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PDBEB Courses 2018/2019 - Advanced Therapies
 
April 22 - 26
Coordinator: Luís Almeida (luispa@cnc.uc.pt) & Lino Ferreira (lino@biocant.pt)
PhD in Experimental Biology and Biomedicine
CNC - Center for Neuroscience and Cell Biology, University of Coimbra


Advanced Therapies 2019
April 22-26, 2019


Coordinators:
Luís Pereira de Almeida (luispa@cnc.uc.pt)
Lino da Silva Ferreira (Lino@biocant.pt)

Lecturers:
Lino Ferreira
Ricardo Neves
Hugo Fernandes
Mário Grãos
Vítor Francisco
Sónia Pinho
Miguel Mano
Irina Moreira
Alexandra Carvalho
Isaura Simões
Akhilesh Rai
João Nuno Moreira
Nuno Fonseca
Ana Cardoso
Olga Borges
Luis Pereira de Almeida
Ana Teresa Simões
Ana Rita Álvaro
Catarina Miranda
Liliana Mendonça
Magda Santana
Patrícia Albuquerque
Rita Perfeito
Rui Nobre
Sara Lopes
Sónia Duarte



COURSE SYLLABUS

April 22nd Monday in Coimbra
9.30h-9:45h: Course Presentation
Luís Pereira de Almeida

9:45-10:15: Molecular therapy of brain disorders
Luís Pereira de Almeida

Break

10:30- 11:00: Transplantation of Neural Stem Cells as a therapeutic strategy
Liliana Mendonça

11:00- 11:30: Mesenchymal stem cells in brain disorders
Catarina Miranda

Break

11:45- 12:15: Induced pluripotent stem cells to model neurodegeneration
Ana Rita Álvaro

Lunch

14:00-14:30: Stem cells and exosomes: a bi-directional intercommunication
Rita Perfeito

14.30h-15:30h: Playing around with the tumour microenvironment
Nuno Fonseca and João Nuno Moreira

Break

16:00-16:30 Exosomes as biomarkers and gene carriers to the brain
Patrícia Albuquerque

16:30-17:00 Gene editing strategies in gene therapy
Sara Lopes


April 23rd Tuesday in Coimbra

9:00- 9:30h: Viral Vectors: from Production to Opportunities
Rui Nobre

9:30-10:00: MicroRNA-mediated gene silencing in neurodegenerative disease
Sónia Duarte

10:00-10.30h: LncRNAs as potential targets for cancer therapy
Ana Maria Cardoso


Break

11:15- 11:45h: Biomarkers
Magda Santana

11:45 – 12:15 Playing around with Vaccines
Olga Borges

Afternoon in Cantanhede


14:00h-15:00h: Regenerative Medicine: from the bench to the bedside + stem cells and drug screening
Hugo Fernandes

15:00h- 16:00h- Metabolic modulation can impact on stem cell physiology
Ricardo Neves

16:00h- 17:00h- Mechanobiology and neurodegenerative diseases
Mário Grãos

17:00h-18:00h- Biomaterials to modulate the activity of stem cells
Lino Ferreira



April 24th in Cantanhede

09:00h-10:00h: Ageing: models and therapies
Lino Ferreira

10:00h- 11:00h- Research highlights
Vitor Francisco + Sonia Pinho

11:00h-12:00h- Exploring high-throughput screening as a functional genomics tool in biomedicine
Miguel Mano

Lunch

14.00h-15.00h: Big pharma in the era of artificial intelligence
 Irina Moreira

15.00h-16:00h: Rational design of enzymes for advanced therapies
Alexandra Carvalho

16:00-17:00h- Rickettsial subversion tactics to evade host innate immunity
Isaura Simões

17:00-18:00h- Nanotechnology-based approaches to fight bacteria
Akhilesh Rai



April 26th in Coimbra

9:00 – 12:30 Assignments - Presentation of papers

14:00 Seminar: TBA


Background Reading:

Palsson, B.Ø. and Bhatia, S.N., Tissue Engineering, Pearson Prentice Hall Bioengineering, 2004;
Vunjak-Novakovic, G. and Freshney, R., Culture of Cells for Tissue Engineering, Wiley, 2006;

Atala, A., Lanza, R., et al, Principles of Regenerative Medicine, Academic Press, 2007;
Schaffer, D., Bronzino J.D., Peterson, D.R., Stem Cell Engineering, Principles and Practices, CRC Press, 2013;

Xu, J, Du, Y., Deng, H. Direct Lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell 2015, 16, 119

Joana Saraiva, Rui Nobre and Luis Pereira de Almeida. Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9. Journal of Controlled Release. 2016 Nov 10;241:94-109. doi: 10.1016/j.jconrel.2016.09.011. IF 7.786.

Rufino-Ramos D, Albuquerque PR, Carmona V, Perfeito R, Nobre RJ, Pereira de Almeida L.Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases. J Control Release. 2017 Sep 28;262:247-258. doi: 10.1016/j.jconrel.2017.07.001. Epub 2017 Jul 4. Review.

Mendonça LS, Onofre I, Miranda CO, Perfeito R, Nóbrega C, de Almeida LP. Stem Cell-Based Therapies for Polyglutamine Diseases. Adv Exp Med Biol. 2018;1049:439-466. doi: 10.1007/978-3-319-71779-1_21.

Matos CA, Carmona V, Vijayakumar UG, Lopes S, Albuquerque P, Conceição M, Nobre RJ, Nóbrega C, de Almeida LP. Gene Therapies for Polyglutamine Diseases. Adv Exp Med Biol. 2018;1049:395-438. doi: 10.1007/978-3-319-71779-1_20.

Nóbrega C, Simões AT, Duarte-Neves J, Duarte S, Vasconcelos-Ferreira A, Cunha-Santos J, Pereira D, Santana M, Cavadas C, de Almeida LP. Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis. Adv Exp Med Biol. 2018;1049:349-367. doi: 10.1007/978-3-319-71779-1_18.


Global Assessment of Stem Cell Engineering
(http://scec.gatech.edu/sites/default/files/StemCellEngineering-CompleteReport.pdf).

Regenerative Medicine 2006
(can be downloaded at http://stemcells.nih.gov/info/scireport/2006report.htm).

StemBook, http://www.stembook.org/, Harvard Stem Cell Institute
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