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Neurodegenerative Disorders
 
February 16 - 20
Ana Cristina Rego, Paula Agostinho, Cláudia Pereira, Luís Pereira de Almeida

Neurodegenerative disorders

(February 16-20, 2009)

Center for Neuroscience and Cell Biology, PDBED room (1st floor), Faculty of Medicine - Polo I

 
Coordinators:
Ana Cristina Rego (acrego@cnc.cj.uc.pt)
Cláudia Pereira (cpereira@cnc.cj.uc.pt)
Luís Pereira de Almeida (luispa@ci.uc.pt)
Paula Agostinho (pagost@cnc.cj.uc.pt)
-Center for Neuroscience and Cell Biology, University of Coimbra

Invited Lecturers:
Nicolas Sergeant
INSERM U837, Centre Jean Pierre Aubert, IMPRT, Univ. Lille II
Maladies Neurodégénératives & Mort Neuronale1, Place de Verdun
59045 Lille cedex France (nicolas.sergeant@inserm.fr)

Asa Petersen
Head, Translational Neuroendocrine Research Unit,
Department of Experimental Medical Science,
Lund University, Sweden (Asa.Petersen@med.lu.se)

Ernest Arenas
Stem Cell Neurobiology Unit,
Department of Medical Biochemistry and Biophysics

Karolinska Institutet, Stockholm, Sweden (ernest.arenas@ki.se)

Cristina Januário -Serviço de Neurologia, Hospitais da Universidade de Coimbra
(cristinajanuario@gmail.com)

Isabel Santana -Serviço de Neurologia, Hospitais da Universidade de Coimbra
(isabelsantana@huc.min-saude.pt)

Tiago Outeiro -Harvard Medical School, Boston, USA and Instituto de Medicina Molecular, Lisboa, Portugal
(touteiro@gmail.com)
Course Schedule:

Monday (Feb 16)
10:00-10:45- Overview of general aspects of neurodegenerative disorders
A. Cristina Rego
10:45-11:00- Break
11:00-12:00- Overview of Alzheimer s disease and Tauopathies: epidemiology, genetics,
neuropathology and diagnosis
Nicolas Sergeant
12:00-12:15- Discussion
12:15-14:00- Lunch
14:00-14:30- Clinical features of Parkinson s disease
Cristina Januário
14:30-15:00- Clinical features of Huntington s disease
Cristina Januário
15:00-15:15- Discussion
15:15-16:00- Clinical aspects of Alzheimer s disease
Isabel Santana
16:00-16:15- Discussion
16:15-16:30- Presentation of student s assignments

Tuesday (Feb 17)
9:30-10:30- Huntington s disease - from clinical aspects to pathogenic properties of
expanded polyglutamines
Asa Petersen
10:30-10:45- Discussion
10:45-11:00- Break
11:00-12:00- Tau gene, Tau splicing, Tau proteins, Tau pathology and aggregation:
from molecular aspects to experimental models
Nicolas Sergeant
12:00-12:15- Discussion
12:15-14:00- Lunch
14:00-15:00- APP processing, amyloid pathology and links to neurodegeneration
Nicolas Sergeant
15:00-15:15- Discussion
15:15-16:15- Monitoring protein conformations in vivo: molecular studies in Parkinson s disease
Tiago Outeiro
16:15-16:30- Discussion

Wednesday (Feb 18)
9:30-10:30- Animal models of Huntington s disease
Asa Petersen
10:30-10:45- Discussion
10:45-11:00- Break
11:00-12:00- Molecular markers in Alzheimer s disease: useful tools for diagnosis
and therapeutic targets
Nicolas Sergeant
12:00-12:15- Discussion
12:15-14:00- Lunch
14:00-14:30- Mitochondrial dysfunction in Alzheimer’s disease:
lessons from cellular and transgenic animal models
Cláudia Pereira
14:30-14:45- Discussion
14:45-15:15- Glial activation triggered by Abeta: role in AD associated
neuronal dysfunction
Paula Agostinho
15:15-15:30- Discussion
15:30-16:00- Cell death features and mitochondrial dysfunction in Huntington s disease
– role of BDNF
A. Cristina Rego
16:00-16:15- Discussion
16:15-16:30- Break
16:30-17:00- Gene transfer with viral vectors for modelling and therapy of
Machado-Joseph disease
Luís Pereira de Almeida

