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PDBEB Courses 2018/2019 - Neurodegenerative disorders
 
April 8 - 12
Coordinators: Paula I Moreira, Cláudia Pereira, Armanda Santos, Teresa Cruz, Sandra M Cardoso

Registration Deadline: April 5, 2019 to srocha@cnc.uc.pt
PDBEB COURSE: “NEURODEGENERATIVE DISORDERS”

ORGANIZERS: Paula I. Moreira, Cláudia Pereira, Armanda Santos, Teresa Cruz e Sandra Morais Cardoso

CNC Auditorium April 8-12, 2019


Objectives: This advanced course is aimed to give a “bench to bedside” perspective of the most common neurodegenerative disorders, including Alzheimer disease, Parkinson disease, Huntington disease, Machado-Joseph disease, amyotrophic lateral sclerosis and multiple sclerosis, providing an overview of the current knowledge on these disorders. Different aspects of each disease will be discussed including clinical aspects, basic research (molecular and cellular biology) and translation of basic research into biomarkers for early and effective diagnosis and therapies.

PROGRAM
Monday (April 8)

9:30 – 10:15     Course presentation
Paula I. Moreira (FMUC & CNC)

10:30 – 11:15     Clinical aspects of multiple sclerosis (MS)
Filipe Palavra (CHUC - Centro Hospitalar e Universitário de Coimbra)

11:30 – 12:15     Remyelination strategies in multiple sclerosis
Sofia Viana (Instituto Politécnico de Coimbra & iCBR/FMUC)

        Lunch

14:30 – 15:15     Clinical aspects of amyotrophic lateral sclerosis (ALS)
Anabela Matos (CHUC - Centro Hospitalar e Universitário de Coimbra)

15:30 – 16:15     Cellular and molecular mechanisms in ALS
Dora Brites (FFUL)

16:30 – 17:15     Dendritic cell-based approaches for treatment of neurodegenerative disorders
Teresa Cruz (FFUC & CNC)

Tuesday (April 9)

9:30 – 10:15     Clinical aspects of polyglutamine (PoliQ) disorders
Cristina Januário (FMUC & CHUC - Centro Hospitalar e Universitário de Coimbra)

10:30 – 11:15     Molecular and cellular pathogenesis of Huntington disease (HD) – strategies for neuroprotective treatment
A. Cristina Rego (FMUC & CNC)

11:30 – 12:15     Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy
Clévio Nobrega (Centre for Biomedical Research, UAlg)

        Lunch

14:30 – 15:15     Machado-Joseph disease: from models to therapeutic approaches
Luis Pereira Almeida (FFUC & CNC)

15:30 – 16:15     Dementia: clinical aspects and clinical trials
Isabel Santana (FMUC & CHUC - Centro Hospitalar e Universitário de Coimbra)

16:30 – 17:15     Molecular and cellular biology of Alzheimer disease (AD)
Cláudia Pereira (FMUC & CNC)

Wednesday (April 10)

9:30 – 10:15     Metabolic disturbances in AD
Paula I Moreira (FMUC & CNC)

10:30 – 11:15     Hypoxia in AD - an old enemy?
Sónia Correia (CNC)

11:30 – 12:15     NLRP3 inflammasome activity in Alzheimer´s disease and related mouse models
Michael Heneka (University Hospital Bonn, Germany)

        Lunch

14:30 – 15:15     Role of astrocytes in synaptic dysfunction and memory loss: focus on AD
Paula Agostinho (FMUC & CNC)

15:30 – 16:30     SEMINAR: Neuroinflammation in Alzheimer´s disease
Michael Heneka (University Hospital Bonn, Germany)



Thursday (April 11)

9:30 – 10:15     New therapeutic strategies targeting β-secretase 1 (BACE1) for AD
    Armanda Santos (FFUC & CNC)

10:30 – 11:15     Clinical aspects of Parkinson Disease (PD)
António Freire (FMUC & CHUC - Centro Hospitalar e Universitário de Coimbra)

11:30 – 12:15     The etiology of PD
Pascal Derkinderen (Nantes University, France)

        Lunch

14:30 – 15:15     Parkinson´s disease and mitochondria
Jorge Oliveira (FFUP, Portugal)

15:30 – 16:15     Cell‐to‐cell spreading of α-synuclein in PD
Tiago F Outeiro (University Medical Center Goettingen, Germany)

16:30 – 17:15     Gut-Brain Axis in PD
Sandra Morais Cardoso (FMUC & CNC)

