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Development Biology
 
December 10 - 14
Sofia Araújo
Schedule
 

Monday (10/12)
 
10:00–11:00
Sofia Araújo – Introduction to the course
11:00–12:30
Rui Martinho – Early Invertebrate Development
12:30 – 14:30
Lunch
14:30 - 16:00
Leonor Saúde – How to achieve a perfect vertebrate body
16:00 – 17:30
Isabel Palmeirim – Techniques and strategies in the study of embryonic development
17:30 – 19:00
António Jacinto – Morphogenesis and Organogenesis
Tuesday (11/12)
 
10:00–11:00
Rui Martinho – Transcription and development
11:00–12:00
António Jacinto – Cell movements in development
12:00–13:00
Isabel Palmeirim – Molecular basis of time control during embryonic development
13:00 – 14:30
Lunch
14:30 - 15:30
Leonor Saúde – Mechanisms of symmetry breaking and establishment in vertebrates.
15.30 – 16.30
Journal club (I) preparation
16:30 – 19:00
I -Journal club presentation and discussion
Wednesday (12/12)
 
10:00–11:30
Sofia Araújo – Organogenesis in Drosophila – interplay between mechanisms and systems
11:30 – 13:00
Ginés Morata – The 20th century and the developmental biology revolution
13:00 – 14:30
Lunch
14.30 – 15.30
Ginés Morata – Compartments and growth control
15:30 – 17:00
Richard Hampson – Development for R&D
17.00 – 18.30
Dan Shaye – A Mighty Worm: C. elegans as a model to study the genetic control of development
Thursday (13/12)
 
10:00 – 11:30
Corinne Houart – Vertebrate Neurodevelopment - Zebrafish
11:30 – 13:00
Hector Herranz – micro-RNAs as mediators between signalling pathways and growth control during development
13:00 – 14:30
Lunch
14:30 – 16:00
Enrique Martin-Blanco – JNK signalling and the control of collective versus individual cell migration
16:00 – 17:00
Journal club (II) preparation
17:00 – 19:30
II - Journal club presentation and discussion
Friday (14/12)
 
10:00 – 11:30
Pedro Coutinho – Developmental Systems Biology
11:30 – 12:30
Dan Shaye – From Signals to Cell Behavior: how modulating intracellular trafficking regulates development in the Drosophila respiratory system.
12.30 – 14.00
Lunch
14.00 – 15.30
Diogo Castro – Transcriptional control, Stem Cells and Development
16.00
SeminarEnrique Martin-Blanco - Mechanisms directing epithelial cell replacement during morphogenesis
17.30-18.00
Course evaluation and goodbyes.

 
Speakers:
Sofia J. Araújo – course organizerIRB Barcelona, IBMB-CSIC
Parc Científic de Barcelona, Espanha
sarbmc@ibmb.csic.es
Rui Martinho
IGC, Oeiras, Portugal

Leonor Saúde
IGC, Oeiras, Portugal

António Jacinto
IMM, Lisboa, Portugal

Isabel Palmeirim
Univ. Minho, Portugal

Ginés Morata
Centro de Biología Molecular CSIC-UAM, Madrid, Espanha

Richard Hampson
Thelial Technologies, Portugal

Dan Shaye
IRB Barcelona, IBMB-CSIC
Parc Científic de Barcelona, Espanha

Corinne Houart
MRC Centre for Developmental Neurobiology
King’s College London, Reino Unido

Hector Herranz
IRB Barcelona
Parc Científic de Barcelona, Espanha

Enrique Martin-Blanco
IBMB-CSIC
Parc Científic de Barcelona, Espanha

Pedro Coutinho
MRC Human Genetics Unit
Edinburgh, Reino Unido

Diogo Castro
NIMR, Mill Hill, London, Reino Unido
 
Instructions for journal clubs:
We will have two journal clubs in this course. Their format will be slightly different and is explained below. You are free to choose the best way to present your paper(s). However, due to the format, I do encorage you to focus on the experiments and try to draw your own conclusions rather than describe what is written in the discussion. Try to be concise and focus on the critical experiments in each paper. For each exercise, the group presenting the paper will have a maximum time available for their presentation and then we will proceed with the discussion. All students should read all papers.

Tuesday 11th DECEMBER
Presentation time 12 min. Discussion time 20 min.
Each group will have to assume the paper they were assigned is their own work they are presenting for publication. During each presentation, two groups (the one presenting and another one) will be defending the work whereas the other two groups will take the role of referees and will decide if the paper is going to be accepted or rejected and why. I will be playing the editorial role, and the final decision will be taken at the end of the exercise. For each of these exercises you’ll need to be critical and constructive and you might (and should), as referees, propose more experiments that will improve the paper.
The order will be as follows:
Group I presents. Group II defends paper. Groups III and IV are referees.
Group II presents. Group III defends paper. Groups IV and I are referees.
Groups III presents. Groups IV defends paper. Groups I and II are referees.
Group IV presents. Group I defends paper. Groups II and III are referees.
Filipe Leal
Lígia Silva
Nélio Gonçalves
Group II – Rifs et al 2007
Ana Sofia Azevedo
Gil Cunha
Sara Figueiredo
Group III – Saude et al 2005
Ana Sofia Cabral
João Notel Santos
Sueli Marques
Group IV – Simoes et al 2006
Joana Marinho
Manuel Afonso Barroso
Susana Ribeiro Louros

Thursday 13th DECEMBER
Presentation time 30 min (15 min for each group) Discussion time 45 min.
For groups I and II there is additional information written by Dan Shaye.
For groups III and IV, an additional review article is provided.

Group I – Horwitz lab papers Lu and Horvitz, 1998. Thomas and Horvitz, 1999
Filipe Leal
Lígia Silva
Nélio Gonçalves
Ana Sofia Azevedo
Gil Cunha
Sara Figueiredo
Group III –Li and Baker, 2007
Ana Sofia Cabral
João Notel Santos
Sueli Marques
Joana Marinho
Manuel Afonso Barroso
Susana Ribeiro Louros

Reviews for groups III and IV - Morata and Martin, 2007; Gallant 2005.


Optional papers



Referências para procurar na biblioteca
Morata, G. and Lawrence, P.A. "Control of compartment development by the engrailed gene of Drosophila. Nature 265, 614-617 (1975).
 
Sánchez-Herrero, E., Vernos, I., Marco, R. and Morata, G. "Genetic organization of DrosophilaNature 313, 108-113 (1985) bithorax complex". 
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