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CNC Research
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Molecular Neuroscience
January 14 - 18
Ana Luisa Carvalho

Auditório do IBILI - Pólo III


Ann Marie Craig
Brain Research Centre
Department of Psychiatry, University of British Columbia
Vancouver, BC, Canada

Rachel Wong
Department of Biological Structure
University of Washington
Seattle, WA, USA

Susana Correia
Department of Pharmacology
University of Michigan Medical School, Ann Arbor, MI, USA

Ana Luisa Carvalho
Center for Neuroscience and Cell Biology & Department of Zoology
University of Coimbra
Coimbra, Portugal

Carlos B. Duarte
Center for Neuroscience and Cell Biology &Department of Zoology
University of Coimbra
Coimbra, Portugal


Monday, January 14
9h-10.15h: Axon Pathfinding and Formation of Topographic Maps in Sensory Systems
Rachel Wong
10.30h-11.45h: Experience-Dependent and Independent Patterning of Connections during Development (I).
Rachel Wong
14-15.15h: Introduction to Synapses: Structure-Function and Molecular Composition
Ann Marie Craig

Tuesday, January 15
9h-10.15h: Developmental patterning of synaptic connections in the retina
Rachel Wong
10.30h-11.45h: Synapse Formation and Maturation (I); Model Systems and Methods to Visualize Synapses
Ann Marie Craig
14-17h: Analysis and discussion of papers (Sala Leitura Serviço Bioquímica, 2º andar FMUC, Pólo III) – chaired by Rachel Wong
Armentano M, Chou SJ, Tomassy GS, Leingärtner A, O´Leary DD, Studer M.
COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.Nat Neurosci. 2007 Oct;10(10):1277-86.
Students presenting: Ana Sofia Azevedo & Susana Louros
Sharma J, Angelucci A, Sur M.
Induction of visual orientation modules in auditory cortex. Nature. 2000 Apr 20; 404(6780):841-7.
Students presenting: Ana Sofia Cabral & Sueli Marques

Wednesday, January 16
9h-10.15h: Synapse Formation and Maturation (II); Molecular Triggers
Ann Marie Craig
10.30h-11.45h: Studying Postsynaptic Receptor Function: Glutamate Receptors
Ana Luísa Carvalho
14-17h: Analysis and discussion of papers (Sala Leitura Serviço Bioquímica, 2º andar FMUC, Pólo III) – chaired by Ann Marie Craig
Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW, Sanes JR.
Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature. 2003 Jul 24;424(6947):430-4.
Students presenting: Filipe Leal & Sara Figueiredo
Kim S, Burette A, Chung HS, Kwon SK, Woo J, Lee HW, Kim K, Kim H, Weinberg RJ, Kim E.
NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Nat Neurosci. 2006 Oct;9(10):1294-301.
Students presenting: Gil Cunha, Nélio Mota Gonçalves & Joana Ferreira

Thursday, January 17
9h-10.15h: Trafficking of Glutamate Receptors
Ana Luísa Carvalho
10.30h-11.45h: Molecular Mechanisms of Synaptic Plasticity
Susana Correia
16h: CNC Seminar

Assembly and plasticity of hippocampal synapses”Ann MarieCraig
Friday, January 18
9h-10.15h: Modulators of Synaptic Plasticity
Susana Correia
10.30h-11.45h: Role of BDNF in the Regulation of Glutamatergic Synapses
Carlos B. Duarte
14-17h: Analysis and discussion of papers (Sala Leitura Serviço Bioquímica, 2º andar FMUC, Pólo III) – chaired by Susana Correia
Hu H, Real E, Takamiya K, Kang M-G, Ledoux J, Huganir RL, and Malinow R.
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking. Cell. 2007 Oct 5; 131:160–173.
Students presenting: Joana Marinho & Manuel Afonso Barroso
Wang X, Yang Y, and Zhou Q.
Independent Expression of Synaptic and Morphological Plasticity Associated with Long-Term Depression. J. Neurosci. 2007 Nov 7; 27(45):12419 –12429.
Students presenting: João Noutel Santos & Lígia Silva

Background reading:
O´Leary DD, Chou SJ, Sahara S.
Area patterning of the mammalian cortex. Neuron. 2007 Oct 25;56(2):252-69.
Horng SH, Sur M.
Visual activity and cortical rewiring: activity-dependent plasticity of cortical networks. Prog Brain Res. 2006;157:3-11.

Li Z, Sheng M.
Some assembly required: the development of neuronal synapses. Nat Rev Mol Cell Biol. 2003 Nov;4(11):833-41. Review
Waites CL, Craig AM, Garner CC.
Mechanisms of vertebrate synaptogenesis. Annu Rev Neurosci. 2005;28:251-74. Review.
Shepherd JD, Huganir RL.
The Cell Biology of Synaptic Plasticity: AMPA Receptor Trafficking. Annu. Rev. Cell Dev. Biol. 2007. 23:613–43.
Carvalho AL, Caldeira MV, Santos SD, Duarte CB.
Role of the brain-derived neurotrophic factor at glutamatergic synapses. British J. Pharmacol. 2007. Epub ahead of print.

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