Castro. Cutting  Regulates the Induction and Expansion of IL-17-Producing CD4 T CellsgEdge: IFN- during Mycobacterial Infection.
 
Team B:
Lígia Silva (Farm., Coimbra)
Manuel Barroso (Bioq., Porto)
Presentation papers
B1. The Journal of Immunology, Central memory T cells mediate long term immunity to Leis mania major in absence of persistent parasite. Nature Medicine, 2004, Volume10,number 10, October. 2007, 179:3161–3170.
B2. Colby Zaph, Jude Uzonna, Setephan Bverly and Phillip Scott. Ricardo Silvestre, Anabela Cordeiro-Da-Silva, Nuno Santarem, Baptiste Vergnes, Denis Sereno and Ali Ouaissi. SIR2-Deficient Leishmania infantumgInduces a Defined IFN-  Correlates with Protection Protection /IL-10 Pattern That
 
Team C:
Ana Sofia Azevedo (Bioq., Coimbra)
Filipe Sousa Leal (Quim., Lx)
Presentation papers
C1. The Journal of Immunology2Regulation of Memory Antibody Levels: The Role of Persisting Antigen versus Plasma Cell Life Span. The Journal of Immunology, 2007, 178: 67–76., 2007, 178: 1379–1387.
C2. Dominique Gatto, Stephen W. Martin, Juliana Bessa, Erica Pellicioli, Philippe Saudan, Heather J. Hinton, and Martin F. BachmannPedro Madureira, Marina Baptista, Marta Vieira, Vanessa Magalhães, Ana Camelo, Liliana Oliveira, Adília Ribeiro, Delfina Tavares, Patrick Trieu-Cuot, Manuel Vilanova and Paula Ferreira. Streptococcus agalactiae GAPDH Is a Virulence-Associated Immunomodulatory Protein.
 
Team D:
Sueli Marques (Bioq., Coimbra)
Nélio Gonçalves (Farm., Coimbra)
Presentation papers
D1. A Two-Step-Process for Thymic Regulatory T Cell Development.  Immunity, January 2008, 28, 100–111.
D2. Jeong M Kim, Jeffrey P Rasmussen & Alexander Y Rudensky. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature Immunology. Feb. 2007, Vol. 8 Nº. 2 Chan-Wang Joaquim Lio Lio and Chyi-Song Hsieh Hsieh.
Consulting papers
D3. Kingston H. G.Mills. Regulatory T cells friend or foe in immunity to infection? Nature Review  Immunology, Nov. 2004, vol. 4.
 
Team E:
Ana Sofia Cabral (Bioq., Porto)
João Noutel (Bioq., Coimbra)
Presentation papers
E1.Visualizing dendritic cell networks in vivo. Nature Immunology, Dec. 2004, Vol. 5, Nº 12
E2. Caetano Reis e Sousa. Activation of dendritic cells: translating innate into adaptive immunity. Current Opinion in Immunology, 2004, 16:21–25.Randall L Lindquist, Guy Shakhar, Diana Dudziak, Hedda Wardemann, Thomas Eisenreich, Michael L Dustin & Michel C Nussenzweig.
Consulting papers
E3. Dendritic cell subsets in health and disease. Immunological Reviews, 2007, Vol. 219: 118–142.
E4. Jacques Banchereau and A. Karolina Palucka. Dendritic cells as therapeutic vaccines against cancer. Nature Review Immunology, 296, April 2005, vol. 5.
E5. Ralph M. Steinman & Jacques Banchereau. Taking dendritic cells into medicine. Nature. September 2007, Vol 449, 27.
E6. Bali Pulendran, Karolina Palucka, Jacques Banchereau. Sensing Pathogens and Tuning Immune Responses. Science, July 2001, Vol. 293, 13.Hideki Ueno, Eynav Klechevsky, Rimpei Morita, Caroline Aspord, Tinghua Cão, Toshimichi Matsui, Tiziana Di Pucchio, John Connolly, Joseph W. Fay, Virginia Pascual, A. Karolina Palucka, Jacques Banchereau.
 
Team F:
Gil Cunha (Med., Coimbra)
Joana Marinho (Bioq., Porto)
Presentation papers
F1.Omid Akbari, John L. Faul, Elisabeth G. Hoyte, Gerald J. Berry, Jan Wahlström,
Mitchell Kronenberg, Rosemarie H. DeKruyff and Dale T. Umetsu. CD4+ Invariant T-Cell Receptor+ Natural Killer T Cells in Bronchial Asthma. The New England Journal of Medicine, 2006, established in 1812 march 16, vol. 354 no. 11.
F2. Patricia Hachem, Mariette Lisbonne, Marie-Laure Michel, Siverine Diem, Sukit Roongapinun, Jean Lefort, Gilles Marchal, André Herbelin, Philip W. Askenase, Michel Dy and Maria C. Leite-de-Moraes. a-Galactosylceramide-induced iNKT cells suppress experimental .gallergic asthma in sensitized mice: Role of IFN- Eur. J. Immunol. 2005. 35: 2793–2802.
Consulting papers
F3. The Biology of NKT Cells. Annu. Rev. Immunol.2007.25:297-336.
F4. Mariette Lisbonne, Severine Diem, Alexandre de Castro Keller, Jean Lefort, Luiza M. Araujo, Patricia Hachem, Jean-Marie Fourneau, Stephane Sidobre, Mitchell Kronenberg, Masuru Taniguchi, Peter Van Endert, Dy, Philip Askenase, Momtchilo Russo, B. Boris Vargaftig, Andre Herbelin and Maria C. Leite-de-Moraes. 14 NKT Cells Are Required forbCutting Edge: Invariant V Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model. The Journal of Immunology, 2003, 171: 1637–1641.
F5. Pandurangan Vijayanand, Grégory Seumois, Chris Pickard, Robert M. Powell, Gilbert Angco, David Sammut, Stephan D. Gadola, Peter S. Friedmann and Ratko Djukanović. Invariant Natural Killer T Cells in Asthma and Chronic Obstructive Pulmonary Disease. N Engl J Med, 2007; 356:1410-22.
F6. Nhan Pham-Thi, Jacques de Blic, Muriel Le Bourgeois, Michel Dy, Pierre Scheinmann, Maria C. Leite-de-Moraes. Enhanced frequency of immunoregulatory invariant natural killer T cells in the airways of children with asthma. J Allergy Clin Immunol. Vol. 117, Nº 1 Letters to the Editor 217.
F7. Marie-Laure Michel, Alexandre Castro Keller, Christophe Paget, Masakazu Fujio, François Trottein, Paul B. Savage, Chi-Huey Wong, Elke Schneider, Michel Dy, and Maria C. Leite-de-Moraes. Identifi cation of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia. JEM,. 2007, Vol. 204, No. 5, May 14, 995–1001.Albert Bendelac, Paul B. Savage and Luc Teyton.
 
Coordinators:
Anabela Cordeiro da Silva (Faculdade Farmácia, U.P., IBMC, cordeiro@ibmc.up.pt),
Maria Celeste Lopes (CNCBC, U.C., mcflopes@ibili.uc.pt)
Sukalyan Chatterjee (CNCBC, U.C., sukalyan@igc.gulbenkian.pt)
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