About BEB
CNC Research
BEB in the Media
Cell Death
January 26 - 30
Armanda Santos

Course Sponsor: Biogen Idec
Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology (CNC) - University of Coimbra
Coimbra, 26-30 January 2009

Coordinator: Armanda Emanuela Santos (aesantos@ci.uc.pt)


Jonathan Ham
Molecular Haematology and Cancer Biology Unit,
Camelia Botnar Laboratories
Institute of Child Health
University College London
London WC1N 1EH, UK

Michael J. Courtney
Dept. of Neurobiology
A. I. Virtanen Institute
University of Kuopio
Kuopio FIN 70211, Finland

Luis Miguel Martins
Cell Death Regulation Laboratory
MRC Toxicology Unit
Leicester LE1 9HN, UK

Armanda E. Santos
Center for Neuroscience and Cell Biology &
Faculty of Pharmacy
University of Coimbra
3004-517 Coimbra, Portugal


Monday, January 26

I: Introduction to apoptosis
Jonathan Ham

II: Introduction to mitochondria
Luís Miguel Martins

Tuesday, January 27

I: Regulation of the cell death programme by signalling pathways
Jonathan Ham

II: Stress-activated protein kinases in cell death
Michael Courtney

III: Analysis and discussion of papers
Jonathan Ham

Note: Student presentations should not take more than 30 minutes per paper

Wednesday, January 28

I: Transcriptional control of apoptosis
Jonathan Ham

II: Mitochondrial stress pathways and cell death
Luís Miguel Martins

III: Analysis and discussion of papers
Luís Miguel Martins

Thursday, January 29

I: Mechanisms of glutamate receptor mediated excitotoxic neuronal death I: Ca2+-permeable AMPA receptor-mediated excitotoxicity
Armanda Santos

II: Mechanisms of glutamate receptor mediated excitotoxic neuronal death II: NMDA receptors and associated proteins in excitotoxicity
Michael Courtney

III: Analysis and discussion of papers
Michael Courtney

Friday, January 30

I: New perspectives in targeting excitotoxicity / Seminar
Michael Courtney

16h: CNC seminar
Danial NN & Korsmeyer SJ. (2004)
Cell death: critical control points.
Cell 116: 205-219. Review.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, and Cheng EH. (2006)
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
Nat Cell Biol. 8: 1348-1358.

Willis SN & Adams JM. (2005)
Life in the balance: how BH3-only proteins induce apoptosis.
Curr Opin Cell Biol. 17: 617-625. Review.

Hengartner MO. (2000)
The biochemistry of apoptosis.
Nature 407: 770-776. Review.

Thellmann M, Hatzold J and Conradt B. (2003)
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins.
Development 130: 4057-4071.
Whitfield, J., Neame, S.J., Paquet, L., Bernard, O. and Ham, J. (2001)
Dominant negative c-Jun promotes neuronal survival by reducing Bim expression and inhibiting mitochondrial cytochrome c release.  Neuron 29, 629-643.
Gilley, J., Coffer, P. and Ham, J. (2003)
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
Journal of Cell Biology 162, 613-622.

Ham, J., Towers, E., Gilley, J., Terzano, S. and Randall, R.A. (2005)
BH3-only proteins:  key regulators of neuronal apoptosis. 
Cell Death and Differentiation 12, 1015-1020.
Liu SJ & Zukin RS. (2007)
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death.
TINS 30: 126-134
Kwak S & Weiss JH. (2006)
Calcium-permeable AMPA channels in neurodegenerative disease and ischemia.
Curr Op Neurobiol 16: 281-287
Santos AE, Duarte CB, Iizuka M, Barsoumian EL, Ham J, Lopes MC, Carvalho AP, and Carvalho AL. (2006)
Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor.
Cell Death Differ 13:652-60
Borsello T, Clarke PG, Hirt L, Vercelli A, Repici M, Schorderet DF, Bogousslavsky J, Bonny C (2003)
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Nat Med. 9:1180-6.
Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ (2004)
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death.
J Biol Chem. 279:35903-13.
Wang LH, Besirli CG, Johnson EM Jr (2004)
Mixed-lineage kinases: a target for the prevention of neurodegeneration.
Annu Rev Pharmacol Toxicol. 44:451-74.
© 2021 BEB - Doctoral Programme in Experimental Biology and Biomedicine powered by Digitalwind