Thursday (Feb 19)
9:30-10:30- Stem cells as disease models and tools for neuroprotective therapy
Ernest Arenas
10:30-10:45- Discussion
10:45-11:00- Break
11:10-12:00- Dopaminergic differentiation of neural progenitors: learning from
development
Ernest Arenas
12:00-12:15- Discussion
12:15-14:00- Lunch
14:00-15:00- Neuroendocrine changes in Huntington s disease
Asa Petersen
15:00-15:15- Discussion
15:15-16:15- Stem cell-derived dopaminergic neurons: Tools for drug discovery
Ernest Arenas
16:15-16:30- Discussion
16:30-16:45- Break
16:45-17:45- Paper presentation by students + Discussion

Paper 1
Students (Group 1): Ana Lúcia Ramos, Joana Barbosa, João Costa
Cowan CM et al. (2008) J Neurosci. 28:12725-35

Paper 2
Students (Group 2): Ana Sofia Rodrigues, Marco F. Craveiro, Ana Catarina Fonseca
Lorincz MT, Zawistowski VA. (2009) Mol Cell Neurosci. 40:1-13.

Friday (Feb 20)
10:00-12:00- Paper presentation by students + Discussion

Paper 3
Students (Group 3): Beatriz Sousa, Diana Carvalho, Elisabete Augusto
Schilling S et al. (2008) Nat Med. 14:1106-11

Paper 4
Students (Group 4): Carolina Coelho, Pedro Carvalho, Sandra Mota
Parish CL et al. (2008) J Clin Invest. 118:149-60

Paper 5
Students (Group 5): Carlos Melo, Samira Ferreira
Kramer ML, Schulz-Schaeffer WJ. (2007) J Neurosci. 27:1405-10

Paper 6
Students (Group 6): Renata Gomes, Sílvia Silva
Dreses-Werringloer U et al. (2008) Cell. 133:1149-61
 
16:00-17:00- Seminar: Stem cell replacement therapy for Parkinson s disease and regeneration
Ernest Arenas
Stem Cell Neurobiology Unit
Department of Medical Biochemistry and Biophysics
Karolinska Institutet, Stockholm, Sweden (ernest.arenas@ki.se)

Additional papers

- Cardoso SM, Moreira PI, Agostinho P, Pereira C, Oliveira CR. (2005) Neurodegenerative pathways in  Parkinson s disease: therapeutic strategies. Curr Drug Targets CNS Neurol Disord. 4:405-19.

- Deierborg T, Soulet D, Roybon L, Hall V, Brundin P. (2008) Emerging restorative treatments for  Parkinson s disease. Prog Neurobiol. 85:407-32.

- Delacourte A. (2008) Tau pathology and neurodegeneration: an obvious but misunderstood link. J Alzheimers Dis. 14:437-40.

- Gil JM, Rego AC. (2008) Mechanisms of neurodegeneration in Huntington s disease.
Eur J Neurosci. 27:2803-20.

- Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. (2008) Huntington s disease: from pathology and genetics to potential therapies. Biochem J. 412:191-209.

- Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR. (2005) Alzheimer s disease-associated neurotoxic mechanisms and neuroprotective strategies. Curr Drug Targets CNS Neurol Disord. 4:383-403.

- Perfeito R., Rego A. C. (2008) Post-translational modifications of alpha-synuclein and mitochondrial dysfunction in Parkinson s disease. In: ‘Protein Misfolding in Biology and Disease (Outeiro T., Ed.) Transworld Research Network,Cap.7, pp. 203-230 (ISBN: 978-81-7895-345-8).

- Petersén A, Björkqvist M. (2006) Hypothalamic-endocrine aspects in Huntington s disease. Eur J Neurosci. 24:961-7.

- Rego AC, de Almeida LP. (2005) Molecular targets and therapeutic strategies in Huntington s disease. Curr Drug Targets CNS Neurol Disord. 4:361-81.
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