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Cell Death
 
January 26 - 30
Armanda Santos

Course Sponsor: Biogen Idec
Doctoral Programme in Experimental Biology and Biomedicine
Center for Neuroscience and Cell Biology (CNC) - University of Coimbra
Coimbra, 26-30 January 2009

Coordinator: Armanda Emanuela Santos (aesantos@ci.uc.pt)

LECTURERS:

Jonathan Ham
Molecular Haematology and Cancer Biology Unit,
Camelia Botnar Laboratories
Institute of Child Health
University College London
London WC1N 1EH, UK
(J.Ham@ich.ucl.ac.uk)

Michael J. Courtney
Dept. of Neurobiology
A. I. Virtanen Institute
University of Kuopio
Kuopio FIN 70211, Finland
(courtney@messi.uku.fi)

Luis Miguel Martins
Cell Death Regulation Laboratory
MRC Toxicology Unit
Leicester LE1 9HN, UK
(lmm24@leicester.ac.uk)

Armanda E. Santos
Center for Neuroscience and Cell Biology &
Faculty of Pharmacy
University of Coimbra
3004-517 Coimbra, Portugal
 

COURSE SCHEDULE:

Monday, January 26

I: Introduction to apoptosis
Jonathan Ham

II: Introduction to mitochondria
Luís Miguel Martins

Tuesday, January 27

I: Regulation of the cell death programme by signalling pathways
Jonathan Ham

II: Stress-activated protein kinases in cell death
Michael Courtney

III: Analysis and discussion of papers
Jonathan Ham

Note: Student presentations should not take more than 30 minutes per paper

Wednesday, January 28

I: Transcriptional control of apoptosis
Jonathan Ham

II: Mitochondrial stress pathways and cell death
Luís Miguel Martins

III: Analysis and discussion of papers
Luís Miguel Martins

Thursday, January 29

I: Mechanisms of glutamate receptor mediated excitotoxic neuronal death I: Ca2+-permeable AMPA receptor-mediated excitotoxicity
Armanda Santos

II: Mechanisms of glutamate receptor mediated excitotoxic neuronal death II: NMDA receptors and associated proteins in excitotoxicity
Michael Courtney

III: Analysis and discussion of papers
Michael Courtney

Friday, January 30

I: New perspectives in targeting excitotoxicity / Seminar
Michael Courtney

16h: CNC seminar
 
BACKGROUND READING
Danial NN & Korsmeyer SJ. (2004)
Cell death: critical control points.
Cell 116: 205-219. Review.

Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, and Cheng EH. (2006)
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
Nat Cell Biol. 8: 1348-1358.

Willis SN & Adams JM. (2005)
Life in the balance: how BH3-only proteins induce apoptosis.
Curr Opin Cell Biol. 17: 617-625. Review.

Hengartner MO. (2000)
The biochemistry of apoptosis.
Nature 407: 770-776. Review.

Thellmann M, Hatzold J and Conradt B. (2003)
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins.
Development 130: 4057-4071.
Whitfield, J., Neame, S.J., Paquet, L., Bernard, O. and Ham, J. (2001)
Dominant negative c-Jun promotes neuronal survival by reducing Bim expression and inhibiting mitochondrial cytochrome c release.  Neuron 29, 629-643.
Gilley, J., Coffer, P. and Ham, J. (2003)
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
Journal of Cell Biology 162, 613-622.

Ham, J., Towers, E., Gilley, J., Terzano, S. and Randall, R.A. (2005)
BH3-only proteins:  key regulators of neuronal apoptosis. 
Cell Death and Differentiation 12, 1015-1020.
Liu SJ & Zukin RS. (2007)
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death.
TINS 30: 126-134
Kwak S & Weiss JH. (2006)
Calcium-permeable AMPA channels in neurodegenerative disease and ischemia.
Curr Op Neurobiol 16: 281-287
Santos AE, Duarte CB, Iizuka M, Barsoumian EL, Ham J, Lopes MC, Carvalho AP, and Carvalho AL. (2006)
Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor.
Cell Death Differ 13:652-60
Borsello T, Clarke PG, Hirt L, Vercelli A, Repici M, Schorderet DF, Bogousslavsky J, Bonny C (2003)
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Nat Med. 9:1180-6.
Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ (2004)
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death.
J Biol Chem. 279:35903-13.
Wang LH, Besirli CG, Johnson EM Jr (2004)
Mixed-lineage kinases: a target for the prevention of neurodegeneration.
Annu Rev Pharmacol Toxicol. 44:451-74.
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