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PDBEB Courses 2019/2020 - The Avenging Metabolism in Human Disease: Endgame!
March 9 - 13
Coordinators: Paulo Oliveira - pauloliv@ci.uc.pt & João Ramalho-Santos - jramalho@uc.pt

Doctoral Program in Experimental Biology and Biomedicine (PDBEB)
2019/2020 Edition

The Avenging Metabolism in Human Disease: Endgame! @ CNC

March 9 – March 13, 2020

Registration is mandatory here.

Deadline for registration: March 1, 2020

Paulo Oliveira - pauloliv@ci.uc.pt & João Ramalho-Santos - jramalho@uc.pt



Ana Urbano; DCV, University of Coimbra
Anabela Marisa Azul; CNC/CIBB, University of Coimbra
Enrico Tatti ou Barry Bochner; Biolog, USA
Fátima Baltazar; University of Minho
Fernanda Borges; University of Porto
Filomena Silva; CNC/CIBB, University of Coimbra
Francisco Pereira; DEI, University of Coimbra
João Ramalho-Santos; CNC/CIBB, University of Coimbra
João Teodoro; CNC/CIBB, University of Coimbra
John Jones; SEAentia and CNC/CIBB, University of Coimbra
José Teixeira; CNC/CIBB, University of Coimbra
Manuela Ferreira; CNC/CIBB, University of Coimbra
Maria Kristiansen, University of Copenhagen, Denmark
Nuno Raimundo; CNC/CIBB, University of Coimbra
Paulo Matafome; iCBR/CIBB, University of Coimbra
Paulo Oliveira; CNC/CIBB, University of Coimbra
Pedro Russo; Univ Leiden
Ruth Koops van t Jagt; Aletta Jacobs School of Public Health, Univ Groningen, The Netherlands
Sara Araújo; CES/UC; FEUC
Teresa Oliveira; CNC
Vilma Sardão; CNC/CIBB, University of Coimbra
Zofia Chrzanowska-Lightowlers; Newcastle University


Date: March 9 – March 13, 2020

Location: CNC


March 9: Metabolism for Dummies

Morning: The Fundamentals of Cell Metabolism

9h30 - 10h00: Course introduction and group assignments

10h00 - 10h45: John Jones (CNC/CIBB, Portugal), “What is metabolism?”

10h45 - 11h00: Break

11h00 - 11h45: Paulo Oliveira (CNC/CIBB, Portugal), “Power-Up: The follies of mitochondrial metabolism in health and disease”

Afternoon: Techniques and Models to Study Cell Metabolism

14h00 - 14h45: Vilma Sardão (CNC/CIBB, Portugal), ”Methodologies for assessing mitochondrial respiration”

14h45 - 15h30: Paulo Matafome (iCBR/CIBB, Portugal) “Models for the study of metabolism”

15h30 - 15h45 - Break

15h45 - 16h30: Enrico Tatti ou Barry Bochner (Biolog, USA) “Funcional metabolomics” (via GotoMeeting)

16h30 - 17h15: Francisco Pereira (DEI/UC, Portugal) and Teresa Oliveira (CNC, Portugal) “Bioinformatics and machine learning in cell biology and metabolism”

17h15: Students group work

March 10: The Revenge of Metabolism I: Metabolism and Disease

Morning: Genetic and Lifestyle diseases

9h30 - 10h15: Nuno Raimundo (CNC/CIBB, Portugal) “Iron Man, T(h)or and Elektra - tales of mitochondria and lysosomes”

10h15 - 11h00: Zofia Chrzanowska-Lightowlers (Newcastle University) “Mitochondria : when does friend turn foe?”

