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PDBEB Courses 2020/2021 - Advanced Therapies
April 19 - 23
Coordinators: Luís Almeida - luispa@cnc.uc.pt, Lino Ferreira - lino.ferreira@uc.pt & Rita Perfeito - rita.perfeito@uc.pt
PDBEB Course Advanced Therapies
April 19 - 23, 2021

Location: Online

Luís Pereira de Almeida, Lino Ferreira & Rita Perfeito


Monday (April 19th)

9:00-10:00 – “Mechanomodulation of stem and progenitor cells”
Mario Grãos (CNC)

10:00-11:00- “Reprogramming cells for medicine”
Ricardo Neves (CNC)

11:00-11:15- Coffee break

11:15-12:15- “Biomolecular engineering for regenerative medicine”
Hugo Fernandes (Univ. Coimbra)

12:15- 14:00- Lunch

14:00- 15:00 “Biomaterials to regulate cell activity”
Lino Ferreira (CNC and Univ. Coimbra)

15:00- 16:00 “Engineered nanomaterials for fighting bacteria and healing wounds”
Akhilesh Rai (CNC and Univ. Coimbra)

16:00- 16:15- Coffee break

16:15- 17:15 “Biomaterial-based cell therapies for the revascularization of ischemic tissues”
Cristina Barrias (Univ. Porto)

Tuesday (April 20th)

9:00- 10:00- “Pluripotent stem cells: biology and applications”
Lino Ferreira (CNC and Univ. Coimbra)

10:00- 11:00- “Engineering specialised heart muscle cells for disease modelling and pharma-use using human pluripotent stem cells”
Andreia Bernardo (Crick Institute)

11:00- 11:15- Coffee break

11:15- 12:15- “Use of pluripotent stem cells for drug discovery applications”
Xavier Nissan (I-STEM, Paris)

12:15- 14:00- Lunch

14:00- 15:00- “Stem cell based therapies in retinal disease: a preclinical roadmap”
Alexandra Capela 

15:00- 16:00- “MicroRNA therapy: from basic science to clinical reality”
Paula Costa Martins (Univ. Maastricht)

Wednesday (April 21st)

9:00- 10:00- “Molecular therapies for brain disorders”
Luís Pereira de Almeida (CNC)

10:00- 10:45- "Thinking small: miRNA-mediated gene silencing and miRNA-based therapeutic approaches"
Sónia Duarte (CNC)

10:45- 11:15- "miRNA dysregulation in Machado-Joseph Disease" 
Diana Santos (CNC)

11:15- 11:30- Coffee Break

11:30- 12:15- “Intravenous delivery of the brain-targeting AAV-PHPeB encoding CYP46A1 to overcome brain cholesterol deregulation in neurodegenerative disorders – focusing on Machado Joseph disease”
Rita Perfeito (CNC)

12:15- 14:00- Lunch

14:00- 14:45- “Stem cell transplantation for brain regeneration and neuroprotection”
Liliana Mendonça (CNC)

14:45- 15.30- “iPSC-derived neuroepithelial stem cells depleted for mutant ataxin-3 for Machado-Joseph disease treatment”
Sandra Braz (CNC)

15:30- 15:45- Coffee Break

15:45- 16.30- “Therapies based on gene editing: Potentialities and limitations”
Sara Lopes (CNC)

16:30- 17:15- "Genome editing 2.0: CRISPR-base editors"
Pedro Perdigão (CNC)

Thursday (April 22nd)

09:00- 09.45- “Mesenchymal Stem Cells for Brain Disorders - the Particular Case of Machado-Joseph Disease”
Catarina Miranda (CNC)

09:45- 10:30- "Proteolysis as a target in neurodegenerative disorders and the particular case of Machado-Joseph Disease"
Dina Pereira (CNC)

10:30- 10:45- Coffee Break 

10:45- 11:30- “Addressing the cancer patients’ needs with nanomedicine-based strategies
João Nuno Moreira (CNC)

11:30- 12:15- “Differential effect of F3 peptide-targeted liposomes containing doxorubicin and C6-ceramide and non-targeted drug combinations against nucleolin-overexpressing cancer cell lines"
Ana Filipa Cruz (CNC)

12:15- 14:00- Lunch

14:00- 14:45- “Viral vectors for Gene therapy: from the lab to the clinic"
Rui Nobre (CNC, Vira-Vector UC) 

14:45- 15:30- “Extracellular vesicles as a therapeutic approach for CNS disorders”
Patrícia Albuquerque (CNC)

15:30- 15.45- Coffee Break

15:45- 16:30- “Shedding Light on Chitosan-based Nanoparticles as Intranasal Vaccine Adjuvant”
Olga Borges (CNC)

16:30- 17:15- "Biomarkers in drug development"
Magda Santana (CNC)

Friday (April 23rd)

09.00- 12:30- Assignments- Presentation of papers

12:30- 14:00- Lunch

15:30- Seminar : “Overcoming barriers for brain gene therapy
Prof. Beverly L. Davidson, PhD (Perelman School of Medicine,
University of Pennsylvania, USA)

Zoom Meeting 

Password: 898046

Beverly L. Davidson, is the Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Chief Scientific Strategy Officer, and holds the Arthur V. Meigs Chair in Pediatrics at Children´s Hospital of Philadelphia. She is Professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.  She received her B.S. in Biology from Nebraska Wesleyan University, and Ph.D. in Biological Chemistry from University of Michigan. 


Professor Davidson´s research is focused on inherited genetic diseases that cause central nervous system dysfunction, with an emphasis on recessive, childhood onset neurodegenerative disease; dominant genetic diseases; and understanding how noncoding RNAs participate in neural development and neurodegenerative diseases process.

Recent honors include election into the American Academy of Arts and Sciences and the National Academy of Medicine.  She is president-elect of the American Society of Gene and Cell Therapy, the largest international association of gene and cell therapy research.  

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