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PDBEB Courses 2020/2021 - High-Throughput Screening for Target and Drug Discovery
 
February 1 - 5
Coordinators: Miguel Mano - mano@ci.uc.pt

PDBEB Courses 2020/2021 - High-Throughput Screening for Target and Drug Discovery


Date: February 1-5, 2021

Location: UC-Biotech, Cantanhede



Maximum number of students: 30


Coordinators:

Miguel Mano mano@ci.uc.pt 


Lecturers:

Luca Braga (International Centre for Genetic Engineering and Biotechnology, Italy)

Mauro Giacca (King’s College London, UK)

Neville Sanjana (New York University, USA)

Peter Horvath (Szeged Biological Research Centre, Hungary and Institute for Molecular Medicine Finland, Finland)

Roderick Beijersbergen (The Netherlands Cancer Institute, The Netherlands)

Valentina Adami (University of Trento, Italy)

Ana Eulalio (CNC & DCV, University of Coimbra)

Laura Alcantara (CNC, University of Coimbra)

Miguel Mano (CNC & DCV, University of Coimbra)

Ricardo Silva (CNC, University of Coimbra)



PROGRAMME

Monday (February 1st)

9.30-10.00 – Welcome and introduction to the course 

Miguel Mano


10.00-12.30 – Screening 101: from basic concepts to practical aspects of implementing large-scale functional genomics screenings

Miguel Mano


14.00-15.00 – Principles of automated image analysis & lab tour

Miguel Mano


15.00-17.30 – Hands-on session I: image analysis – Columbus

Miguel Mano 



Tuesday (February 2nd)

9.30-11.30 – High throughput screening in drug discovery

Valentina Adami (University of Trento, Italy)


11.45-12.45 – Small molecule screening: examples from an academic Core Facility

Valentina Adami (University of Trento, Italy)


14.00-17.30 – Hands-on session II: image analysis – Cellprofiler

Ricardo Silva



Wednesday (February 3rd)

9.30-10.30 – CRISPR/Cas9: precise genome editing and beyond

Miguel Mano


10.45-12.15 – Pooled CRISPR screening: Finding needles in the haystack

Roderick Beijersbergen (The Netherlands Cancer Institute, The Netherlands)


15.00-16.30 –  Functional selection of tissue protective factors using AAV vector screenings in mice

Mauro Giacca (King’s College London, UK)



Thursday (February 4th)

9.30-10.30 – Drug repurposing for COVID-19 using image-based high-throughput screening

Luca Braga (International Centre for Genetic Engineering and Biotechnology, Italy)


10.45-11.45 – Exploring high-content screening to dissect the role of microRNAs in bacterial infection

Ana Eulalio


12.00-13.00 – Translational research and drug discovery for neglected tropical diseases: strategies based on drug combinations and repurposing

Laura Alcantara 


14.00-15.30 – New frontiers in target and drug discovery using massively-parallel CRISPR screens

Neville Sanjana (New York University, USA)


16.00-17.30 – Life beyond the pixels: deep learning methods for single cell analysis

Peter Horvath (Szeged Biological Research Centre, Hungary & Institute for Molecular Medicine Finland, Finland)



Friday (February 5th)

14.00-17.00 – Student presentations and wrap-up


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