Friday (April 12)


9:30 - 10:15 SEMINAR: Is PD a Low-grade Inflammatory Bowel Disease?
Pascal Derkinderen (Nantes University, France)

10:30 – 11:15     Biofluid biomarkers in neurodegenerative dementias: current applications and future
perspectives
Inês Baldeiras (FMUC & CNC)

11:30 – 12:15     Deep brain stimulation: from PD to most recent indications and future developments
Rui Vaz (FMUP & Centro Hospitalar São João, Porto)

        Lunch

14:30 - 15:15 Neuroimaging
    Miguel Castelo Branco (FMUC & CIBIT)

15:30 – 16:15 SEMINAR: Targeting Proteases for the Treatment of Distinct Neuropathologies: Inhibiting a Protease (Calpain) vs. Enhancing a Protease (Cathepsins)
 Ben Bahr (William C. Friday Laboratory, University of North Carolina – Pembroke, USA)

16:30 – 17:15     Student´s Written Examination


Lecturers affiliations and contacts:

A. Cristina Rego (a.cristina.rego@gmail.com; acrego@cnc.cj.uc.pt)
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Anabela Matos
(anabelapmatos@gmail.com)
Center of University Hospital of Coimbra (CHUC)

António Freire (afreireg@hotmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC)

Armanda Santos (aesantos@ci.uc.pt) - Organizer
Center for Neuroscience and Cell Biology (CNC) & Faculty of Pharmacy (FFUC), University of Coimbra, Coimbra, Portugal

Ben Bahr (Bahr@uncp.edu)
William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina - Pembroke, Pembroke, North Carolina, USA

Cláudia Pereira (claudia.mf.pereira@gmail.com; cpereira@cnc.uc.pt) - Organizer
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Clévio Nóbrega (cdnobrega@ualg.pt)
Centre for Biomedical Research, University of Algarve (UAlg), Algarve, Portugal

Cristina Januário (cristinajanuario@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Dora Brites (dbrites@ff.ulisboa.pt)
Research Institute for Medicines (iMed.ULisboa) & Department of Biochemistry and Human Biology Faculty of Pharmacy (FFUL), Universidade de Lisboa, Portugal

Elisabete Ferreiro (beferreiro@gmail.com)
Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), Coimbra, Portugal

Filipe Palavra (filipepalavra@gmail.com)
Center of University Hospital of Coimbra (CHUC) & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Portugal

Inês Baldeiras
(ines.baldeiras@sapo.pt)
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Isabel Santana (isabeljsantana@gmail.com)
Neurology Service at Center of University Hospital of Coimbra (CHUC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Jorge Oliveira (jorgemao@ff.up.pt)
REQUIMTE/LAQV, Department of Drug Sciences, Pharmacology Lab, Faculty of Pharmacy, University of Porto

Luís Pereira de Almeida
(luispa@cnc.uc.pt; luispa@ci.uc.pt)
Center for Neuroscience and Cell Biology (CNC) & Faculty of Pharmacy (FFUC), University of Coimbra, Coimbra, Portugal

Michael Heneka (michael.Heneka@ukb.uni-bonn.de)
German Center for Neurodegenerative Disorder (DZNE), Bonn, Germany; Department of Neurodegeneration Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany

Miguel Castelo-Branco (mcbranco@fmed.uc.pt)
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Paula Agostinho (pmgagostinho@gmail.com)
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Pascal Derkinderen (pascal.derkinderen@chu-nantes.fr)
University of Nantes & CHU - Centre Hospitalier Universitaire de Nantes, France

Paula I Moreira (pismoreira@gmail.com) - Organizer
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Rui Vaz (ruimcvaz@gmail.com)
Neurosurgery Service of S. João Hospital & Faculty of Medicine (FMUP), University of Porto Porto, Portugal

Sandra Morais Cardoso
(cardoso.sandra.m@gmail.com) - Organizer
Center for Neuroscience and Cell Biology (CNC) & Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal

Sofia Viana (sofia_viana@estescoimbra.pt)
Instituto Politécnico de Coimbra & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Portugal

Sónia C. Correia (sonia.s.correia84@gmail.com)
Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal

Teresa Cruz (trosete@ff.uc.pt) - Organizer
Center for Neuroscience and Cell Biology (CNC) & Faculty of Pharmacy (FFUC), University of Coimbra, Coimbra, Portugal

Tiago F. Outeiro (tiago.outeiro@med.uni-goettingen.de)
University Medical Center Goettingen, Germany
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