Home
About BEB
Curriculum
Admission
CNC Research
BEB in the Media
 
 
Obesity & Type II Diabetes
 
March 9 - 13
Optional Course

John Jones and Eugénia Carvalho
Fuelling of Obesity and Type 2 Diabetes
9-12th March
Co-ordinators: 
Eugenia Carvalho and John G. Jones
Invited Faculty:
 
Kim,Young-Bum
Assistant Professor of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston USA.
Robert O´Doherty
Associate Professor, Division of Endocrinology and Metabolism University of Pittsburgh Medical Center and University College Cork, College of Medicine and Health, Cork, Ireland.
Donald Scott
Visiting Associate Professor of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, USA.
Janice Zabolotny
Assistant Professor of Medicine, Division of Endocrinology, Diabetes and
Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston USA
 
 Monday, March 9 2009:
 
9:30  Lecture:                               
Nutrient regulation of cellular phenotype: history and methodology
 Prof. Donald Scott
 
11:00   Lecture:                               
Nutrient regulation of cellular phenotype: transcription factors and relation to obesity and diabetes
Prof. Donald Scott
 
12:00-14:00                                        
Lunch
 
14:00-15:00                                        
Paper 1 discussion:             
c-Myc and ChREBP regulate glucose-mediated expression of  the L-type pyruvate kinase gene in INS-1-derived 832/13 cells
Ana Costa & Joana Real
 
15:30-16:30                                        
Paper 2 discussion:             
cAMP opposes the glucose-mediated induction of the L-PK  gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP.”                                Marta Pasadouro & Alice Melao
 
Tuesday, March 10 2009:
 
9:30   Lecture:               
“Inflammation and diabesity: history, methods, and models”
Prof. Robert O´Doherty
 
11:00  Lecture:               
“Inflammation and diabesity: recent advances”
Prof. Robert O´Doherty
 
 12:00-14:00                                        
Lunch
 
 14:00-15:00                                        
Paper 3 discussion:             
Depletion of Liver Kupffer Cells Prevents the Development of  Diet-Induced Hepatic Steatosis and Insulin Resistance
Susana Cardoso & Renato Santos
 
15:30-16:30                                        
Paper 4 discussion:             
Leptin Augments the Acute Suppressive Effects of Insulin on Hepatic VLDL Production in Rats
Ana Tellechea & Sandra Nunes
 
Wednesday, March 11 2009:
 
9:30        Lecture:                               
“Molecular mechanism of insulin resistance in obesity and diabetes”
Prof. Young-Bum Kim
 
11:00     Lecture:                               
“Leptin and its physiological role”  
Prof. Young-Bum Kim                    
 
12:00-14:00                                        
Lunch
 
14:00-15:00                                        
Paper 5 discussion:             
Role of Rho-kinase in regulation of insulin action and glucose homeostasis
Joana Pedro & Lucilia Silva
 
15:30-16:30                                        
Paper 6 discussion:             
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Pedro Reu
 
Thursday, March 12 2009:
 
9:30  Lecture:                               
"Roles of Protein Tyrosine Phosphatases in Negatively Regulating Insulin and Leptin
Action in Vivo"
Prof. Janice Zabolotny
 
11:00     Lecture:                            
"Inflammation as a Regulator of Protein Tyrosine Phosphatase 1B in Metabolic Disease"
Prof. Janice Zabolotny
 
 12:00-13:30                                        
Lunch
 
 13:30-14:30                                        
Paper 7 discussion:             
PTP1B Regulates Leptin Signal Transduction In Vivo
Ana Ruffino
 
14:45-15:45                         
Paper 8 discussion:             
Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin
Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not
Additively Impair Insulin Action
JoaoDuarte
 
16:00    Invited CNC Lecture
“Identification of Rho-kinase as a new regulator of insulin action”
Professor Young-Bum Kim
17:30                                    
 And finally................We invite you to the Mathematics bar to sample some home-made beer. No course should be without it!
 
Course sponsors:
                FCT
                Frilabo
                TracerTec
                Reagent 5
                Hucoa Erloss


Papers

Role of Rho-kinase in regulation of insulin action and glucose homeostasis

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP.

c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

AMP-kinase regulates food intake by responding to hormonal and nutrient
signals in the hypothalamus

Leptin Augments the Acute Suppressive Effects of Insulin on Hepatic VLDL
Production in Rats

Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action*

PTP1B Regulates Leptin Signal Transduction In Vivo

back
 
© 2017 BEB - Doctoral Programme in Experimental Biology and Biomedicine powered by ponto.C