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Molecular Cell Biology
 
November 17 - 21
Edgar Gomes, João Ramalho-Santos
MOLECULAR CELL BIOLOGY
17-21 November
Coordinators:
Edgar R. Gomes (UPMC, Paris, France),
João Ramalho-Santos (Univ. Coimbra, Portugal)

Lecturers:
Phong Tran
U. of Pennsylvania, Philadelphia USA &
Institut Curie, Paris
France
Clare Waterman
National Institutes of Health
Bethesda Maryland,
USA
Edgar R. Gomes
U. Pierre et Marie Curie, Paris
France
Helder Maiato
IBMC, U. do Porto, Porto
Portugal
Monday, November 17 
10:00 - Introduction
10:30 – A tale of three filaments (part I) (Edgar)
11:30 – Lunch break
13:15 - A tale of three filaments (part II) (Edgar)
14:45 – Break
15:15 – Imaging in Cell Biology (part I) (Phong)
16:30 – End
Tuesday, November 18 
9:30 – Imaging in Cell Biology (part II) (Phong)
10:30 – Break
11:00 – Mitosis I (Helder)
12:00 – Lunch Break
14:00 – Mitosis II (Helder)
15:30 – Paper 1: (Selected by Helder Maiato)
16:30 - End
Wednesday, November 19 
9:00 – Paper 2: (selected by Edgar Gomes)
10:00 – Break
10:30 – Controlling the cytoskeleton (Edgar)
11:30 – Lunch Break
14:00 – Paper 3: (selected by Edgar Gomes)
15:15 - Paper 4: (selected by Phong Tran)
16:30 - End
Thursday, November 20 
Time – Lecture
9:00 – Cell Migration I (Clare)
10:15 – Break
10:45 – Cell Migration II (Clare)
11:45 Lunch Break
14:00 - Paper 5: (selected by Phong Tran)
15:15 – Paper 6: (selected by Clare Waterman)
20:00 – “official” course dinner.
Friday, November 21 
11:00 – Paper 7: (selected by Clare Waterman)
12:30 – Lunch Break
16:00 – Seminar – “Integrating actin dynamics with adhesion in cell migration ” Clare Waterman

Papers for the journal club:
Paper 1:
Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032-42(2008).
Paper 2:
Vale, R.D., Reese, T.S. & Sheetz, M.P. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 42, 39-50(1985).
Paper 3:
Hsin-Yi Henry Ho et al. (2004) Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118, 203-216.
Paper 4:
Janson, M.E. et al. Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Cell 128, 357-68(2007).
Paper 5:
Brouhard, G.J. et al. XMAP215 is a processive microtubule polymerase. Cell 132, 79-88(2008).
Paper 6: (two papers)
Ponti, A. et al. Two Distinct Actin Networks Drive the Protrusion of Migrating Cells. Science 305, 1782-1786(2004).
Gupton, S.L. et al. Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol 168, 619-31(2005).
Paper 7:
Hu, K. et al. Differential transmission of actin motion within focal adhesions. Science 315, 111-5(2007).
Recommended reading:
“The Cytoskeleton”, Chapter 16, Molecular Biology of the Cell, Fourth Edition, by Bruce Alberts et al.
T. Pollard, G. Borisy, Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Cell 112 (4), 453 (2003)
Siegrist SE, Doe CQ. (2007). Microtubule-induced cortical cell polarity. Genes Dev 21, 483-96.
David R. Burgess and Fred Chang
Site selection for the cleavage furrow at cytokinesis
Trends in Cell Biology 15:156-162, 2005
Myrto Raftopoulou and Alan Hall (2004) Cell migration: Rho GTPases lead
the way. Dev Biol 265, 23-32.
Gregg G. Gundersen (2002) Evolutionary conservation of
microtubule-capture mechanisms. Nature Rev Mol Cell Biol 3, 6-14.
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