11h00 - 11h15: Break

11h15 - 12h00: Pedro Russo (Univ Leiden), “The Public and Researchers: It is Complicated

Afternoon:  Immunometabolism and Cancer

14h00 - 14h25: Ana Urbano (DCV/UC, Portugal), “Oncometabolism: Warburg and beyond”

14h25 - 15h10: Fátima Baltazar (University of Minho, Portugal), “Lactate beyond a waste metabolite: metabolic affairs and signaling in the tumour microenvironment”

15h10 - 15h25: Break

15h25 - 16h10: Manuela Ferreira (CNC/CIBB, Portugal), “Immune cells at body barriers: From metabolic demands to systemic metabolism”

16h10: Students group work

March 11: The Revenge of Metabolism II: Outreach and Translation

Morning: Spinning-off metabolic research

9h30 - 10h45: Paulo Oliveira (MitoTAG, Portugal) “MitoTAG, from bench to start-up”

10h45 - 11h30: Fernanda Borges (University of Porto, Portugal) “Targeting mitochondria: Insights from medicinal chemistry towards drug development”

11h30 - 11h45: Break

11h45 - 12h30: John Jones (SEAentia, Portugal) “SEAentia: A metabolic approach to aquaculture”

Afternoon: Outreaching cell metabolism and disease
14h00 - 14h45: João Ramalho-Santos (CNC/CIBB, UC) “The role of  life scientists in Society: Why should we bother?”

14h45 - 15h30: Anabela Marisa Azul (CNC/CIBB, UC) “Time to bring mitochondria to ‘real-life’. Insights from interdisciplinary and participatory research to reach broader audiences”

15h30 - 15h45: Break

15h45 - 16h30: Maria Kristiansen (Univ Copenhagen, Denmark) “Interdisciplinarity and co-creation: ways of enhancing science communication and strengthening impact”

16h30: Students group work

March 12: The Revenge of Metabolism III: Outreach and Translation Strikes Again in an Aging World

Morning: Metabolism and aging

10h00 - 10h45: João Teodoro (CNC/CIBB, Portugal) “Targeting mitochondrial Ischemia/Reperfusion injury: lessons from the lab and the bedside”

10h45 - 11h30: Filomena Silva (CNC/CIBB, Portugal) “Disruption of cell metabolism in Amyotrophic Lateral Sclerosis”

11h30 - 11h45: Break

11h45 - 12h30:  José Teixeira (CNC/CIBB, Portugal) “Non-alcoholic fatty liver disease: from lifestyles to mitochondria and beyond”

Afternoon: Outreaching cell metabolism and disease II

14h00 - 14h45: Ruth Koops van t Jagt (Aletta Jacobs School of Public Health, Univ Groningen, The Netherlands) “ Show, do not just tell. Using stories in health communication for people with low health literacy”

15h00 - 15h45: Sara Araújo (CES/UC; FEUC) “Challenges and possibilities of interdisciplinary approaches and methodologies. Is it worthless to learn from social sciences?”
15h30: Students group work

March 13: Avenging Metabolism: Student presentations

9h30 - 12h00: Student Presentations

14h00 - 15h00: CNC Seminar: Paula Macedo (CEDOC/UNL/APDP/IBIMED, Portugal) “Mechanistic-based phenotyping of natural history of diabetes: beyond glycemia”


For the Course evaluation, we propose a very challenging task.
In groups of 4 students (defined by draft), you need to create a fictitious business idea focusing on any topic covered in this course (e.g. biomarker discovery, intervention, novel equipment for diagnosis, etc, all focusing on metabolism and disease) and defend your proposal in a 7-minute pitch to potential investors. Think Shark Tank but CNC-style and with sharper teeth.

The presentation can be supported by any visual means (e.g. Powerpoint slides, MVP, etc) and must contain the following elements:
a) Problem to be solved
b) Current ideas/competition and limitations
c)  Your idea
d) Why your idea is better it better than the competition
e) Team
f) Funding requested / Predicted sales
g) Milestones of your project / possible exit
h) Closing punch line.


Following your business proposal, you also need to include a 3 min Science Communication/Community Engagement Plan related to your project.

NO PowerPoint or projected information is acceptable, but you can use other materials, if you wish.

All group members must present and answer questions.

Some useful links:

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